Mixed antibody and T cell responses to peanut and the peanut allergens Ara h 1, Ara h 2, Ara h 3 and Ara h 6 in an oral sensitization model

Clinical and Experimental Allergy

Volumn 34, Issue 9, 2004, Pages 1422-1428

  Van Wijk, F ^a,b,c   Hartgring, S ^a   Koppelman, S J ^b   Pieters, R ^a   Knippels, L M J ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Cytokines; Oral mouse model; Peanut allergens; Peanut hyper sensitivity; Sensitization; Th1 Th2 responses

Indexed keywords

ANTIBODY; CHOLERA TOXIN; CYTOKINE; FOOD ALLERGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; PROTEIN ARA H 1; PROTEIN ARA H 2; PROTEIN ARA H 3; PROTEIN ARA H 6; UNCLASSIFIED DRUG;

ANAPHYLAXIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; EXPOSURE; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; MOUSE; NONHUMAN; PEANUT; PEANUT ALLERGY; PRIORITY JOURNAL; SENSITIZATION; SERUM; SPLEEN; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ADMINISTRATION, ORAL; ALLERGENS; ANIMALS; ARACHIS HYPOGAEA; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GLYCOPROTEINS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULINS; MICE; MICE, INBRED C3H; PEANUT HYPERSENSITIVITY; PLANT PROTEINS; SPLEEN; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TH2 CELLS;

EID: 4544328117     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2004.02062.x     Document Type: Article

References (56)

1. Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001; 107:191-3.
2. Sicherer SH, Munoz-Furlong A, Burks AW, Sampson HA. Prevalence of peanut and tree nut allergy in the US determined by a random digit dial telephone survey. J Allergy Clin Immunol 1999; 103:559-62.
3. Grundy J, Matthews S, Bateman B, Dean T, Arshad SH. Rising prevalence of allergy to peanut in children: data from 2 sequential cohorts. J Allergy Clin Immunol 2002; 110:784-9.
4. Hourihane JO, Roberts SA, Warner JO. Resolution of peanut allergy: case-control study. BMJ 1998; 316:1271-5.
5. Skolnick HS, Conover-Walker MK, Koerner CB, Sampson HA, Burks W, Wood RA. The natural history of peanut allergy. J Allergy Clin Immunol 2001; 107:367-74.
6. Host A, Halken S, Jacobsen HP, Christensen AE, Herskind AM, Plesner K. Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood. Pediatr Allergy Immunol 2002; 13 (Suppl. 15):23-8.
7. Sampson HA, McCaskill CC. Food hypersensitivity and atopic dermatitis: evaluation of 113 patients. J Pediatr 1985; 107:669-75.
8. Dannaeus A, Inganas M. A follow-up study of children with food allergy. Clinical course in relation to serum IgE- and IgG-antibody levels to milk, egg and fish. Clin Allergy 1981; 11:533-9.
9. Fries JH. Peanuts: allergic and other untoward reactions. Ann Allergy 1982; 48:220-6.
10. Burks AW, Williams LW, Helm RM, Connaughton C, Cockrell G, O'Brien T. Identification of a major peanut allergen, Ara h I, in patients with atopic dermatitis and positive peanut challenges. J Allergy Clin Immunol 1991; 88:172-9.
11. Burks AW, Williams LW, Connaughton C, Cockrell G, O'Brien TJ, Helm RM. Identification and characterization of a second major peanut allergen, Ara h II, with use of the sera of patients with atopic dermatitis and positive peanut challenge. J Allergy Clin Immunol 1992; 90:962-9.
12. Burks W, Sampson HA, Bannon GA. Peanut allergens. Allergy 1998; 53:725-30.
13. Rabjohn P, Helm EM, Stanley JS et al. Molecular cloning and epitope analysis of the peanut allergen Ara h 3. J Clin Invest 1999; 103:535-42.
14. Burks AW, Shin D, Cockrell G, Stanley JS, Helm RM, Bannon GA. Mapping and mutational analysis of the IgE-binding epitopes on Ara h 1, a legume vicilin protein and a major allergen in peanut hypersensitivity. Eur J Biochem 1997; 245:334-9.
15. Shin DS, Compadre CM, Maleki SJ et al. Biochemical and structural analysis of the IgE binding sites on Ara h1, an abundant and highly allergenic peanut protein. J Biol Chem 1998; 273:13753-9.
16. Stanley JS, King N, Burks AW et al. Identification and mutational analysis of the immunodominant IgE binding epitopes of the major peanut allergen Ara h 2. Arch Biochem Biophys 1997; 342:244-53.
17. Viquez OM, Summer CG, Dodo HW. Isolation and molecular characterization of the first genomic clone of a major peanut allergen, Ara h 2. J Allergy Clin Immunol 2001; 107:713-7.
18. Clarke MC, Kilburn SA, Hourihane JO, Dean KR, Warner JO, Dean TP. Serological characteristics of peanut allergy. Clin Exp Allergy 1998; 28:1251-7.
19. Kleber-Janke T, Crameri R, Appenzeller U, Schlaak M, Becker WM. Selective cloning of peanut allergens, including profilin and 2S albumins, by phage display technology. Int Arch Allergy Immunol 1999; 119:265-74.
20. Knippels LM, Penninks AH, Spanhaak S, Houben GF. Oral sensitization to food proteins: a Brown Norway rat model. Clin Exp Allergy 1998; 28:368-75.
21. Li XM, Schofield BH, Huang CK, Kleiner GI, Sampson HA. A murine model of IgE-mediated cow's milk hypersensitivity. J Allergy and Clin Immunology 1999; 103:206-14.
22. Li XM, Serebrisky D, Lee SY et al. A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses. J Allergy Clin Immunol 2000; 106:150-8.
23. Boushey HA, Fahy JV. Targeting cytokines in asthma therapy: round one. Lancet 2000; 356:2114-6.
24. Kolopp-Sarda MN, Moneret-Vautrin DA, Gobert B et al. Polyisotypic antipeanut-specific humoral responses in peanut-allergic individuals. Clin Exp Allergy 2001; 31:47-53.
25. Lee SY, Huang CK, Zhang TF et al. Oral administration of IL-12 suppresses anaphylactic reactions in a murine model of peanut hypersensitivity. Clin Immunol 2001; 101:220-8.
26. Koppelman SJ, Knol EF, Vlooswijk RA et al. Peanut allergen Ara h 3: isolation from peanuts and biochemical characterization. Allergy 2003; 58:1144-51.
27. Koppelman SJ, Vlooswijk RA, Knippels LM et al. Quantification of major peanut allergens Ara h 1 and Ara h 2 in the peanut varieties Runner, Spanish, Virginia, and Valencia, bred in different parts of the world. Allergy 2001; 56:132-7.
28. Stevens TL, Bossie A, Sanders VM et al. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 1988; 334:255-8.
29. Maggi E. The TH1/TH2 paradigm in allergy. Immunotechnology 1998; 3:233-44.
30. Suomalainen H, Soppi E, Laine S, Isolauri E. Immunologic disturbances in cow's milk allergy, 2: evidence for defective interferon-gamma generation. Pediatr Allergy Immunol 1993; 4:203-7.
31. Andre F, Pene J, Andre C. Interleukin-4 and interferon-gamma production by peripheral blood mononuclear cells from food-allergic patients. Allergy 1996; 51:350-5.
32. Salvi SS, Babu KS, Holgate ST. Is asthma really due to a polarized T cell response toward a helper T cell type 2 phenotype? Am J Respir Crit Care Med 2001; 164:1343-6.
33. Holen E, Bolann B, Elsayed S. Novel B and T cell epitopes of chicken ovomucoid (Gal d 1) induce T cell secretion of IL-6, IL-13, and IFN-gamma. Clin Exp Allergy 2001; 31:952-64.
34. Smart JM, Kemp AS. Increased Th1 and Th2 allergen-induced cytokine responses in children with atopic disease. Clin Exp Allergy 2002; 32:796-802.
35. Ng TW, Holt PG, Prescott SL. Cellular immune responses to ovalbumin and house dust mite in egg-allergic children. Allergy 2002; 57:207-14.
36. Eigenmann PA, Frossard CP. The T lymphocyte in food-allergy disorders. Curr Opin Allergy Clin Immunol 2003; 3:199-203.
37. Morafo V, Srivastava K, Huang CK et al. Genetic susceptibility to food allergy is linked to differential TH2-TH1 responses in C3H/HeJ and BALB/c mice. J Allergy Clin Immunol 2003; 111:1122-8.
38. Turcanu V, Maleki SJ, Lack G. Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J Clin Invest 2003; 111:1065-72.
39. Zhang ZY, Michael JG. Orally inducible immune unresponsiveness is abrogated by IFN-gamma treatment. J Immunol 1990; 144:4163-5.
40. Adams RB, Planchon SM, Roche JK. IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine binding. J Immunol 1993; 150:2356-63.
41. Yssel H, De Waal Malefyt R, Roncarolo MG et al. IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells. J Immunol 1992; 149:2378-84.
42. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19:683-765.
43. Oh JW, Seroogy CM, Meyer EH et al. CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol 2002; 110:460-8.
44. Hauer AC, Breese EJ, Walker-Smith JA, MacDonald TT. The frequency of cells secreting interferon-gamma and interleukin-4, -5, and -10 in the blood and duodenal mucosa of children with cow's milk hypersensitivity. Pediatr Res 1997; 42:629-38.
45. Maciorkowska E, Dzieciol J, Kemona A, Kaczmarski M. Evaluation of selected cytokines and mononuclear cell infiltration in gastric mucosa of children with food allergy. Med Sci Monit 2000; 6:567-72.
46. Mocellin S, Panelli MC, Wang E, Nagorsen D, Marincola FM. The dual role of IL-10. Trends Immunol 2003; 24:36-43.
47. Lycke N. The mechanism of cholera toxin adjuvanticity. Res Immunol 1997; 148:504-20.
48. Marinaro M, Staats HF, Hiroi T et al. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol 1995; 155:4621-9.
49. Xu-Amano J, Kiyono H, Jackson RJ et al. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med 1993; 178:1309-20.
50. Hornquist E, Lycke N. Cholera toxin adjuvant greatly promotes antigen priming of T cells. Eur J Immunol 1993; 23:2136-43.
51. Hornquist E, Grdic D, Mak T, Lycke N. CD8-deficient mice exhibit augmented mucosal immune responses and intact adjuvant effects to cholera toxin. Immunology 1996; 87:220-9.
52. Kim PH, Eckmann L, Lee WJ, Han W, Kagnoff MF. Cholera toxin and cholera toxin B subunit induce IgA switching through the action of TGF-beta 1. J Immunol 1998; 160:1198-203.
53. Fayette K, Weiss NS. Salivary IgA levels in atopic children. Ann Allergy 1977; 39:328-31.
54. van Asperen PP, Gleeson M, Kemp AS et al. The relationship between atopy and salivary IgA deficiency in infancy. Clin Exp Immunol 1985; 62:753-7.
55. Bottcher MF, Haggstrom P, Bjorksten B, Jenmalm MC. Total and allergen-specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age. Clin Exp Allergy 2002; 32:1293-8.
56. de Jong EC, Van Zijverden M, Spanhaak S, Koppelman SJ, Pellegrom H, Penninks AH. Identification and partial characterization of multiple major allergens in peanut proteins. Clin Exp Allergy 1998; 28:743-51.