Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline

Toxicology and Applied Pharmacology

Volumn 230, Issue 2, 2008, Pages 227-234

  Wang, Jianling ^a   Wang, Gangduo ^a   Ansari, G A S ^a   Khan, M Firoze ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Aniline; AP 1; Cytokines; IKK; MAPK; NF B; Oxidative stress; Spleen

Indexed keywords

ANILINE; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; PROTEIN SUBUNIT; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROSIS; GENETIC TRANSCRIPTION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SPLEEN CELL; WESTERN BLOTTING;

ANILINE COMPOUNDS; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CYTOKINES; I-KAPPA B KINASE; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPLENIC DISEASES; TRANSCRIPTION FACTOR AP-1;

RATTUS;

EID: 45049086497     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.02.022     Document Type: Article

References (71)

1. Abate C., Patel L., Rauscher III F.J., and Curran T. Redox regulation of fos and jun DNA-binding activity in vitro. Science 249 (1990) 1157-1161
2. Akira S., and Kishimoto T. NF-IL6 and NF-kB in cytokine gene regulation. Adv. Immunol. 65 (1997) 1-46
3. Angel P., and Karin M. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochim. Biophys. Acta 1072 (1991) 129-157
4. Baldwin A.S. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14 (1996) 649-683
5. Bus J.S., and Popp J.A. Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally related compounds. Food Chem. Toxicol. 25 (1987) 619-626
6. Castrillo A., de Las Heras B., Hortelano S., Rodriguez B., Villar A., and Bosca L. Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK. J. Biol. Chem. 276 (2001) 15854-15860
7. Chen Z., Hagler J., Palombella V.J., Melandri F., Schere D., Ballard D., and Maniatis T. Signal-induced site-specific phosphorylation targets IkBα to the ubiquitin- proteasome pathway. Genes Dev. 9 (1995) 1586-1597
8. Chen C.Y., Huang Y.L., and Lin T.H. Association between oxidative stress and cytokine production in nickel-treated rats. Arch. Biochem. Biophys. 356 (1998) 127-132
9. Chen F., Castranova V., Shi X., and Demers L.M. New insights into the role of nuclear factor-kB, a ubiquitous transcription factor in the initiation of diseases. Clin.Chem. 45 (1999) 7-17
10. Ciccoli L., Ferrali M., Rossi V., Signorini C., Alessandrini C., and Comporti M. Hemolytic drugs aniline and dapsone induce iron release in erythrocytes and increase the free iron pool in spleen and liver. Toxicol. Lett. 110 (1999) 57-66
11. Dai J., Huang C., Wu J., Yang C., Frenkel K., and Huang X. Iron-induced interleukin-6 gene expression: possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. Toxicology 203 (2004) 199-209
12. Elias J.A., Freundlich B., Kern J.A., and Rosenbloom J. Cytokine networks in the regulation of inflammation and fibrosis in the lung. Chest 97 (1990) 1439-1445
13. Filosto M., Tonin P., Vattemi G., Savio C., Rizzuto N., and Tomelleri G. Transcription factors c-Jun/activator protein-1 and nuclear factor-kappa B in oxidative stress response in mitochondrial diseases. Neuropathol. Appl. Neurobiol. 29 (2003) 52-59
14. Gius D., Botero A., Shah S., and Curry H.A. Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1. Toxicol. Lett. 106 (1999) 93-106
15. Goodman D.G., Ward J.M., and Reichardt W.D. Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4′-sulfonyldianiline, or DRC Red No. 9. J. Natl. Cancer Inst. 73 (1984) 265-273
16. Haddad J.J., Olver R.E., and Land S.C. Antioxidant/pro-oxidant equilibrium regulates HIF-1alpha and NF-kappa B redox sensitivity. Evidence for inhibition by glutathione oxidation in alveolar epithelial cells. J. Biol. Chem. 275 (2000) 21130-21139
17. Hirota K., Matsui M., Iwata S., Nishiyama A., Mori K., and Yodoi J. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 3633-3638
18. Hsieh C.C., Rosenblatt J.I., and Papaconstantinou J. Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3- nitropropionic acid. Mech. Ageing Dev. 124 (2003) 733-746
19. Hsu T.C., Young M.R., Cmarik J., and Colburn N.H. Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis. Free Radic. Biol. Med. 28 (2000) 1338-1348
20. Huang C., Li J., Zhang Q., and Huang X. Role of bioavailable iron in coal dust-induced activation of activator protein-1 and nuclear factor of activated T cells. Difference between Pennsylvania and Utah coal dusts. Am. J. Respir. Cell Mol. Biol. 27 (2002) 568-574
21. Janssen Y.M.B., Van Houten B., Borm P.J., and Mossman B.T. Cell and tissue responses to oxidative damage. Lab. Invest. 69 (1993) 261-274
22. Jenkins F.P., Robinson J.A., Gellatly J.B.M., and Salmond G.W.A. The no-effect dose of aniline in human subjects and a comparison of aniline toxicity in man and in the rat. Food Chem. Toxicol. 10 (1972) 671-679
23. Kapahi P., Takahashi T., Natoli G., Adams S.R., Chen Y., Tsien R.Y., and Karin M. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J. Biol. Chem. 275 (2000) 36062-36066
24. Kamata H., Manabe T., Oka S., Kamata K., and Hirata H. Hydrogen peroxide activates IkB kinases through phosphorylation of serine residues in the activation loops. FEBS Lett. 519 (2002) 231-237
25. Karin M. The beginning of the end: IkB kinase (IKK) and NF-kB activation. J. Biol. Chem. 274 (1999) 27339-27342
26. Karin M., and Delhase M. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signaling. Semin. Immunol. 12 (2000) 85-98
27. Kefaloyianni E., Gaitanaki C., and Beis I. ERK1/2 and p38-MAPK signaling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts. Cell. Signal. 18 (2006) 2238-2251
28. Khan M.F., Kaphalia B.S., Boor P.J., and Ansari G.A.S. Subchronic toxicity of aniline hydrochloride in rats. Arch. Environ. Contant. Toxicol. 24 (1993) 368-374
29. Khan M.F., Boor P.J., Kaphalia B.S., Alcock N.W., and Ansari G.A.S. Hematopoietic toxicity of linoleic acid anilide: importance of aniline. Fundam. Appl. Toxicol. 25 (1995) 224-232
30. Khan M.F., Gu Y., Alcock N.W., Boor P.J., and Ansari G.A.S. Oxidative stress in splenotoxicity of aniline. Fundam. Appl. Toxicol. 35 (1997) 22-30
31. Khan M.F., Wu X., Kaphalia B.S., Boor P.J., and Ansari G.A.S. Acute hematopoietic toxicity of aniline in rats. Toxicol. Lett. 92 (1997) 31-37
32. Khan M.F., Wu X., Boor P.J., and Ansari G.A.S. Oxidative modification of proteins and lipids in aniline-induced splenic toxicity. Toxicol. Sci. 48 (1999) 134-140
33. Khan M.F., Wu X., Alcock N.W., Boor P.J., and Ansari G.A.S. Iron exacerbates aniline-associated splenic toxicity. J. Toxicol. Environ. Health 57 (1999) 173-184
34. Khan M.F., Wu X., Ansari G.A.S., and Boor P.J. Malondialdehyde-protein adducts in the spleens of aniline-treated rats: immunohistochemical detection and localization. J. Toxicol. Environ. Health, Part A 66 (2003) 93-102
35. Khan M.F., Wu X., and Wang J. Up-regulation of transforming growth factor-b1 in the spleen of aniline-treated rats. Toxicol. Appl. Pharmacol. 187 (2003) 22-28
36. Khan M.F., Wu X., Kaphalia B.S., Boor P.J., and Ansari G.A.S. Nitrotyrosine formation in splenic toxicity of aniline. Toxicology 194 (2003) 95-102
37. Khan M.F., Kannan S., and Wang J. Activation of transcription factor AP-1 and mitogen-activated protein kinases in aniline-induced splenic toxicity. Toxicol. Appl. Pharmacol. 210 (2006) 86-93
38. Klaunig J.E., and Kamendulis L.M. The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 44 (2004) 239-267
39. Kontny E., Ziolkowska M., Ryzewska A., and Maliski W. Protein kinase C-dependent pathway is critical for the production of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6). Cytokine 11 (1999) 839-848
40. Lahdenpohja N., Savinainen K., and Hurme M. Pre-exposure to oxidative stress decreases the nuclear factor-kappa B-dependent transcription in T lymphocytes. Immunology 160 (1998) 1354-1358
41. Lee F.S., Hagler J., Chen Z.J., and Maniatis T. Activation of the IkB-α kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88 (1997) 213-222
42. Lee J.Y., Yu B.P., and Chung H.Y. Activation mechanisms of endothelial NF-kB, IKK, and MAP kinase by tert-butyl hydroperoxide. Free Radic. Res. 39 (2005) 399-409
43. Li N., and Karin M. Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 13012-13017
44. Li N., and Karin M. Is NF-kappaB the sensor of oxidative stress?. FASEB J. 13 (1999) 1137-1143
45. Li H., Wang J., Kaphalia B.S., Ansari G.A.S., and Khan M.F. Quantitation of acrolein-protein adducts: potential biomarker of acrolein exposure. J. Toxicol. Environ. Health, Part A 67 (2004) 513-524
46. Marshall H.E., Merchant K., and Stamler J.S. Nitrosation and oxidation in the regulation of gene expression. FASEB J. 14 (2000) 1889-1900
47. Mercurio F., Zhu H., Murray B.W., Shevchenko A., Bennett B.L., Li J., Young D.B., Barbosa M., Mann M., Manning A., and Rao A. IKK-1 and IKK-2: Cytokine- activated IkB kinases essential for NF-kB activation. Science 278 (1997) 860-866
48. Moon S.-K., Thompson L.J., Madamanchi N., Ballinger S., Papaconstantinou J., Horaist C., Runge M.S., and Patterson C. Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 280 (2001) H2779-H2788
49. Pauluhn J. Subacute inhalation toxicity of aniline in rats: analysis of time-dependence and concentration-dependence of hematotoxic and splenic effects. Toxicol. Sci. 81 (2004) 198-215
50. Pennypacker K. AP-1 transcription factors: short- and long-term modulators of gene expression in the brain. Int. Rev. Neurobiol. 42 (1998) 169-197
51. Pestka J.J., Zhou H.R., Moon Y., and Chung Y.J. Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox. Toxicol. Lett. 153 (2004) 61-73
52. Postlethwaite A.E., and Seyer J.M. Stimulation of fibroblast chemotaxis by human recombinant tumor necrosis factor alpha (TNF-alpha) and a synthetic TNF-alpha 31-68 peptide. J. Exp. Med. 172 (1990) 1749-1756
53. Rajeevan M.S., Ranamukhararachchi D.G., Vernon S.D., and Unger E.R. Use of real-time quantitative PCR to validate the results of cDNA array and differential display PCR technologies. Methods 25 (2001) 443-4451
54. Rodriguez-Porcel M., Lerman L.O., Holmes Jr. D.R., Richardson D., Napoli C., and Lerman A. Chronic antioxidant supplementation attenuates nuclear factor-kB activation and preserves endothelial function in hypercholesterolemic pigs. Cardiovas. Res. 53 (2002) 1010-1018
55. Sakurai H., Suzuki S., Kawasaki N., Nakano H., Okazaki T., Chino A., Doi T., and Saiki I. Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J. Biol. Chem. 278 (2003) 36916-36923
56. Schwenger P., Alpert D., Skolnik E.Y., and Vilcek J. Activation of p38 mitogen- activated protein kinase by sodium salicylate leads to inhibition of tumor necrosis factor-induced IkB-α phosphorylation and degradation. Mol. Cell. Biol. 18 (1998) 78-84
57. Shi M.M., Chong I., Godleski J.J., and Paulauskis J.D. Regulation of macrophage inflammatory protein-2 gene expression by oxidative stress in rat alveolar macrophages. Immunology 97 (1999) 309-315
58. Simpson D.A., Feeney S., Boyle C., and Stitt A.W. Retinal VEGF mRNA measured by SYBR green I fluorescence: a versatile approach to quantitative PCR. Mol. Vision 6 (2000) 178-183
59. Sunters A., Thomas D.P., Yeudall W.A., and Grigoriadis A.E. Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene: Induction of cyclin A and enhanced CDK2 activity. J. Biol. Chem. 279 (2004) 9882-9891
60. Takahashi S., Pearse A.D., and Marks R. Expression of c-fos proto-oncogene mRNA in non-melanoma skin cancer. J. Dermatol. Sci. 71 (1994) 54-62
61. Tessari G., Ferrara C., Poletti A., Dubrovich A., Corsini A., Del Favero G., and Naccarato R. The expression of proto-oncogene c-jun in human pancreatic cancer. Anticancer Res. 19 (1999) 863-867
62. Utsugi M., Dobashi K., Ishizuka T., Kawata T., Hisada T., shimizu Y., Ono A., and Mori M. Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-kappaB p65 trans activation plays a novel role. J. Immunol. 177 (2006) 4550-4557
63. Vermeulen L., De Wilde G., Van Damme P., Vanden Berghe W., and Haegernan G. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 22 (2003) 1313-1324
64. Wang J., Kannan S., Li H., and Khan M.F. Cytokine gene expression and activation of NF-kappa B in aniline-induced splenic toxicity. Toxicol. Appl. Pharmacol. 15 (2005) 36-44
65. Wang D., Westerheide S.D., Hanson J.L., and Baldwin Jr. A.S. Tumor necrosis factor alpha-induced phophorylation of RelA/p65 on Ser529 is controlled by casein kinase II. J. Biol. Chem. 275 (2000) 32592-32597
66. Weinberger M.A., Albert R.H., and Montgomery S.B. Splenotoxicity associated with splenic sarcomas in rats fed high doses of DRC Red No. 9 or aniline hydrochloride. J. Natl. Cancer Inst. 75 (1985) 681-690
67. Wu X., Kannan S., Ramanujam V.M.S., and Khan M.F. Iron release and oxidative DNA damage in splenic toxicity of aniline. J. Toxicol. Environ. Health, Part A 68 (2005) 657-666
68. Yan J., and Hales B.F. Activator protein-1 (AP-1) DNA binding activity is induced by hydroxyurea in organogenesis stage mouse embryos. Toxicol. Sci. 85 (2005) 1013-1023
69. Zhang L., Cheng J., Ma Y., Thomas W., Zhang J., and Du J. Dual pathways for nuclear factor kB activation by angiotensin II in vascular smooth muscle: Phosphorylation of p65 by IkB kinase and ribosomal kinase. Circ. Res. 97 (2005) 975-982
70. Zhao Q., and Lee F.S. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kB through IkB kinase-alpha and IkB kinase-β. J. Biol.Chem. 274 (1999) 8355-8358
71. Zhong H., May M.J., Jimi E., and Ghosh S. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol. Cell. 9 (2002) 625-636