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Volumn 12, Issue 3, 2000, Pages 346-350

Functions of Lsm proteins in mRNA degradation and splicing

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR PROTEIN;

EID: 0034103227     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00098-3     Document Type: Review
Times cited : (148)

References (29)
  • 1
    • 0028202495 scopus 로고
    • Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5′→3′ digestion of the transcript
    • Muhlrad D., Decker C.J., Parker R. Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5′→3′ digestion of the transcript. Genes Dev. 8:1994;855-866.
    • (1994) Genes Dev , vol.8 , pp. 855-866
    • Muhlrad, D.1    Decker, C.J.2    Parker, R.3
  • 2
    • 0028961870 scopus 로고
    • Turnover mechanisms of the stable yeast PGK1 mRNA
    • Muhlrad D., Decker C.J., Parker R. Turnover mechanisms of the stable yeast PGK1 mRNA. Mol Cell Biol. 15:1995;2145-2156.
    • (1995) Mol Cell Biol , vol.15 , pp. 2145-2156
    • Muhlrad, D.1    Decker, C.J.2    Parker, R.3
  • 3
    • 0031841817 scopus 로고    scopus 로고
    • Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant
    • Boeck R., Lapeyre B., Brown C.E., Sachs A.B. Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant. Mol Cell Biol. 18:1998;5062-5072.
    • (1998) Mol Cell Biol , vol.18 , pp. 5062-5072
    • Boeck, R.1    Lapeyre, B.2    Brown, C.E.3    Sachs, A.B.4
  • 4
    • 85031643781 scopus 로고    scopus 로고
    • Sm-like proteins function in mRNA decay
    • in press. This work demonstrates that a cytoplasmic Lsm complex interacts with mRNA and mRNA decay factors. In addition, it shows that the Lsm complex functions in mRNA decay by activating decapping.
    • Tharun S., He W., Mayes A.E., Lennertz P., Beggs J.D., Parker R. Sm-like proteins function in mRNA decay. Nature. 2000;. in press. This work demonstrates that a cytoplasmic Lsm complex interacts with mRNA and mRNA decay factors. In addition, it shows that the Lsm complex functions in mRNA decay by activating decapping.
    • (2000) Nature
    • Tharun, S.1    He, W.2    Mayes, A.E.3    Lennertz, P.4    Beggs, J.D.5    Parker, R.6
  • 5
    • 0028997105 scopus 로고
    • Sm and Sm-like proteins belong to a large family: Identification of proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs
    • Seraphin B. Sm and Sm-like proteins belong to a large family: identification of proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs. EMBO J. 14:1995;2089-2098.
    • (1995) EMBO J , vol.14 , pp. 2089-2098
    • Seraphin, B.1
  • 6
    • 0029054377 scopus 로고
    • SnRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions
    • Hermann H., Fabrizio P., Raker V.A., Foulaki K., Hornig H., Brahms H., Luhrmann R. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. EMBO J. 14:1995;2076-2088.
    • (1995) EMBO J , vol.14 , pp. 2076-2088
    • Hermann, H.1    Fabrizio, P.2    Raker, V.A.3    Foulaki, K.4    Hornig, H.5    Brahms, H.6    Luhrmann, R.7
  • 7
    • 0030963019 scopus 로고    scopus 로고
    • Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens
    • Fromont-Racine M., Rain J.C., Legrain P. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Nat Genet. 16:1997;277-282.
    • (1997) Nat Genet , vol.16 , pp. 277-282
    • Fromont-Racine, M.1    Rain, J.C.2    Legrain, P.3
  • 8
    • 0033564627 scopus 로고    scopus 로고
    • Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin
    • This paper characterizes the interaction of yeast Lsm proteins with U6 snRNA and demonstrates that Sm and Lsm proteins assemble in at least two related complexes.
    • Salgado-Garrido J., Bragado-Nilsson E., Kandels-Lewis S., Seraphin B. Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. EMBO J. 18:1999;3451-3462. This paper characterizes the interaction of yeast Lsm proteins with U6 snRNA and demonstrates that Sm and Lsm proteins assemble in at least two related complexes.
    • (1999) EMBO J , vol.18 , pp. 3451-3462
    • Salgado-Garrido, J.1    Bragado-Nilsson, E.2    Kandels-Lewis, S.3    Seraphin, B.4
  • 9
    • 0033569743 scopus 로고    scopus 로고
    • A doughnut-shaped heteromer of human Sm-like proteins binds to the 3′-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro
    • This paper demonstrates that purified human Lsm proteins form a stable doughnut-shaped structure, visualized using electron microscopy. It also demonstrates that Lsm proteins bind to the 3′ U-rich region of U6 and facilitate the formation of U4-U6 duplex.
    • Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luhrmann R. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3′-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. EMBO J. 18:1999;5789-5802. This paper demonstrates that purified human Lsm proteins form a stable doughnut-shaped structure, visualized using electron microscopy. It also demonstrates that Lsm proteins bind to the 3′ U-rich region of U6 and facilitate the formation of U4-U6 duplex.
    • (1999) EMBO J , vol.18 , pp. 5789-5802
    • Achsel, T.1    Brahms, H.2    Kastner, B.3    Bachi, A.4    Wilm, M.5    Luhrmann, R.6
  • 11
    • 0033524941 scopus 로고    scopus 로고
    • Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs
    • This paper describes the crystal structure of Sm subcomplexes and proposed a seven member ring structure for the Sm complex.
    • Kambach C., Walke S., Young R., Avis J.M., de la Fortelle E., Raker V.A., Luhrmann R., Li J., Nagai K. Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. Cell. 96:1999;375-387. This paper describes the crystal structure of Sm subcomplexes and proposed a seven member ring structure for the Sm complex.
    • (1999) Cell , vol.96 , pp. 375-387
    • Kambach, C.1    Walke, S.2    Young, R.3    Avis, J.M.4    De La Fortelle, E.5    Raker, V.A.6    Luhrmann, R.7    Li, J.8    Nagai, K.9
  • 12
    • 0030007060 scopus 로고    scopus 로고
    • The snRNP core assembly pathway: Identification of stable core protein heteromeric complexes and an snRNP subcore particle in vitro
    • Raker V.A., Plessel G., Luhrmann R. The snRNP core assembly pathway: identification of stable core protein heteromeric complexes and an snRNP subcore particle in vitro. EMBO J. 15:1996;2256-2269.
    • (1996) EMBO J , vol.15 , pp. 2256-2269
    • Raker, V.A.1    Plessel, G.2    Luhrmann, R.3
  • 13
    • 0031586612 scopus 로고    scopus 로고
    • Multiple protein: Protein interactions between the snRNP common core proteins
    • Fury M.G., Zhang W., Christodoulopoulos I., Zieve G.W. Multiple protein: protein interactions between the snRNP common core proteins. Exp Cell Res. 237:1997;63-69.
    • (1997) Exp Cell Res , vol.237 , pp. 63-69
    • Fury, M.G.1    Zhang, W.2    Christodoulopoulos, I.3    Zieve, G.W.4
  • 14
    • 0033517098 scopus 로고    scopus 로고
    • Characterization of Sm-like proteins in yeast and their association with U6 snRNA
    • Work in this paper characterizes the roles of Lsm proteins in pre-mRNA splicing. This paper also demonstrates that Lsm proteins interact with each other and suggests that Lsm proteins may function by facilitating conformational rearrangements of the U6 snRNP.
    • Mayes A.E., Verdone L., Legrain P., Beggs J.D. Characterization of Sm-like proteins in yeast and their association with U6 snRNA. EMBO J. 18:1999;4321-4331. Work in this paper characterizes the roles of Lsm proteins in pre-mRNA splicing. This paper also demonstrates that Lsm proteins interact with each other and suggests that Lsm proteins may function by facilitating conformational rearrangements of the U6 snRNP.
    • (1999) EMBO J , vol.18 , pp. 4321-4331
    • Mayes, A.E.1    Verdone, L.2    Legrain, P.3    Beggs, J.D.4
  • 15
    • 0029054375 scopus 로고
    • Identification and characterization of Uss1p (Sdb23p): A novel U6 snRNA-associated protein with significant similarity to core proteins of small nuclear ribonucleoproteins
    • Cooper M., Johnston L.H., Beggs J.D. Identification and characterization of Uss1p (Sdb23p): a novel U6 snRNA-associated protein with significant similarity to core proteins of small nuclear ribonucleoproteins. EMBO J. 14:1995;2066-2075.
    • (1995) EMBO J , vol.14 , pp. 2066-2075
    • Cooper, M.1    Johnston, L.H.2    Beggs, J.D.3
  • 16
    • 0032535451 scopus 로고    scopus 로고
    • A role for the yeast La protein in U6 snRNP assembly: Evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts
    • Pannone B.K., Xue D., Wolin S.L. A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts. EMBO J. 17:1998;7442-7453.
    • (1998) EMBO J , vol.17 , pp. 7442-7453
    • Pannone, B.K.1    Xue, D.2    Wolin, S.L.3
  • 17
    • 0033575711 scopus 로고    scopus 로고
    • Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP
    • Gottschalk A., Neubauer G., Banroques J., Mann M., Luhrmann R., Fabrizio P. Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J. 18:1999;4535-4548.
    • (1999) EMBO J , vol.18 , pp. 4535-4548
    • Gottschalk, A.1    Neubauer, G.2    Banroques, J.3    Mann, M.4    Luhrmann, R.5    Fabrizio, P.6
  • 18
    • 0033595016 scopus 로고    scopus 로고
    • Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins
    • Stevens S.W., Abelson J. Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci USA. 96:1999;7226-7231.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7226-7231
    • Stevens, S.W.1    Abelson, J.2
  • 19
    • 0032489021 scopus 로고    scopus 로고
    • Mechanical devices of the spliceosome: Motors, clocks, springs, and things
    • Staley J.P., Guthrie C. Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell. 92:1998;315-326.
    • (1998) Cell , vol.92 , pp. 315-326
    • Staley, J.P.1    Guthrie, C.2
  • 20
    • 0033214061 scopus 로고    scopus 로고
    • The DCP2 protein is required for mRNA decapping in saccharomyces cerevisiae and contains a functional MutT motif
    • Dunckley T., Parker R. The DCP2 protein is required for mRNA decapping in saccharomyces cerevisiae and contains a functional MutT motif. EMBO J. 18:1999;5411-5422.
    • (1999) EMBO J , vol.18 , pp. 5411-5422
    • Dunckley, T.1    Parker, R.2
  • 21
    • 0029791555 scopus 로고    scopus 로고
    • Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae
    • Hatfield L., Beelman C.A., Stevens A., Parker R. Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae. Mol Cell Biol. 16:1996;5830-5838.
    • (1996) Mol Cell Biol , vol.16 , pp. 5830-5838
    • Hatfield, L.1    Beelman, C.A.2    Stevens, A.3    Parker, R.4
  • 22
    • 0032778953 scopus 로고    scopus 로고
    • Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae
    • Schwartz D.C., Parker R. Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae. Mol Cell Biol. 19:1999;5247-5256.
    • (1999) Mol Cell Biol , vol.19 , pp. 5247-5256
    • Schwartz, D.C.1    Parker, R.2
  • 23
    • 0033055772 scopus 로고    scopus 로고
    • The cis acting sequences responsible for the differential decay of the unstable MFA2 and stable PGK1 transcripts in yeast include the context of the translational start codon
    • LaGrandeur T., Parker R. The cis acting sequences responsible for the differential decay of the unstable MFA2 and stable PGK1 transcripts in yeast include the context of the translational start codon. RNA. 5:1999;420-433.
    • (1999) RNA , vol.5 , pp. 420-433
    • Lagrandeur, T.1    Parker, R.2
  • 24
    • 0032741067 scopus 로고    scopus 로고
    • Recognition of yeast mRNAs as 'nonsense containing' leads to both inhibition of mRNA translation and mRNA degradation: Implications for the control of mRNA decapping
    • Mulhrad D., Parker R. Recognition of yeast mRNAs as 'nonsense containing' leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping. Mol Biol Cell. 10:1999;3971-3978.
    • (1999) Mol Biol Cell , vol.10 , pp. 3971-3978
    • Mulhrad, D.1    Parker, R.2
  • 25
  • 26
    • 0032755703 scopus 로고    scopus 로고
    • Characterization of U6 snRNA-protein interactions
    • Vidal V.P.I., Verdone L., Mayes A.E., Beggs J.D. Characterization of U6 snRNA-protein interactions. RNA. 5:1999;1470-1481.
    • (1999) RNA , vol.5 , pp. 1470-1481
    • Vidal, V.P.I.1    Verdone, L.2    Mayes, A.E.3    Beggs, J.D.4
  • 28
    • 0033974688 scopus 로고    scopus 로고
    • Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins
    • Ito T., Tashiro K., Muta S., Ozawa R., Chiba T., Nishizawa M., Yamamoto K., Kuhara S., Sakaki Y. Toward a protein-protein interaction map of the budding yeast: a comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Proc Natl Acad Sci USA. 97:2000;1143-1147.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1143-1147
    • Ito, T.1    Tashiro, K.2    Muta, S.3    Ozawa, R.4    Chiba, T.5    Nishizawa, M.6    Yamamoto, K.7    Kuhara, S.8    Sakaki, Y.9
  • 29
    • 0034635982 scopus 로고    scopus 로고
    • Identification and characterization of a host protein required for efficient template selelction in viral RNA replication
    • in press.
    • Diez J., Ishikawa M., Kaido M., Ahlquist P. Identification and characterization of a host protein required for efficient template selelction in viral RNA replication. Proc Natl Acad Sci USA. 2000;. in press.
    • (2000) Proc Natl Acad Sci USA
    • Diez, J.1    Ishikawa, M.2    Kaido, M.3    Ahlquist, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.