Up-regulation of transforming growth factor-β1 in the spleen of aniline-treated rats

Toxicology and Applied Pharmacology

Volumn 187, Issue 1, 2003, Pages 22-28

  Khan, M Firoze ^a   Wu, Xiaohong ^a   Wang, Jianling ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Aniline; Lipid peroxidation; Malondialdehyde protein adducts; mRNA; Splenic toxicity; TGF 1

Indexed keywords

ANILINE; MALONALDEHYDE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL POPULATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SPLEEN; SPLEEN CELL; SPLEEN WEIGHT; SUPERNATANT; TOXICITY; UPREGULATION; WESTERN BLOTTING;

EID: 0037440922     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(02)00041-8     Document Type: Article

References (30)

1. 2 (I) collagen gene activity by JNK in hepatic stellate cells. Free Radical Biol. Med. 30:2001;846-857.
2. Bus J.S., Popp J.A. Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally-related compounds. Food Chem. Toxicol. 25:1987;619-626.
3. Chojkier M., Houglum K., Solis-Herruzo J., Brenner D.A. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts a role for lipid peroxidation? J. Biol. Chem. 264:1989;16957-16962.
4. Goodman D.G., Ward J.M., Reichardt W.D. Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4′-sulfonyldianiline, or D&C Red No. 9. J. Natl. Cancer Inst. 73:1984;265-273.
5. Houglum K., Ramm G.A., Crawford D.H.G., Witztum J.L., Powell L.W., Chojkier M. Excess iron induces hepatic oxidative stress and transforming growth factor β1 in genetic hemochromatosis. Hepatology. 26:1997;605-610.
6. Hoyt D.G., Lazo J.S. Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-β precede bleomycin-induced pulmonary fibrosis in mice. J. Pharmacol. Exp. Ther. 246:1988;765-771.
7. Khan M.F., Boor P.J., Kaphalia B.S., Alcock N.W., Ansari G.A.S. Hematopoietic toxicity of linoleic acid anilide importance of aniline . Fundam. Appl. Toxicol. 25:1995;224-232.
8. Khan M.F., Gu Y., Alcock N.W., Boor P.J., Ansari G.A.S. Oxidative stress in splenotoxicity of aniline. Fundam. Appl. Toxicol. 35:1997;22-30.
9. Khan M.F., Kaphalia B.S., Boor P.J., Ansari G.A.S. Subchronic toxicity of aniline hydrochloride in rats. Arch. Environ. Contam. Toxicol. 24:1993;368-374.
10. Khan M.F., Wu X., Alcock N.W., Boor P.J., Ansari G.A.S. Iron exacerbates aniline-associated splenic toxicity. J. Toxicol. Environ. Health Part A. 57:1999;173-184.
11. Khan M.F., Wu X., Ansari G.A.S., Boor P.J. Malondialdehyde-protein adducts in the spleens of aniline-treated rats immunohistochemical detection and localization . J. Toxicol. Environ. Health Part A. 66:2003;93-102.
12. Khan M.F., Wu X., Boor P.J., Ansari G.A.S. Oxidative modification of proteins and lipids in aniline-induced splenic toxicity. Toxicol. Sci. 48:1999;134-140.
13. Khan M.F., Wu X., Kaphalia B.S., Boor P.J., Ansari G.A.S. Acute hematopoietic toxicity of aniline in rats. Toxicol. Lett. 92:1997;31-37.
14. Kovacs E.J. Fibrogenic cytokines the role of imune mediators in the development of scar tissue . Immunol. Today. 12:1991;17-23.
15. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
16. Leonarduzzi G., Scavazza A., Biasi F., Chiarpotto E., Camandola S., Vogel S., Dargel R., Poli G. The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 in the macrophage lineage a link between oxidative injury and fibrosclerosis . FASEB J. 11:1997;851-857.
17. Paradis V., Mathurin P., Kollinger M., Imbert-Bismut F., Charlotte F., Piton A., Opolon P., Holstege A., Poynard T., Bedossa P. In situ detection of lipid peroxidation in chronic hepatitis C correlation with pathological features . J. Clin. Pathol. 50:1997;401-406.
18. Parola M., Leonarduzzi G., Robino G., Albano E., Poli G., Dianzani M.U. On the role of lipid peroxidation in the pathogenesis of liver damage induced by long-standing cholestasis. Free Radical Biol. Med. 20:1996;351-359.
19. Parola M., Robino G. Oxidative stress-related molecules and liver fibrosis. J. Hepatol. 35:2001;297-306.
20. Pietrangelo A., Gualdi R., Casalgrandi G., Montosi G., Ventura E. Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents. J. Clin. Invest. 95:1995;1824-1831.
21. Pietrangelo A., Montosi G., Garuti C., Contri M., Giovannini F., Ceccarelli D., Masini A. Iron-induced oxidant stress in nonparenchymal liver cells mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybin . J. Bioenerg. Biomembr. 34:2002;67-79.
22. Poli G., Parola M. Oxidative damage and fibrogenesis. Free Radical Biol. Med. 22:1997;287-305.
23. Reinhart P.G., Gairola C.G. Amiodarone-induced pulmonary toxicity in Fischer rats release of tumor necrosis factor alpha and transforming growth factor beta by pulmonary alveolar macrophages . J. Toxicol. Environ. Health. 52:1997;353-365.
24. Ross R. Atherosclerosis a defense mechanism gone awry . Am. J. Pathol. 143:1993;987-1002.
25. Sime P.J., O'Reilly M.A. Fibrosis of the lung and other tissues new concepts in pathogenesis and treatment . Clin. Immunol. 99:2001;308-319.
26. Towbin H., Stachelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets procedure and some applications . Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
27. Tsukamoto H. Cytokine regulation of hepatic stellate cells in liver fibrosis. Alcohol Clin. Exp. Res. 23:1999;911-916.
28. Ward J.M., Reznik G., Garner F.M. Proliferative lesions of the spleen in male F344 rats fed diets containing p-chloroaniline. Vet. Pathol. 17:1980;200-205.
29. Weinberger M.A., Albert R.H., Montgomery S.B. Splenotoxicity associated with splenic sarcomas in rats fed high doses of D&C Red No. 9 or aniline hydrochloride. J. Natl. Cancer Inst. 75:1985;681-690.
30. Zheng X.Y., Zhang J.Z., Tu P., Ma S.Q. Expression of platelet-derived growth factor B-chain and platelet-derived growth factor beta-receptor in fibroblasts of scleroderma. J. Dermatol. Sci. 18:1998;90-97.