Garlic attenuates nitric oxide production in rat cardiac myocytes through inhibition of inducible nitric oxide synthase and the arginine transporter CAT-2 (cationic amino acid transporter-2)

Clinical Science

Volumn 102, Issue 5, 2002, Pages 487-493

  Schwartz, Idit F ^a   Hershkovitz, Rami ^a   Iaina, Adrian ^a   Gnessin, Ehud ^a   Wollman, Yoram ^a   Chernichowski, Tamara ^a   Blum, Miriam ^a   Levo, Yoram ^a   Schwartz, Doron ^a  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

Allicin; Arginine transport; CAT 1; CAT 2; Myocytes; Nitric oxide synthase

Indexed keywords

ALLICIN; ANTIOXIDANT; ARGININE; CARRIER PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; ENZYME INHIBITION; GARLIC; HEART MUSCLE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

ANIMALS; ARGININE; CATIONIC AMINO ACID TRANSPORTER 1; CATIONIC AMINO ACID TRANSPORTER 2; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GARLIC; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; RNA, MESSENGER; SULFINIC ACIDS;

EID: 0036257570     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20010221     Document Type: Article

References (33)

1. Allium sativum (garlic), a natural antibiotic
2. Inhibition of growth of Entamoeba histolitica by allicin, the active principle of garlic extract (Allium sativum)
3. The mode of action of allicin: Trapping of radicals and interaction with thiol containing proteins
4. Effects of garlic preparations on superoxide production by phorbol ester activated granulocytes
5. Antioxidant activity of allicin, an active principle in garlic
6. Nitric oxide synthase isoenzymes. Characterization, purification, molecular cloning, and functions
7. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly
8. Induction of nitric oxide gene by interleukin-1b in cultured rat cardiocytes
9. The lethal effects of cytokine induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor β
10. Potent activation of nitric oxide synthase by garlic: A basis for its therapeutic applications
11. Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase
12. Functional integrity of isolated rat hepatocytes prepared by whole liver vs biopsy perfusion
13. Killing of Plasmodium falciparum in vitro by nitric oxide derivatives
14. A rapid method for the assay of nitrate in the urine using the nitrate reductase enzyme of E. coli
15. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
16. Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine
17. Amplification of human minisatellites by the polymerase chain reaction: Towards DNA fingerprinting of single cells
18. Adaptive regulation of the cationic amino acid transporter-1 (cat-1) in Fao cells
19. Induced nitric oxide synthesis is dependent on induced alternatively spliced CAT-2 encoding L-arginine transport in brain astrocytes
20. Location of an inducible nitric oxide synthase mRNA in the normal kidney
21. The cluster-tray method for rapid measurement of solute fluxes in adherent cultured cells
22. Sustained nitric oxide production in macrophages requires the arginine transporter CAT-2
23. Arginine is not responsible for the activation of nitric oxide synthase by garlic
24. The two way flux of cationic amino acids across the plasma membrane of mammalian cells is largely explained by a single transport system
25. Cationic amino acid transport into cultured animal cells. 1. Influx into cultured human fibroblasts
26. A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection
27. Transport of cationic amino acids by the mouse ecotropic retrovirus receptor
28. Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor
29. Cell surface receptor for the ecotropic murine retroviruses is a basic amino acid
30. Cytokines and insulin induce cationic amino acid transporter (CAT) in cardiac mvocytes. Regulation of L-arginine transport and NO production by CAT-1, CAT-2A, and CAT-2B
31. Cutting edge: State-dependent substrate depletion regulates nitric oxide production
32. Regulation of intracellular polyamine biosynthesis and transport by NO and cytokines TNF-alpha and IFN-gamma
33. Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats