H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding

Analytical Chemistry

Volumn 79, Issue 15, 2007, Pages 5869-5877

  Tang, Liangjie ^a   Hopper, Erin D ^a   Tong, Yan ^a,c   Sadowsky, Jack D ^b   Peterson, Kimberly J ^b   Gellman, Samuel H ^b   Fitzgerald, Michael C ^a  

^a DUKE UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c MCKINSEY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISSOCIATION CONSTANTS; MULTIDOMAIN PROTEINS; SUPREX ANALYSES; UNFOLDING PROPERTIES;

BINDING ENERGY; DATA ACQUISITION; DENATURATION; FREE ENERGY; LIGANDS; MASS SPECTROMETRY;

PROTEINS;

CALMODULIN; CARBONATE DEHYDRATASE II; PROTEIN; PROTEIN BCL XL; PROTEIN RMLB; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; DISSOCIATION CONSTANT; EVALUATION; LIGAND BINDING; MASS SPECTROMETRY; MEASUREMENT; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; THERMODYNAMICS;

BCL-X PROTEIN; CALMODULIN; CARBONIC ANHYDRASE II; DEUTERIUM EXCHANGE MEASUREMENT; HYDRO-LYASES; KINETICS; LIGANDS; MASS SPECTROMETRY; MOLECULAR WEIGHT; PROTEIN BINDING; PROTEIN DENATURATION; PROTEINS; THERMODYNAMICS;

EID: 34547813543     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac0700777     Document Type: Article

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