Structural basis of substrate recognition in thiopurine S-methyltransferase

Biochemistry

Volumn 47, Issue 23, 2008, Pages 6216-6225

  Peng, Yi ^a   Feng, Qiping ^b   Wilk, Dennis ^a   Adjei, Araba A ^b,c   Salavaggione, Oreste E ^b,c   Weinshilboum, Richard M ^b   Yee, Vivien C ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; CHEMOTHERAPY; DRUG DELIVERY; DRUG DOSAGE; DRUG THERAPY; ENZYME ACTIVITY; FOOD ADDITIVES; SELF ASSEMBLY;

6-MERCAPTOPURINE (6MP); ACTIVE SITES; ALLOZYMES; BINARY COMPLEXES; CYTOTOXIC EFFECTS; HOMOCYSTEINE (HCY); METHYLTRANSFERASE (MTASE); PRODRUGS; S-ADENOSYL-L-METHIONINE (SAM); STRUCTURAL BASIS; SUBSTRATE RECOGNITION; TERNARY COMPLEXES;

ENZYMES;

AMINO ACID; ARGININE; ENZYME; GLUTAMIC ACID; HISTIDINE; MERCAPTOPURINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; TERNARY COMPLEX FACTOR; THIOPURINE METHYLTRANSFERASE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; LIGAND BINDING; PRIORITY JOURNAL; REACTION ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; METHYLTRANSFERASES; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION; RESTRICTION MAPPING; SUBSTRATE SPECIFICITY; VARIATION (GENETICS);

MURINAE;

EID: 44949153646     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800102x     Document Type: Article

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