Iron release and oxidative DNA damage in splenic toxicity of aniline

Journal of Toxicology and Environmental Health - Part A

Volumn 68, Issue 8, 2005, Pages 657-666

  Wu, Xiaohong ^a   Kannan, Subburaj ^a   Ramanujam, V M Sadagopa ^a   Khan, M Firoze ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANILINE; IRON; IRON CHELATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; DNA DAMAGE; IRON KINETICS; LIPID PEROXIDATION; MALE; MUTAGENICITY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SPLEEN;

ANILINE COMPOUNDS; ANIMALS; CARCINOGENS; DEOXYGUANOSINE; DNA DAMAGE; IRON; MALE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN;

EID: 17444398085     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287390590921757     Document Type: Article

References (38)

1. Abalea, V., Cillard, J., Dubos, M.-P., Anger, J.-P., Cillard, P., and Morel, I. 1998. Iron-induced oxidative DNA damage and its repair in primary rat hepatocyte culture. Carcinogenesis 19:1053-1059.
2. Abu-Qare, A. W., and Abou-Donia, M. B. 2001. Biomarkers of apoptosis: Release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2′-deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene. J. Toxicol. Environ. Health B 4:313-332.
3. Alcock, N. W. 1987. A hydrogen peroxide digestion system for tissue trace metal analysis. Biol. Trace Elem. Res. 13:363-370.
4. Altman, S. A., Zastawny, T. H., Randers, L., Cacciuttolo, M. A., Akman, S. A., Dizdaroglu, M., and Rao, G. 1995. Formation of DNA-protein cross-links in cultured mammalian cells upon treatment with iron ions. Free Radical Biol. Med. 19:897-902.
5. Aruoma, O. I., Halliwell, B., Gajewski, E., and Dizdaroglu, M. 1989. Damage to the bases in DNA induced by hydrogen peroxide and ferric ion chelates. J. Biol. Chem. 264:20509-20512.
6. Bradbear, R. A., Bain, C., Siskind, V., Schofield, F. D., Webb, S., Azelsen, E. M., Halliday, J. W., Bassett, M. L., and Powell, L. W. 1985. Cohort study of internal malignancy in genetic hemochromatosis and other chronic non-alcoholic liver diseases. J. Natl. Cancer Inst. 75:81-84.
7. Bus, J. S., and Popp, J. A. 1987. Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally-related compounds. Food Chem. Toxicol. 25:619-626.
8. Ceccarelli, D., Gallesi, D., Giovannini, F., Ferrali, M., and Masini, A. 1995. Relationship between free iron level and rat liver mitochondrial dysfunction in experimental dietary iron overload. Biochem. Biophys. Res. Commun. 209:53-59.
9. Cooke, M. S., Evans, M. D., Dizdaroglu, M., and Lunec, J. 2003. Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J. 17:1195-1214.
10. Crichton, R. R., and Charloteaux-Wauters, M. 1987. Iron transport and storage. Eur. J. Biochem. 164:485-506.
11. Dizdaroglu, M., Jaruga, P., Birincioglu, M., and Rodriguez, H. 2002. Free radical-induced damage to DNA: Mechanisms and measurement. Free Radical Biol. Med. 32:1102-1115.
12. Ferrali, M., Signorini, C., Sugherini, L., Pompella, A., Lodovici, M., Caciotti, B., Ciccolit, L., and Comporti, M. 1997. Release of free, redox-active iron in the liver and DNA oxidative damage following phenylhydrazine intoxication. Biochem. Pharmacol. 53:1743-1751.
13. Goodman, D. G., Ward, J. M., and Reichardt, W. D. 1984. Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4′- sulfonylydianiline, or D&C red no. 9. J. Natl. Cancer Inst. 73:265-273.
14. Hartwig, A., and Schlepegrell, R. 1995. Induction of oxidative DNA damage by ferric iron in mammalian cells. Carcinogenesis 16:3009-3013.
15. Hartwig, A., Klyszcz-Nasko, H., Schlepegrell, R., and Beyersmann, D. 1993. Cellular damage by ferric nitrilotriacetate and ferric citrate in V79 cells: Interrelationship between lipid peroxidation, DNA strand breaks and sister-chromatid exchanges. Carcinogenesis 14:107-112.
16. Halliwell, B., and Gutteridge, J. M. C. 1985. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219:1-14.
17. Jenkins, F. P., Robinson, J. A., Gellatly, J. B. M., and Salmond, G. W. A. 1972. The no-effect dose of aniline in human subjects and a comparison of aniline toxicity in man and the rat. Food Cosmet. Toxicol. 10:671-779.
18. Kang, J. O., Jones, C., and Brothwell, B. 1998. Toxicity associated with iron overload found in hemochromatosis: Possible mechanism in a rat model. Clin Lab. Sci. 11:350-354.
19. Khan, M. F., Kaphalia, B. S., Boor, P. J., and Ansari, G. A. S. 1993. Subchronic toxicity of aniline hydrochloride in rats. Arch. Environ. Contam. Toxicol. 24:368-374.
20. Khan, M. F., Boor, P. J., Kaphalia, B. S., and Ansari, G. A. S. 1995a. Erythrocyte-aniline interaction leads to their accumulation and iron deposition in spleen. J. Toxicol. Environ. Health 44:415-421.
21. Khan, M. F., Boor, P. J., Kaphalia, B. S., Alcock, N. W., and Ansari, G. A. S. 1995b. Hematopoietic toxicity of linoleic acid anilide: Importance of aniline. Fundam. Appl. Toxicol. 25:224-232.
22. Khan, M. F., Boor, P. J., Gu, Y., Alcock, N. W., and Ansari, G. A. S. 1997a. Oxidative stress in the splenotoxicity of aniline. Fundam, Appl. Toxicol. 35:22-30.
23. Khan, M. F., Wu, X., Kaphalia, B. S., Boor, P. J., and Ansari, G. A. S. 1997b. Acute hematopoietic toxicity of aniline. Toxicol. Lett. 92:31-37.
24. Khan, M. F., Wu, X., Boor, P. J., and Ansari, G. A. S. 1999a. Oxidative modification of lipids and proteins in aniline-induced splenic toxicity. Toxicol. Sci. 48:134-140.
25. Khan, M. F., Wu, X., Alcock, N. W., Boor, P. J., and Ansari, G. A. S. 1999b. Iron exacerbates aniline-associated splenio toxicity. J. Toxicol. Environ. Health A 57:173-184.
26. Khan, M. F., Wu, X., Ansari, G. A. S., and Boor, P. J. 2003a. Malondialdehyde-protein adducts in the spleens of aniline-treated rats: Immunohistochemical detection and localization. J. Toxicol. Environ. Health A 66:93-102.
27. Khan, M. F., Wu, X., and Wang, J. 2003b. Up-regulation of transforming growth factor-β1 in the spleen of aniline-treated rats. Toxicol. Appl. Pharmacol. 187:22-28.
28. Khan, M. F., Wu, X., Kaphalia, B. S., Boor, P. J., and Ansari, G. A. S. 2003c. Nitrotyrosine formation in splenic toxicity of aniline. Toxicology 194:95-102.
29. Kuchino, Y., Mori, F., Kasai, H., Inoue, H., Iwai, S., Miura, K., Otsuka, E., and Nishimura, S. 1987. Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and adjacent residues. Nature 327:77-79.
30. Lodovici, M., Casalini, C., Briani, C., and Dolara, P. 1997. Oxidative liver DNA damage in rats treated with pesticide mixtures. Toxicology 117:55-60.
31. McBride, T. J., Preston, B. D., and Loeb, L. A. 1991. Mutagenic spectrum resulting from DNA damage by oxygen radicals. Biochemistry 30:207-213.
32. Morel, I., Hamon-Bouer, C., Abalea, V., Cillard, P., and Cillard, J. 1997. Comparison of oxidative damage of DNA and lipids in normal and tumor rat hepatocyte cultures treated with ferric nitrilotriacetate. Cancer Lett. 119:31-36.
33. Reif, D. W., Beales, I. L. P., Thomas, C. E., and Aust, S. D. 1988. Effect of diquat on the distribution of iron in rat liver. Toxicol. Appl. Pharmacol. 93:506-510.
34. Toyokuni, S. 1996. Iron-induced carcinogenesis: the role of redox regulation. Free Radical Biol. Med. 20:553-566.
35. Toyokuni, S., Mori, T., and Dizdaroglu, M. 1994. DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate. Int. J. Cancer 57:123-128.
36. Tsai, K., Hsu, T.-G., Hsu, K.-M., Cheng, H., Liu, T.-Y., Hsu, C-F., and Kong, C.-W. 2001. Oxidative DNA damage in human peripheral leukocytes induced by massive aerobic exercise. Free Radical Biol. Med. 31:1465-1472.
37. Wang, J., Kannan, S., Li, H., and Khan, M. F. 2005. Cytokine gene expression and activation of NF-κB in aniline-induced splenic toxicity. Toxicol. Appl. Pharmacol. 203:36-44.
38. Weinberger, M. A., Albert, R. H., and Montgomery, S. B. 1985. Splenotoxicity associated with splenic sarcomas in rats fed high doses of D&C red no. 9 or aniline hydrochloride. J. Natl. Cancer Inst. 75:681-690.