CaSm/gemcitabine chemo-gene therapy leads to prolonged survival in a murine model of pancreatic cancer

Surgery

Volumn 130, Issue 2, 2001, Pages 280-288

  Kelley, Joseph R ^a   Fraser, Melissa M ^a   Schweinfest, Clifford W ^a   Vournakis, John N ^a   Watson, Dennis K ^a   Cole, David J ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; COMPLEMENTARY RNA; ETOPOSIDE; GEMCITABINE; GENE PRODUCT; PROTEIN CASM; UNCLASSIFIED DRUG;

ADENOVIRUS; ARTICLE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER SURVIVAL; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; PANCREAS CARCINOMA; PRIORITY JOURNAL;

EID: 0034902935     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1067/msy.2001.115899     Document Type: Article

References (19)

1. Pancreatic cancer: State-of-the-art care
2. Cancer statistics, 1998
3. Adenovirus-mediated wildtype p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer
4. Directed anti-sense therapy confirms the role of protein kinase C-alpha in the tumorigenicity of pancreatic cancer
5. Gene therapy for pancreatic carcinoma: Local and distant antitumor effects after somatostatin receptor sst2 gene transfer
6. The dominant negative H-ras mutant, N116Y, suppresses growth of metastatic human pancreatic cancer cells in the liver of nude mice
7. Isolation and characterization of novel genes with elevated expression in pancreatic cancer
8. CaSm: An Sm-like protein that contributes to the transformed state in cancer cells
9. The cancer-associated Sm-like oncogene: A novel target for the gene therapy of pancreatic cancer
10. The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12
11. Sensitivity and reproducibility in adenoviral infectious titer determination
12. KRAS oncogene mutations suggest a common histogenetic origin for pleomorphic giant cell tumor of the pancreas, osteoclastoma of the pancreas, and pancreatic duct adenocarcinoma
13. Reversal of the malignant phenotype by an anti-ras ribozyme
14. A Sm-like protein complex that participates in mRNA degradation
15. Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin
16. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3′-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro
17. Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant
18. mRNA stability, in eukaryotes
19. Functions of Lsm proteins in mRNA degradation and splicing