Structural elements controlling anti-DNA antibody affinity and their relationship to anti-phosphorylcholine activity

Journal of Immunology

Volumn 156, Issue 8, 1996, Pages 3065-3073

  Pewzner Jung, Yael ^a   Simon, Thomas ^b,c   Eilat, Dan ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b UNIVERSITY OF COLOGNE   (Germany)

^c ELIAS Entwicklungslabor   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; DNA; DNA BINDING PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; PHOSPHOLIPID ANTIBODY; PHOSPHORYLCHOLINE;

AMINO ACID SEQUENCE; ANIMAL; ANTIBODY AFFINITY; ARTICLE; BAGG ALBINO MOUSE; CHEMISTRY; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; NEW ZEALAND BLACK MOUSE; NUCLEOTIDE SEQUENCE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIBODY AFFINITY; BASE SEQUENCE; DNA; DNA-BINDING PROTEINS; GENETIC VECTORS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MICE; MICE, INBRED BALB C; MICE, INBRED NZB; MOLECULAR SEQUENCE DATA; PHOSPHORYLCHOLINE; TRANSFECTION;

EID: 0030584886     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Kocks, C , and K. Rajewsky 1989 Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways. Annu. Rev. Immunol 7:537.
2. Goodnow, C. C 1992. Transgenic mice and analysis of B-cell tolerance. Annu Rev. Immunol. 10:489.
3. Theofilopoulos, A. N., and F. J. Dixon 1985. Murine models of systemic lupus erythematosus. Adv Immunol. 37:269.
4. Tan, E M. 1982. Antibodies to nuclear antigens: their immunology and medicine Adv. Immunol. 33:167
5. Stollar, B D 1986. Antibodies to DNA. CRC Crit Rev. Immunol. 5. 1.
6. Marion, T. N., D. M. Tillman, N T Jou, and R. J. Hill 1992 Selection of immunoglobulin variable regions in autoimmunity to DNA Immunol. Rev 128. 123.
7. Radic, M. Z., and M. Weigert. 1994 Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu. Rev Immunol. 12:487.
8. Eilat, D., and W. F. Anderson. 1994. Structure-function correlates of autoantibodies to nucleic acids lessons from immunochemical, genetic and structural studies. Mol. Immunol. 31.1377.
9. Eilat, D., D. M. Webster, and A. R. Rees. 1988. V region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice J. Immunol 141.1745.
10. Shlomchik, M., M. A. Mascelli, H. Shan, M. Z. Radic, D. Pisctsky, A. Marshak-Rothstein, and M. Weigert 1990. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp. Med. 171:265.
11. 2 terminal amino acid sequences. J. Immunol. 133:489.
12. Perlmutter, R. M., S. T. Crews, R. Douglas, B. Sorensen, N. Johnson, N. Nivera. P. J. Gearhart, and L. Hood. 1984. The generation of diversity in phosphorylcholine-binding antibodies Adv. Immunol. 35:1
13. H11-encoded anti-DNA autoantibodies derived from autoimmune (NZBxNZW) F1 mice. J. Exp. Med. 173:731.
14. Clarke, S H., K. Huppi, D Ruezinsky, L. Staudt, W. Gerhard, and M. Weigert. 1985. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin J. Exp. Med. 161:687.
15. Berek, C., B. M. Griffiths, and C Milstein. 1985. Molecular events during maturation of the immune response to oxazolone Nature 316:412.
16. Clarke, S H., J. L. Claflin, and S. Rudikoff. 1982. Polymorphisms in immunoglobulin heavy chains suggesting gene conversion. Proc. Natl. Acad. Sci. USA 79:3280.
17. 1 mice. J Exp. Med. 176:761.
18. Kofler, R , S. Geley, H Kofler, and A Helmberg. 1992. Mouse variable-region gene families: complexity, polymorphism and use in non-autoimmune responses. Immunol. Rev. 128:5
19. Clarke, S. H., and S. Rudikoff 1984. Evidence for gene conversion among immunoglobulin heavy chain variable region genes. J. Exp. Med 159:773.
20. Diamond, B., and M. D. Scharff. 1984. Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibooy specificity. Proc. Natl. Acad. Sci. USA 81:5841.
21. Neuberger, M S. 1983 Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. EMBO J. 2:1373.
22. Kunkel, T. A , J. D. Roberts, and R. A Zakour 1987. Rapid and efficient site-directed mutagenesis without phenotypic selection. Methods Enzymol. 154:367.
23. Feeney, A. J., S. H. Clarke, and D. E. Mosier. 1988. Specific H chain junctional diversity may be required for non-T15 antibodies to bind phosphorylcholine. J. Immunol. 141:1267.
24. Coffino, P., and M. Scharff 1971. Rate of somatic mutation in immunoglobulin production by mouse myeloma cells. Proc. Natl Acad. Sci. USA 68.219.
25. Roes, J., and K. Rajewsky. 1991. Cell autonomous expression of IgD is not essential for the maturation of conventional B cells Int Immunol. 3:1367.
26. H families S107 or J606 bind to protein A. J Immunol. 145:2989.
27. Eilat, D. 1989. The measurement of anti-DNA activity in the sera of patients with systemic lupus erythematosus. theoretical and practical considerations. Autoimmunity 3:299
28. Schreibert, G., S. Metzger. E Aizenman, S. Roza, M. Cashel, and G. Glaser. 1991. Overexpression of the rel A gene in Escherichia colt. J. Biol. Chem. 266: 3760.
29. 1 mice Proc. Natl Acad. Sci. USA 85.3970.
30. H genes in CBA/J mice J. Exp. Med 168:1339.
31. K gene classification by nucleic acid sequence similarity. Immunogenetics 30:475.
32. Rudikoff, S. 1983. Immunoglobulin structure-function correlates: antigen binding and idiotypes. Contemp. Top. Mol. Immunol. 9:169.
33. Eilat, D., and R. Fischel. 1991. Recurrent utilization of genetic elements in V regions of antinucleic acid antibodies from autoimmune mice. J. Immunol. 147: 361.
34. Baccala, R., T. V. Quang, M. Gilblert, T Ternynck, and S. Avrameas. 1989. Two munne natural polyreactive autoantibodies are encoded by nonmutated germ-line genes. Proc. Natl. Acad. Sci USA 86:4624.
35. Ballard, D. W., S. P Lynn, S. F Gardner, and E. W. Voss, Jr. 1984. Specificity and kinetics defining the interaction between a murine monoclonal autoantibody and DNA. J. Biol. Chem. 259:3492.
36. Aarden, L. A., F. Lakmaker, and E R. de Groot. 1976. Immunology of DNA IV Quantitative aspects of the Farr assay. J. Immunol. Methods 11:153.
37. Sharon, J. 1990. Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold. Proc. Natl. Acad. Sci. USA 87:4814.
38. Dighiero, G., P Lymben, J. C. Mazié, S. Rouyre, G S Butler-Browne, R. G. Whalen, and S. Avrameas. 1983 Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens. J. Immunol. 131:2267.
39. Friguet, B., A. F Chaffotte, L. Djavadi-Ohaniance, and M. E. Goldberg. 1985. Measurement of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay. J. Immunol. Methods 77:305
40. Malmqvist, M. 1993. Surface plasmon resonance for detection and measurement of antibody-antigen affinity and kinetics Curr Opin. Immunol. 5:282
41. Radic, M Z., J. Mackle, J. Erikson, C. Mol. W. F. Anderson, and M. Weigert. 1993. Residues that mediate DNA binding of autoimmune antibodies. J. Immunol. 150.4966.
42. Kocks, C , and K Rajewsky. 1988 Stepwise iutraclonal maturation of antibody affinity through somatic mutation. Proc. Natl. Acad. Sci. USA 85:8206.
43. Berek, C., and C. Milstein 1987. Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev. 96.23.
44. Jacobson, B. A., J. Sharon, H. Shan, M. Shlomchik, M. G. Weigert, and A. Marshak-Rothstein. 1994. An isotype switched and somatically mutated rheumatoid factor clone isolated from a MRL-Ipr//pr mouse exhibits limited intraclonal affinity maturation. J. Immunol. 152:4489.
45. Berek, C. 1992. The development of B cells and the B-cell repertoire in the microenvironment of the germinal center Immunol. Rev. 126:5.
46. Chen, C., Z. Nagy, M Z. Radic, R. R. Hardy, D. Huszar, S. A Camper, and M. Weigert. 1995. The site and stage of anti-DNA B cell deletion Nature 373: 252.
47. Roark, J. H., C. L. Kuntz, K. A. Nguyen, A J. Caton, and J. Erikson. 1995. Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus. J Exp. Med 181:1157.
48. Seeman, N. C , J. M Rosenberg, and A. Rich. 1976. Sequence-specific recognition of double helical nucleic acids by protein. Proc Natl. Acad Sci. USA 73:804.
49. Ibrahim, S. M., M. Weigert, C. Basu, J. Erikson, and M. Z. Radic. 1995. Light chain contribution to specificity in anti-DNA antibodies. J. Immunol. 155:3223.
50. Radie, M. Z., M. A. Mascelli, J. Erikson, H. Shan, and M. Weigert. 1991. Ig H and L chain contributions to autoimmune specificities J. Immunol. 146.176.
51. Behar, S. M , N. C. Chien, S. Corbet, B. Diamond, E. D. Getzoff, D. Lustgarten, V. A. Roberts, M. D. Scharff, and S. U. Shin. 1989. Impact of somatic mutation of the S107 (T15) heavy chain V region reactive with self and nonself. Cold Spring Harb. Symp. Quant. Biol 54:921.
52. Limparrasithikul, W., R. Subhransu, and B. Diamond 1995. Cross-reactive antibodies have both protective and pathogenic potential. J. Immunol. 155:967.