Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation

Cellular Microbiology

Volumn 6, Issue 10, 2004, Pages 927-938

  Robinson, Karen ^a,b   Taraktsoglou, Maria ^a   Rowe, Kherie S J ^a   Wooldridge, Karl G ^a   Ala'Aldeen, Dlawer A A ^a  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CYCLOOXYGENASE 2; ENDOTOXIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; LIPOOLIGOSACCHARIDE; OUTER MEMBRANE PROTEIN; VIRULENCE FACTOR;

APOPTOSIS; ARTICLE; BACTERIAL STRAIN; CELL VIABILITY; DNA MICROARRAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INFLAMMATION; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA TRANSLATION; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; BACTERIAL PROTEINS; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 2; CYTOKINES; ENZYME INHIBITORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMUNE SYSTEM; ISOENZYMES; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MENINGES; MENINGITIS, MENINGOCOCCAL; NEISSERIA MENINGITIDIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; STAUROSPORINE;

BACTERIA (MICROORGANISMS); NEISSERIA; NEISSERIA MENINGITIDIS;

EID: 4544315971     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2004.00410.x     Document Type: Article

References (50)

1. Abdel Hadi, H., Wooldridge, K.G., Robinson, K., and Ala'Aldeen, D.A.A. (2001) Identification and characterization of App: an immunogenic autotransporter protein of Neisseria meningitidis. Mol Microbiol 41: 611-624.
2. + T-cell and B-cell stimulating antigen detected by expression cloning. Mol Microbiol 37: 1094-1105.
3. Beck, S.C., and Meyer, T.F. (2000) IgA1 protease from Neisseria gonorrhoeae inhibits TNFalpha-mediated apoptosis of human monocytic cells. FEBS Lett 472: 287-292.
4. Bingen, E., Lambert-Zechovsky, N., Mariani-Kurkdjian, P., Doit, C., Aujard, Y., Fournerie, F., and Mathieu, H. (1990) Bacterial counts in cerebrospinal fluid of children with meningitis. Eur J Clin Microbiol Infect Dis 9: 278-281.
5. Binnicker, M.J., Williams, R.D., and Apicella, M.A. (2003) Infection of human urethral epithelium with Neisseria gonorrhoeae elicits an upregulation of host anti-apoptotic factors and protects cells from staurosporine-induced apoptosis. Cell Microbiol 5: 549-560.
6. Cao, C., Matsumura, K., Shirakawa, N., Maeda, M., Jikihara, I., Kobayashi, S., and Watanabe, Y. (2001) Pyrogenic cytokines injected into the rat cerebral ventricle induce cyclooxygenase-2 in brain endothelial cells and also upregulate their receptors. Eur J Neurosci 13: 1781-1790.
7. Chandra, D., Liu, J.W., and Tang, D.G. (2002) Early mitochondrial activation and cytochrome c upregulation during apoptosis. J Biol Chem 277: 50842-50854.
8. Christodoulides, M., Makepeace, B.L., Partridge, K.A., Kaur, D., Fowler, M.I., Weller, R.O., and Heckels, J.E. (2002) Interaction of Neisseria meningitidis with human meningeal cells induces the secretion of a distinct group of chemotactic, proinflammatory, and growth-factor cytokines. Infect Immun 70: 4035-4044.
9. Constantin, D., Ala Aldeen, D., and Murphy, S. (2002) Transcriptional activation of nitric oxide synthase-2, and NO-induced cell death, in mouse cerebrovascular endothelium exposed to Neisseria meningitidis. J Neurochem 81: 270-276.
10. Cory, S., and Adams, J.M. (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2: 647-656.
11. Dieter, P., Scheibe, R., Kamionka, S., and Kolada, A. (2002) LPS-induced synthesis and release of PGE2 in liver macrophages: regulation by CPLA2, COX-1, COX-2, and PGE2 synthase. Adv Exp Med Biol 507: 457-462.
12. Dixon, G.L., Heyderman, R.S., Kotovicz, K., Jack, D.L., Andersen, S.R., Vogel, U., et al. (1999) Endothelial adhesion molecule expression and its inhibition by recombinant bactericidal/permeability-increasing protein are influenced by the capsulation and lipooligosaccharide structure of Neisseria meningitidis. Infect Immun 67: 5626-5633.
13. Dixon, G.L.J., Newton, P.J., Chain, B.M., Katz, D., Andersen, S.R., Wong, S., et al. (2001) Dendritic cell activation and cytokine production induced by group B Neisseria meningitidis: interleukin-12 production depends on lipopolysaccharide expression in intact bacteria. Infect Immun 69: 4351-4357.
14. Duan, H., Wang, Y., Aviram, M., Swaroop, M., Loo, J.A., Bian, J., et al. (1999) SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Mol Cell Biol 19: 3145-3155.
15. Ejima, K., Layne, M.D., Carvajal, I.M., Kritek, P.A., Baron, R.M., Chen, Y.H., et al. (2003) Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death. FASEB J 17: 1325-1327.
16. El-Sherif, A.M., Seth, R., Tighe, P.J., and Jenkins, D. (2000) Decreased synthesis and expression of TGF-beta1, beta2, and beta3 in epithelium of HPV 16-positive cervical pre-cancer: a study by microdissection, quantitative RT-PCR, and immunocytochemistry. J Pathol 192: 494-501.
17. Gilroy, D.W., Colville-Nash, P.R., Willis, D., Chivers, J., Paul-Clark, M.J., and Willoughby, D.A. (1999) Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med 5: 698-701.
18. Graham, S.H., and Hickey, R.W. (2003) Cyclooxygenases in central nervous system diseases: a special role for cyclooxygenase 2 in neuronal cell death. Arch Neurol 60: 628-630.
19. Hardy, S.J., Christodoulides, M., Weller, R.O., and Heckels, J. E. (2000) Interactions of Neisseria meningitidis with cells of the human meninges. Mol Microbiol 36: 817-829.
20. Haskill, S., Peace, A., Morris, J., Sporn, S.A., Anisowicz, A., Lee, S.W., et al. (1990) Identification of three related human GRO genes encoding cytokine functions. Proc Natl Acad Sci USA 87: 7732-7736.
21. Hinz, B., and Brune, K. (2002) Cyclooxygenase-2-10 years later. J Pharmacol Exp Ther 300: 367-375.
22. Hitoshi, Y., Lorens, J., Kitada, S.I., Fisher, J., LaBarge, M., Ring, H.Z., et al. (1998) Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity 8: 461-471.
23. Hotchkiss, R.S., Chang, K.C., Swanson, P.E., Tinsley, K.W., Hui, J.J., Klender, P., et al. (2000) Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nature Immunol 1: 496-501.
24. Hsu, D.K., Yang, R.Y., and Pan, Z., YuL., Salomon, D.R., Fung-Leung, W.P., and Liu, F.T. (2000) Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses. Am J Pathol 156: 1073-1083.
25. Jarvis, G.A., Li, J., and Swanson, K.V. (1999) Invasion of human mucosal epithelial cells by Neisseria gonorrhoeae upregulates expression of intercellular adhesion molecule 1 (ICAM-1). Infect Immun 67: 1149-1156.
26. Leu, C.M., Wong, F.H., Chang, C., Huang, S.F., and Hu, C.P. (2003) Interleukin-6 acts as an antiapoptotic factor in human esophageal carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways. Oncogene 22: 7809-7818.
27. Lin, M.T., Lee, R.C., Yang, P.C., Ho, F.M., and Kuo, M.L. (2001) Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1.0 cells. Involvement of phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 276: 48997-49002.
28. Lomholt, H., Poulsen, K., and Kilian, M. (1995) Comparative characterization of the iga gene encoding IgA1 protease in Neisseria meningitidis, Neisseria gonorrhoeae and Haemophilus influenzae. Mol Microbiol 15: 495.
29. Lorenzen, D.R., Dux, F., Wolk, U., Tsirpouchtsidis, A., Haas, G., and Meyer, T.F. (1999) Immunoglobulin A1 protease, en exoenzyme of pathogenic Neisseriae, is a potent inducer of proinflammatory cytokines. J Exp Med 190: 1049-1058.
30. Massari, P., Ho, Y., and Wetzler, L.M. (2000) Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis. Proc Natl Acad Sci USA 97: 9070-9075.
31. Massari, P., King, C.A., Ho, A.Y., and Wetzler, L.M. (2003) Neisserial PorB is translocated to the mitochondria of HeLa cells infected with Neisseria meningitidis and protects cells from apoptosis. Cell Microbiol 5: 99-110.
32. Melkonyan, H.S., Chang, W.C., Shapiro, J.P., Mahadevappa, M., Fitzpatrick, P.A., Kiefer, M.C., et al. (1997) SARPs: a family of secreted apoptosis-related proteins. Proc Natl Acad Sci USA 94: 13636-13641.
33. Miller, M.D., and Krangel, M.S. (1992) The human cytokine I-309 is a monocyte chemoattractant. Proc Natl Acad Sci USA 89: 2950-2954.
34. Oberholzer, C., Oberholzer, A., Clare-Salzler, M., and Moldawer, L.L. (2001) Apoptosis in sepsis: a new target for therapeutic exploration. FASEB J 15: 879-892.
35. Opferman, J.T., Letai, A., Beard, C., Sorcinelli, M.D., Ong, C.C., and Korsmeyer, S.J. (2003) Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 426: 671-676.
36. Pfaffl, M.W. (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29: e45.
37. Puthier, D., Bataille, R., and Amiot, M. (1999) IL-6 upregulates mcl-1 in human myeloma cells through JAK / STAT rather than ras / MAP kinase pathway. Eur J Immunol 29: 3945-3950.
38. Robinson, K., Neal, K.R., Howard, C., Stockton, J., Atkinson, K., Scarth, E., et al. (2002) Characterization of humoral and cellular immune responses elicited by meningococcal carriage. Infect Immun 70: 1301-1309.
39. Salvesen, G.S., and Duckett, C.S. (2002) IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 3: 401-410.
40. Sprong, T., Stikkelbroeck, N., van der Ley, P., Steeghs, L., van Alphen, L., Klein, N., et al. (2001) Contributions of Neisseria meningitidis LPS and non-LPS to proinflammatory cytokine response. J Leukoc Biol 70: 283-288.
41. Steeghs, L., den Hartog, R., den Boer, A., Zomer, B., Roholl, P., and van der Ley, P. (1998) Meningitis bacterium is viable without endotoxin. Nature 392: 449-450.
42. Steeghs, L., de Cock, H., Evers, E., Zomer, B., Tommassen, J., and van der Ley, P. (2001) Outer membrane composition of a lipopolysaccharide-deficient Neisseria meningitidis mutant. EMBO J 20: 6937-6945.
43. Subbarayan, V., Sabichi, A.L., Llansa, N., Lippman, S.M., and Menter, D.G. (2001) Differential expression of cyclooxygenase-2 and its regulation by tumor necrosis factor-alpha in normal and malignant prostate cells. Cancer Res 61: 2720-2726.
44. Taha, M.K. (2000) Neisseria meningitidis induces expression of the TNF-alpha gene in endothelial cells. Cytokine 12: 21-25.
45. Thome, M., and Tschopp, J. (2001) Regulation of lymphocyte proliferation and death by FLIP. Nat Rev Immunol 1: 50-58.
46. Turner, D.P.J., Wooldridge, K.G., and Ala Aldeen, D.A.A. (2002) Autotransported serine protease A of Neisseria meningitidis: an immunogenic, surface-exposed outer membrane, and secreted protein. Infect Immun 70: 4447-4461.
47. Van Snick, J., Houssiau, F., Proost, P., Van Damme, J., and Renauld, J.C. (1996) I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis. J Immunol 157: 2570-2576.
48. Wells, D.B., Tighe, P.J., Wooldridge, K.G., Robinson, K., and Ala Aldeen, D.A.A. (2001) Differential gene expression during meningeal-meningococcal interaction: evidence for self-defense and early release of cytokines and chemokines. Infect Immun 69: 2718-2722.
49. Westerndorp, R.G.J., Langermans, J.A.M., Huizinga, T.W.J., Elouali, A.H., Verweij, C.L., Boomsma, D.I., and Vandenbrouke, J.P. (1997) Genetic influence on cytokine production and fatal meningococcal disease. Lancet 349: 170-173.
50. Yang, T., Sun, D., Huang, Y.G., Smart, A., Briggs, J.P., and Schnermann, J.B. (1999) Differential regulation of COX-2 expression in the kidney by lipopolysaccharide: role of CD14. Am J Physiol 277: F10-F16.