MyD88-induced downregulation of IRAK-4 and its structural requirements

FEMS Immunology and Medical Microbiology

Volumn 53, Issue 2, 2008, Pages 260-264

  Hatao, Fumihiko ^a,b   Yamamoto, Maya ^b   Muroi, Masashi ^b   Kaminishi, Michio ^a   Tanamoto, Ken Ichi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

IL 1 receptor; NF B; Toll like receptor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; MYELOID DIFFERENTIATION FACTOR 88;

ARTICLE; CELL STRAIN HEK293; DELETION MUTANT; DOWN REGULATION; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; CELL LINE; DOWN-REGULATION; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION;

EID: 45149109955     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2008.00425.x     Document Type: Article

References (22)

1. Burns K, Janssens S, Brissoni B, Olivos N, Beyaert R Tschopp J (2003) Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med 197 : 263 268.
2. Cao Z, Xiong J, Takeuchi M, Kurama T Goeddel DV (1996) TRAF6 is a signal transducer for interleukin-1. Nature 383 : 443 446.
3. Dobrovolskaia MA, Medvedev AE, Thomas KE, Cuesta N, Toshchakov V, Ren T, Cody MJ, Michalek SM, Rice NR Vogel SN (2003) Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-κB signaling pathway components. J Immunol 170 : 508 519.
4. Fujihara M, Muroi M, Tanamoto K, Suzuki T, Azuma H Ikeda H (2003) Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther 100 : 171 194.
5. Hatao F, Muroi M, Hiki N, Ogawa T, Mimura Y, Kaminishi M Tanamoto K (2004) Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein. J Leukoc Biol 76 : 904 908.
6. Jacinto R, Hartung T, McCall C Li L (2002) Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase. J Immunol 168 : 6136 6141.
7. Janssens S Beyaert R (2003) Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol Cell 11 : 293 302.
8. Kanakaraj P, Schafer PH, Cavender DE et al 1998) Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production. J Exp Med 187 : 2073 2079.
9. Kawagoe T, Sato S, Jung A, Yamamoto M, Matsui K, Kato H, Uematsu S, Takeuchi O Akira S (2007) Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J Exp Med 204 : 1013 1024.
10. Kim TW, Staschke K, Bulek K et al 2007) A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J Exp Med 204 : 1025 1036.
11. Koziczak-Holbro M, Joyce C, Gluck A, Kinzel B, Muller M, Tschopp C, Mathison JC, Davis CN Gram H (2007) IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression. J Biol Chem 282 : 13552 13560.
12. Li S, Strelow A, Fontana EJ Wesche H (2002) IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci USA 99 : 5567 5572.
13. Lye E, Mirtsos C, Suzuki N, Suzuki S Yeh WC (2004) The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem 279 : 40653 40658.
14. Medvedev AE, Thomas K, Awomoyi A, Kuhns DB, Gallin JI, Li X Vogel SN (2005) Expression of IL-1 receptor-associated kinase-4 (IRAK-4) proteins with mutations identified in a patient with recurrent bacterial infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex. J Immunol 174 : 6587 6591.
15. Muroi M Tanamoto K (2002) The polysaccharide portion plays an indispensable role in Salmonella lipopolysaccharide-induced activation of NF-κB through human Toll-like receptor 4. Infect Immun 70 : 6043 6047.
16. Muroi M, Ohnishi T Tanamoto K (2002) MD-2, a novel accessory molecule, is involved in species-specific actions of Salmonella lipid A. Infect Immun 70 : 3546 3550.
17. Picard C, Puel A, Bonnet M et al 2003) Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 299 : 2076 2079.
18. Qin J, Jiang Z, Qian Y, Casanova JL Li X (2004) IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness. J Biol Chem 279 : 26748 26753.
19. Sato S, Takeuchi O, Fujita T, Tomizawa H, Takeda K Akira S (2002) A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. Int Immunol 14 : 783 791.
20. Suzuki N, Suzuki S, Duncan GS et al 2002) Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416 : 750 756.
21. Thomas JA, Allen JL, Tsen M, Dubnicoff T, Danao J, Liao XC, Cao Z Wasserman SA (1999) Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol 163 : 978 984.
22. Yeo SJ, Yoon JG, Hong SC Yi AK (2003) CpG DNA induces self and cross-hyporesponsiveness of RAW264.7 cells in response to CpG DNA and lipopolysaccharide: alterations in IL-1 receptor-associated kinase expression. J Immunol 170 : 1052 1061.