The role of nucleosomes in lupus

Current Opinion in Rheumatology

Volumn 12, Issue 5, 2000, Pages 369-373

  Amoura, Zahir ^a   Koutouzov, Sophie ^b   Piette, Jean Charles ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; DNA ANTIBODY; HISTONE ANTIBODY; IMMUNOGLOBULIN G ANTIBODY;

ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; DISEASE MARKER; HUMAN; NUCLEOSOME; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIGEN-ANTIBODY COMPLEX; AUTOANTIBODIES; DNA; HUMANS; IMMUNE TOLERANCE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; NUCLEOSOMES; RATS;

EID: 0033844141     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-200009000-00003     Document Type: Review

References (43)

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3. Regulation of nuclear antigen expression on the cell surface of human monocytes
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5. Nucleosome-restricted antibodies are detected before anti-dsDNA and/or anti-histone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice and are present in kidney eluates
6. Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus
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8. Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production
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11. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus
12. Accelerated programmed cell death of MRL-lpr-lpr T lymphocytes
13. In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases
14. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus
15. High levels of circulating apoptotic peripheral blood mononuclear cells in systemic lupus erythematosus
16. Systemic exposure to irradiated apoptotic cells induces autoantibody production
17. Nucleosomes inhibit phagocytosis of apoptotic thymocytes by peritoneal macrophages from MRL+/+ lupusprone mice
18. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
19. Experimental expression in mice and spontaneous expression in human SLE of polyomavirus T-antigen: A molecular basis for induction of antibodies to DNA and eukaryotic transcription factors
20. T cell lines specific for polyomavirus T-antigen recognize T-antigen complexed with nucleosomes: A molecular basis for anti-DNA antibody production
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22. The central role of chromatin in autoimmune responses to histones and dsDNA in systemic lupus erythematosus
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24. Nucleosomes occurring in protein-free hybridoma cell-culture: Evidence for programmed cell death
25. Crossreactivity of human and murine anti-DNA antibodies with heparan sulfate: The major glycosaminoglycan in glomerar basement membrane
26. Crossreactivity of monoclonal anti-DNA antibodies with heparan sulfate is mediated via bound DNA/histone complexes
27. A monoclonal anti-double-stranded DNA autoantibody binds to a 94-kDa cell-surface protein on various cell types via nucleosomes or a DNA-histone complex
28. Antibodies to histones in systemic lupus erythematosus: Localization of prominent autoantigens on histones H1 and H2B
29. Antibodies from patients with drug-induced and idiopathic lupus erythematosus react with epitopes restricted to the amino and carboxyl termini of histone
30. Histone autoantigens in murine lupus: Definition of a major epitope within an accessible region of chromatin
31. A murine nephritogenic monoclonal anti-DNA autoantibody binds directly to mouse laminin, the major non-collagenous protein component of the glomerular basement membrane
32. Antigen-specificity of antibodies bound to glomeruli of mice with systemic lupus erythematosus-like syndromes
33. Different mechanisms by which anti-DNA MoAbs bind to human endothelial cells and glomerular mesangial cells
34. Anti-DNA antibodies can bind to the glomerulus via two distinct mechanisms
35. Anti-nucleosome anti-bodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vitro
36. Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo
37. Glomerular uptake of nucleosomes: Evidence for receptor-mediated mesangial cell binding
38. Nucleosomes and histones are present in glomerular deposits in human lupus nephritis
39. Presence of antinucleosome autoantibodies in a restricted set of connective tissue diseases. Antinucleosome antibodies of the lgG3 subclass are markers of renal pathogenicity in systemic lupus erythematosus
40. Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes
41. Genetic dissection of SLE pathogenesis: Adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow-derived B cells
42. Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: Tolerance spreading impairs pathogenic function of autoimmune T and B cells
43. Major peptide autoepitopes for nucleosome-specific T cells of human lupus