Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas

Cancer Letters

Volumn 209, Issue 1, 2004, Pages 1-6

  Nikiforova, Marina N ^a   Ciampi, Raffaele ^a   Salvatore, Giuliana ^b   Santoro, Massimo ^b   Gandhi, Manoj ^a   Knauf, Jeffrey A ^c   Thomas, Gerry A ^d   Jeremiah, Stephen ^d   Bogdanova, Tatyana I ^e   Tronko, Mykola D ^e   Fagin, James A ^c   Nikiforov, Yuri E ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF CINCINNATI   (United States)

^d SINGLETON HOSPITAL   (United Kingdom)

^e STATE INSTITUTION NATIONAL RESEARCH CENTER FOR RADIATION MEDICINE OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE   (Ukraine)

Author keywords

BRAF mutation; Radiation exposure; RET PTC Rearrangement; Thyroid cancer

Indexed keywords

B RAF KINASE; GENE PRODUCT; PROTEIN RET; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CHERNOBYL ACCIDENT; CHILD; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PAPILLARY CARCINOMA; POINT MUTATION; PREVALENCE; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; SEQUENCE ANALYSIS; THYROID CARCINOMA;

ADOLESCENT; ADULT; CARCINOMA, PAPILLARY; CHILD; HUMANS; MUTATION; NEOPLASMS, RADIATION-INDUCED; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RAF; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; TEMPERATURE; THYROID NEOPLASMS;

EID: 2442642971     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2003.12.004     Document Type: Article

References (19)

1. Kimura E.T., Nikiforova M.N., Zhu Z., Knauf J.A., Nikiforov Y.E., Fagin J.A. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res. 63:2003;1454-1457
2. Soares P., Trovisco V., Rocha A.S., Lima J., Castro P., Preto A., Maximo V., Botelho T., Seruca R., Sobrinho-Simoes M., mutations B.R.A.F. Sobrinho-Simoes, BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. Oncogene. 22:2003;4578-4580
3. Cohen Y., Xing M., Mambo E., Guo Z., Wu G., Trink B., Beller U., Westra W.H., Ladenson P.W., Sidransky D. BRAF Mutation in Papillary Thyroid Carcinoma. J. Natl. Cancer Inst. 95:2003;625-627
4. Xu X., Quiros R.M., Gattuso P., Ain K.B., Prinz R.A. High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. Cancer Res. 63:2003;4561-4567
5. Namba H., Nakashima M., Hayashi T., Hayashida N., Maeda S., Rogounovitch T.I., Ohtsuru A., Saenko V.A., Kanematsu T., Yamashita S. Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers. J. Clin. Endocrinol. Metab. 88:2003;4393-4397
6. Fukushima T., Suzuki S., Mashiko M., Ohtake T., Endo Y., Takebayashi Y., Sekikawa K., Hagiwara K., Takenoshita S., mutations B.R.A.F. BRAF mutaions in papillary carcinomas of the thyroid. Oncogene. 22:2003;6455-6457
7. Kazakov V.S., Demidchik E.P., Astakhova L.N. Thyroid cancer after Chernobyl. Nature. 359:1992;21
8. Stsjazhko V.A., Tsyb A.F., Tronko N.D., Souchkevitch G., Baverstock K.F. Childhood thyroid cancer since accident at Chernobyl. Br. Med. J. 310:1995;801
9. Tuttle R.M., Becker D.V. The Chernobyl accident and its consequences: update at the millennium. Semin. Nucl. Med. 30:2000;133-140
10. Fugazzola L., Pilotti S., Pinchera A., Vorontsova T.V., Mondellini P., Bongarzone I., Greco A., Astakhova L., Butti M.G., Demidchik E.P., et al. Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident. Cancer Res. 55:1995;5617-5620
11. Klugbauer S., Lengfelder E., Demidchik E.P., Rabes H.M. High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident. Oncogene. 11:1995;2459-2467
12. Nikiforov Y.E., Rowland J.M., Bove K.E., Monforte-Munoz H., Fagin J.A. Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Res. 57:1997;1690-1694
13. Smida J., Salassidis K., Hieber L., Zitzelsberger H., Kellerer A.M., Demidchik E.P., Negele T., Spelsberg F., Lengfelder E., Werner M., Bauchinger M. Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus. Int. J. Cancer. 80:1999;32-38
14. Thomas G.A., Bunnell H., Cook H.A., Williams E.D., Nerovnya A., Cherstvoy E.D., Tronko N.D., Bogdanova T.I., Chiappetta G., Viglietto G., Pentimalli F., Salvatore G., Fusco A., Santoro M., Vecchio G. High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant. J. Clin. Endocrinol. Metab. 84:1999;4232-4238
15. Rabes H.M., Demidchik E.P., Sidorow J.D., Lengfelder E., Beimfohr C., Hoelzel D., Klugbauer S. Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications. Clin. Cancer Res. 6:2000;1093-1103
16. Nikiforov Y.E., Nikiforova M.N., Gnepp D.R., Fagin J.A. Prevalence of mutations of ras and p53 in benign and malignant thyroid tumors from children exposed to radiation after the Chernobyl nuclear accident. Oncogene. 13:1996;687-693
17. Nikiforova M.N., Caudill C.M., Biddinger P., Nikiforov Y.E. Prevalence of RET/PTC Rearrangements in Hashimoto's Thyroiditis and Papillary Thyroid Carcinomas. Int. J. Surg. Pathol. 10:2002;15-22
18. M.N. Nikiforova, K.E.T., M. Gandhi, P.B. Biddinger, J.A. Knauf, F. Basolo, R. Giannini, G. Salvatore, A. Fusco, M. Santoro, J.A. Fagin, Y.E. Nikiforov, BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas, J. Clin. Endocrinol. Metab. 88 (2003) 5399-5404.
19. Basolo F., Giannini R., Monaco C., Melillo R.M., Carlomagno F., Pancrazi M., Salvatore G., Chiappetta G., Pacini F., Elisei R., Miccoli P., Pinchera A., Fusco A., Santoro M. Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma. Am. J. Pathol. 160:2002;247-254