Transcriptional activation of nitric oxide synthase-2, and NO-induced cell death, in mouse cerebrovascular endothelium exposed to Neisseria meningitidis

Journal of Neurochemistry

Volumn 81, Issue 2, 2002, Pages 270-276

  Constantin, Despina ^a   Ala'Aldeen, Dlawer ^a   Murphy, Sean ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Blood brain barrier; Cytotoxicity; Endothelial cell; Meningitis; Nitric oxide; NOS 2

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; CELL DEATH; CENTRAL NERVOUS SYSTEM; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; INCUBATION TIME; MENINGITIS; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION;

ANIMALS; CELL DEATH; CELL LINE; CELL SURVIVAL; CEREBROVASCULAR CIRCULATION; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; LIPOPOLYSACCHARIDES; MICE; NEISSERIA MENINGITIDIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; POLY(ADP-RIBOSE) POLYMERASES; RNA, MESSENGER; SPECIES SPECIFICITY; SUBCELLULAR FRACTIONS;

ANIMALIA; NEISSERIA; NEISSERIA MENINGITIDIS;

EID: 0036312701     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00816.x     Document Type: Article

References (45)

1. A low virulent strain of Candida albicans enhances brain anticryptococcal defenses
2. Neurological sequelae and fatality as prognostic measures in 875 cases of bacterial meningitis
3. Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis
4. Expression of inducible nitric oxide synthase in cerebral endothelial cells is regulated by cytokine-activated astrocytes
5. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
6. Nitric oxide (NO): An effector of apoptosis
7. Potential role of nitric oxide in the pathophysiology of experimental bacterial meningitis in rats
8. Exacerbation of lymphocytic choriomeningitis in mice treated with the inducible nitric oxide synthase inhibitor aminoguanidine
9. Endogenous IL-10 is required for the prevention of hyperinflammatory intracerebral immune response in L. monocytogenes meningoencepahalitis
10. Expression of inducible nitric oxide synthase in bovine corneal endothelial cells and keratocytes in vitro after lipopolysaccharide and cytokines stimulation
11. Nitric oxide: An endothelial cell survival factor
12. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1b-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases
13. Acute bacterial meningitis in adults: A review of 493 episodes
14. Regulation of the cerebral circulation: Role of endothelium and potassium channels
15. Endothelial barrier dysfunction and p42 oxidation induced by TNF-alpha are mediated by nitric oxide
16. Cerebral endothelial cells release TNF- after stimulation with cell walls of Streptococcus pneumoniae and regulate inducible nitric oxide synthase and ICAM-1 expression via autocrine loops
17. Nitric oxide synthase type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection
18. Sound barrier. NO and blood-brain barrier permeability
19. 2 formation parallels blood-brain barrier disruption in an experimental rat model of bacterial meningitis
20. Reactive nitrogen species contribute to blood-labyrinth barrier disruption in supparative labyrinthitis complicating experimental pneumococcal meningitis in the rat
21. IL-4 induces apoptosis of endothelial cells through the caspase-3 -dependent pathway
22. NO: An inhibitor of cell death
23. Transcriptional activation following cerebral ischemia in mice of a promoter-deleted nitric oxide synthase-2 gene
24. Requirement of nitric oxide and calcium mobilization for the induction of apoptosis in adrenal vascular endothelial cells
25. Nitric oxide donor-induced increase in permeability of the blood-brain barrier
26. Oxyhemoglobin induces caspase-mediated cell death in cerebral endothelial cells
27. Eicosanoid metabolism in cerebromicrovascular endothelium
28. Nitric oxide donors induce apoptosis in glomerular mesangial cells, epithelial cells and endothelial cells
29. Nitric oxide and cell death
30. Inducible nitric oxide synthase: What difference does it make?
31. Poly (ADP-ribose) polymerase, nitric oxide and cell death
32. Nitric oxide is protective in listeric meningoencephalitis of rats
33. Inflammation is a component of neurodegeneration in response to Venezuelan equine encephalitis virus infection in mice
34. Activated astrocytes induce nitric oxide synthase-2 in cerebral endothelium via TNF-alpha
35. Perspective: Targeting nitric oxide in the adjuvant therapy of sepsis and meningitis
36. Contributions of Neisseria meningitidis LPS and non-LPS to proinflammatory cytokine response
37. Isolation and characterization of the Neisseria meningitidis lpxD-fabZ-lpxA gene cluster involved in lipid A biosynthesis
38. DNA damage induced by peroxynitrite: Subsequent biological effects
39. Topology of outer membrane porins in pathogenic Neisseria spp
40. The induction of apoptosis by bacterial pathogens
41. Differential gene expression during meningeal-meningococcal interaction
42. Differential expression of nitric oxide synthases in bacterial meningitis: Role of the inducible isoform for blood-brain barrier breakdown
43. Inducible nitric oxide synthase gene expression in the brain during systemic inflammation
44. Oxygen-glucose deprivation induces inducible nitric oxide synthase and nitrotyrosine expression in cerebral endothelial cells
45. Chemical hypoxia-ischemia induced apoptosis in cerebromicrovascular endothelial cells