Loss of sugar detection by GLUT2 affects glucose homeostasis in mice

PLoS ONE

Volumn 2, Issue 12, 2007, Pages

  Stolarczyk, Emilie ^a,b,c   Le Gall, Maude ^a,b,c   Even, Patrick ^d   Houllier, Anne ^a,b,c   Serradas, Patricia ^a,b,c   Brot Laroche, Edith ^a,b,c   Leturque, Armelle ^a,b,c  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSERM   (France)

^d INRA Institut National de la Recherche Agronomique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCORECEPTOR; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; SLC2A2 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSURIA; IN VITRO STUDY; INSULIN SYNTHESIS; KIDNEY TUBULE ABSORPTION; LIPID PEROXIDATION; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PROTEIN FUNCTION; PROTEIN TARGETING; STARVATION; STREPTOZOCIN DIABETES; ANIMAL; GENETICS; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; LIPID METABOLISM; METABOLISM; OXIDATION REDUCTION REACTION; PANCREAS; PHYSIOLOGY; TRANSGENIC MOUSE;

MAMMALIA; MUS; MUS MUSCULUS;

ANIMALS; GLUCOSE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORTER TYPE 2; HOMEOSTASIS; LIPID METABOLISM; MICE; MICE, TRANSGENIC; OXIDATION-REDUCTION; PANCREAS;

EID: 44949159916     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001288     Document Type: Article

References (56)

1. Matschinsky FM (1996) Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45: 223-241.
2. Matschinsky FM, Glaser B, Magnuson MA (1998) Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities. Diabetes 47: 307-315.
3. Schuit F, Flamez D, De Vos A, Pipeleers D (2002) Glucose-regulated gene expression maintaining the glucose-responsive state of beta-cells. Diabetes 51 Suppl 3: S326-332.
4. Girard J, Ferre P, Foufelle F (1997) Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes. Annu Rev Nutr 17: 325-352.
5. Vaulont S, Vasseur-Cognet M, Kahn A (2000) Glucose regulation of gene transcription. J Biol Chem 275: 31555-31558.
6. Towle HC (2005) Glucose as a regulator of eukaryotic gene transcription. Trends Endocrinol Metab 16: 489-494.
7. Ozcan S, Dover J, Rosenwald AG, Wolfl S, Johnston M (1996) Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc Natl Acad Sci U S A 93: 12428-12432.
8. Holsbeeks I, Lagatie O, Van Nuland A, Van de Velde S, Thevelein JM (2004) The eukaryotic plasma membrane as a nutrient-sensing device. Trends Biochem Sci 29: 556-564.
9. Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Burke TR Jr, et al. (2000) Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. J Biol Chem 275: 40817-40826.
10. Guillam MT, Hümmler E, Schaerer E, Yeh JI, Birnbaum MJ, et al. (1997) Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet 17: 327-330.
11. Santer R, Schneppenheim R, Suter D, Schaub J, Steinmann B (1998) Fanconi-Bickel syndrome-the original patient and his natural history, historical steps leading to the primary defect, and a review of the literature. Eur J Pediatr 157: 783-797.
12. Guillemain G, Loizeau M, Pinçon-Raymond M, Girard J, Leturque A (2000) The large intracytoplasmic loop of the glucose transporter GLUT2 is involved in glucose signaling in hepatic cells. J Cell Sci 113 (Pt 5): 841-847.
13. Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, et al. (2003) A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A 100: 11753-11758.
14. Bady I, Marty N, Dallaporta M, Emery M, Gyger J, et al. (2006) Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding. Diabetes 55: 988-995.
15. Guillam MT, Dupraz P, Thorens B (2000) Glucose uptake, utilization, and signaling in GLUT2-null islets. Diabetes 49: 1485-1491.
16. Marty N, Bady I, Thorens B (2006) Distinct Classes of Central GLUT2- Dependent Sensors Control Counterregulation and Feeding. Diabetes 55 Suppl 2: S108-113.
17. Meugnier E, Faraj M, Rome S, Beauregard G, Michaut A, et al. (2007) Acute hyperglycemia induces a global down-regulation of gene expression in adipose tissue and in skeletal muscle of healthy subjects. Diabetes.
18. Yvan-Charvet L, Even P, Bloch-Faure M, Guerre-Millo M, Moustaid-Moussa N, et al. (2005) Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance. Diabetes 54: 991-999.
19. Teegarden D (2005) The influence of dairy product consumption on body composition. J Nutr 135: 2749-2752.
20. Szkudelski T (2001) The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 50: 537-546.
21. Wang H, Kouri G, Wollheim CB (2005) ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity. J Cell Sci 118: 3905-3915.
22. Giddings SJ, Chirgwin J, Permutt MA (1981) The effects of fasting and feeding on preproinsulin messenger RNA in rats. J Clin Invest 67: 952-960.
23. Itoh N, Okamoto H (1980) Translational control of proinsulin synthesis by glucose. Nature 283: 100-102.
24. Schuit FC, In't Veld PA, Pipeleers DG (1988) Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc Natl Acad Sci U S A 85: 3865-3869.
25. Skelly RH, Schuppin GT, Ishihara H, Oka Y, Rhodes CJ (1996) Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line. Diabetes 45: 37-43.
26. Wicksteed B, Alarcon C, Briaud I, Lingohr MK, Rhodes CJ (2003) Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem 278: 42080-42090.
27. Nielsen DA, Welsh M, Casadaban MJ, Steiner DF (1985) Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA. J Biol Chem 260: 13585-13589.
28. Welsh M, Nielsen DA, MacKrell AJ, Steiner DF (1985) Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability. J Biol Chem 260: 13590-13594.
29. Chick WL (1973) Beta cell replication in rat pancreatic monolayer cultures. Effects of glucose, tolbutamide, glucocorticoid, growth hormone and glucagon. Diabetes 22: 687-693.
30. Bonner-Weir S, Deery D, Leahy JL, Weir GC (1989) Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes 38: 49-53.
31. Bernard C, Thibault C, Berthault MF, Magnan C, Saulnier C, et al. (1998) Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement. Diabetes 47: 1058-1065.
32. Päth G, Opel A, Gehlen M, Rothhammer V, Niu X, et al. (2006) Glucose-dependent expansion of pancreatic beta-cells by the protein p8 in vitro and in vivo. Am J Physiol Endocrinol Metab 291: E1168-1176.
33. Hoorens A, Van de Casteele M, Kloppel G, Pipeleers D (1996) Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98: 1568-1574.
34. Bernard C, Berthault MF, Saulnier C, Ktorza A (1999) Neogenesis vs. apoptosis a main components of pancreatic beta cell mass changes in glucose-infused normal and mildly diabetic adult rats. Faseb J 13: 1195-1205.
35. Poitout V, Briaud I, Kelpe C, Hagman D (2004) Gluco-lipotoxicity of the pancreatic beta cell. Ann Endocrinol (Paris) 65: 37-41.
36. Robertson RP, Harmon J, Tran PO, Poitout V (2004) Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53 Suppl 1: S119-124.
37. Kaiser N, Leibowitz G, Nesher R (2003) Glucotoxicity and beta-cell failure in type 2 diabetes mellitus. J Pediatr Endocrinol Metab 16: 5-22.
38. Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, et al. (2004) Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 286: E41-49.
39. Dai C, Huh CG, Thorgeirsson SS, Liu Y (2005) Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am J Pathol 167: 429-436.
40. Heit JJ, Karnik SK, Kim SK (2006) Intrinsic regulators of pancreatic beta-cell proliferation. Annu Rev Cell Dev Biol 22: 311-338.
41. Izzedine H, Launay-Vacher V, Isnard-Bagnis C, Deray G (2003) Drug-induced Fanconi's syndrome. Am J Kidney Dis 41: 292-309.
42. Berry GT, Baynes JW, Wells-Knecht KJ, Szwergold BS, Santer R (2005) Elements of diabetic nephropathy in a patient with GLUT 2 deficiency. Mol Genet Metab 86: 473-477.
43. Wright EM, Hirayama BA, Loo DF (2007) Active sugar transport in health and disease. J Intern Med 261: 32-43.
44. Menzel R, Kaisaki PJ, Rjasanowski I, Heinke P, Kerner W, et al. (1998) A low renal threshold for glucose in diabetic patients with a mutation in the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene. Diabet Med 15: 816-820.
45. Pontoglio M, Prie D, Cheret C, Doyen A, Leroy C, et al. (2000) HNF1alpha controls renal glucose reabsorption in mouse and man. EMBO Rep 1: 359-365.
46. Niwa H, Yamamura K, Miyazaki J (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108: 193-199.
47. Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, et al. (2004) Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem 279: 20314-20326.
48. Quinet EM, Savio DA, Halpern AR, Chen L, Miller CP, et al. (2004) Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor. J Lipid Res 45: 1929-1942.
49. Guillemain G, Muñoz-Alonso MJ, Cassany A, Loizeau M, Faussat AM, et al. (2002) Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells. Biochem J 364: 201-209.
50. Vouret-Craviari V, Van Obberghen-Schilling E, Scimeca JC, Van Obberghen E, Pouyssegur J (1993) Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist. Biochem J 289 (Pt 1): 209-214.
51. Hull RL, Kodama K, Utzschneider KM, Carr DB, Prigeon RL, et al. (2005) Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation. Diabetologia 48: 1350-1358.
52. Gouyon F, Caillaud L, Carriere V, Klein C, Dalet V, et al. (2003) Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice. J Physiol 552: 823-832.
53. Even PC, Mokhtarian A, Pele A (1994) Practical aspects of indirect calorimetry in laboratory animals. Neurosci Biobehav Rev 18: 435-447.
54. Even PC, Perrier E, Aucouturier JL, Nicolaïdis S (1991) Utilisation of the method of Kalman filtering for performing the on-line computation of background metabolism in the free-moving, free-feeding rat. Physiol Behav 49: 177-187.
55. Even PC, Bertin E, Gangnerau MN, Roseau S, Tome D, et al. (2003) Energy restriction with protein restriction increases basal metabolism and meal-induced thermogenesis in rats. Am J Physiol Regul Integr Comp Physiol 284: R751-759.
56. Jouannot E, Duong-Van-Huyen JP, Bourahla K, Laugier P, Lelievre-Pegorier M, et al. (2006) High-frequency ultrasound detection and follow-up of Wilms' tumor in the mouse. Ultrasound Med Biol 32: 183-190.