CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes

American Journal of Respiratory Cell and Molecular Biology

Volumn 38, Issue 6, 2008, Pages 671-678

  Watson, Patricia M ^a,b   Miller, Scott W ^a   Fraig, Mostafa ^a   Cole, David J ^a   Watson, Dennis K ^a   Boylan, Alice M ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

CaSm; Lung cancer; Mesothelioma; Sm protein; Transformation

Indexed keywords

MESSENGER RNA;

ANIMAL CELL; ARTICLE; CANCER ASSOCIATED SM LIKE GENE; CANCER GROWTH; CELL GROWTH; CELL LINE; CELL TRANSFORMATION; COLONY FORMATION; COMPARATIVE STUDY; CONTROLLED STUDY; EPITHELIUM; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LUNG CANCER; LUNG PARENCHYMA; MESOTHELIOMA; MOUSE; NONHUMAN; ONCOGENE; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR GROWTH; WESTERN BLOTTING;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MESOTHELIOMA; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; PHENOTYPE; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE; RNA-BINDING PROTEINS;

MUS;

EID: 45249099975     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2007-0205OC     Document Type: Article

References (31)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43-66.
2. Jett JR, Miller YE. Update in lung cancer 2005. Am J Respir Crit Care Med 2006;173:695-697.
3. Visbal AL, Williams BA, Nichols FC III, Marks RS, Jett JR, Aubry MC, Edell ES, Wampfler JA, Molina JR, Yang P. Gender differences in non-small-cell lung cancer survival: an analysis of 4,618 patients diagnosed between 1997 and 2002. Ann Thorac Surg 2004;78:209-215. (discussion 215).
4. Henschke CI, Yankelevitz DF, Libby DM, Pasmantier MW, Smith JP, Miettinen OS. Survival of patients with stage 1 lung cancer detected on ct screening. N Engl J Med 2006;355:1763-1771.
5. Bach PB, Jett JR, Pastorino U, Tockman MS, Swensen SJ, Begg CB. Computed tomography screening and lung cancer outcomes. JAMA 2007;297:953-961.
6. Robinson BW, Lake RA. Advances in malignant mesothelioma. N Engl J Med 2005;353:1591-1603.
7. Bocchetta M, Di Resta I, Powers A, Fresco R, Tosolini A, Testa JR, Pass HI, Rizzo P, Carbone M. Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity. Proc Natl Acad Sci USA 2000;97:10214-10219.
8. Wong L, Zhou J, Anderson D, Kratzke RA. Inactivation of p16ink4a expression in malignant mesothelioma by methylation. Lung Cancer 2002;38:131-136.
9. Masood R, Kundra A, Zhu S, Xia G, Scalia P, Smith DL, Gill PS. Malignant mesothelioma growth inhibition by agents that target the vegf and vegf-c autocrine loops. Int J Cancer 2003;104:603-610.
10. Dhaene K, Wauters J, Weyn B, Timmermans JP, van Marck E. Expression profile of telomerase subunits in human pleural mesothelioma. J Pathol 2000;190:80-85.
11. Broaddus VC, Dansen TB, Abayasiriwardana KS, Wilson SM, Finch AJ, Swigart LB, Hunt AE, Evan GI. Bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (trail) and DNA damage. J Biol Chem 2005;280:12486-12493.
12. Schweinfest CW, Graber MW, Chapman JM, Papas TS, Baron PL, Watson DK. Casm: An sm-like protein that contributes to the transformed state in cancer cells. Cancer Res 1997;57:2961-2965.
13. Fraser MM, Watson PM, Fraig MM, Kelley JR, Nelson PS, Boylan AM, Cole DJ, Watson DK. Casm-mediated cellular transformation is associated with altered gene expression and messenger rna stability. Cancer Res 2005;65:6228-6236.
14. He W, Parker R. Functions of lsm proteins in mrna degradation and splicing. Curr Opin Cell Biol 2000;12:346-350.
15. Sheth U, Parker R. Decapping and decay of messenger rna occur in cytoplasmic processing bodies. Science 2003;300:805-808.
16. Sheth U, Parker R. Targeting of aberrant mrnas to cytoplasmic processing bodies. Cell 2006;125:1095-1109.
17. Eystathioy T, Jakymiw A, Chan EK, Seraphin B, Cougot N, Fritzler MJ. The gw182 protein colocalizes with mrna degradation associated proteins hdcp1 and hlsm4 in cytoplasmic gw bodies. RNA 2003;9:1171-1173.
18. Beggs JD. Lsm proteins and rna processing. Biochem Soc Trans 2005;33:433-438.
19. van Dijk E, Cougot N, Meyer S, Babajko S, Wahle E, Seraphin B. Human dcp2: a catalytically active mrna decapping enzyme located in specific cytoplasmic structures. EMBO J 2002;21:6915-6924.
20. Zaric B, Chami M, Remigy H, Engel A, Ballmer-Hofer K, Winkler FK, Kambach C. Reconstitution of two recombinant lsm protein complexes reveals aspects of their architecture, assembly, and function. J Biol Chem 2005;280:16066-16075.
21. Paddison PJ, Caudy AA, Bernstein E, Hannon GJ, Conklin DS. Short hairpin rnas (shrnas) induce sequence-specific silencing in mammalian cells. Genes Dev 2002;16:948-958.
22. Paddison PJ, Hannon GJ. Rna interference: the new somatic cell genetics? Cancer Cell 2002;2:17-23.
23. Kelley JR, Fraser MM, Schweinfest CW, Vournakis JN, Watson DK, Cole DJ. Casm/gemcitabine chemo-gene therapy leads to prolonged survival in a murine model of pancreatic cancer. Surgery 2001;130:280-288.
24. Kelley JR, Brown JM, Frasier MM, Baron PL, Schweinfest CW, Vournakis JN, Watson DK, Cole DJ. The cancer-associated sm-like oncogene: a novel target for the gene therapy of pancreatic cancer. Surgery 2000;128:353-360.
25. Fedorov Y, Anderson EM, Birmingham A, Reynolds A, Karpilow J, Robinson K, Leake D, Marshall WS, Khvorova A. Off-target effects by sirna can induce toxic phenotype. RNA (New York, NY 2006;12:1188-1196.
26. Yan Y, Rubinchik S, Watson PM, Kelley JR, Fraser MM, Wood AL, Dong JY, Gillanders WE, Boylan AM, Watson DK, et al. Establishing a murine pancreatic cancer casm model: up-regulation of casm is required for the transformed phenotype of murine pancreatic adenocarcinoma. Mol Ther 2005;11:363-372.
27. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
28. Rangarajan A, Hong SJ, Gifford A, Weinberg RA. Species- and cell type-specific requirements for cellular transformation. Cancer Cell 2004;6:171-183.
29. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999;400:464-468.
30. Boeck R, Lapeyre B, Brown CE, Sachs AB. Capped mrna degradation intermediates accumulate in the yeast spb8-2 mutant. Mol Cell Biol 1998;18:5062-5072.
31. Streicher KL, Yang ZQ, Draghici S, Ethier SP. Transforming function of the lsm1 oncogene in human breast cancers with the 8p11-12 amplicon. Oncogene 2007;26:2104-2114.