메뉴 건너뛰기




Volumn 15, Issue 4, 2008, Pages 509-517

Combination of simvastatin administration and EPC transplantation enhances angiogenesis and protects against apoptosis for hindlimb ischemia

Author keywords

Angiogenesis; Apoptosis; Endothelial progenitor cells; Peripheral arterial disease; Simvastatin

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SIMVASTATIN;

EID: 44949131802     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/s11373-008-9243-1     Document Type: Article
Times cited : (26)

References (51)
  • 1
    • 34249914794 scopus 로고    scopus 로고
    • Statins and peripheral arterial disease: Effects on claudication, disease progression, and prevention of cardiovascular events
    • Coppola G, Novo S (2007) Statins and peripheral arterial disease: effects on claudication, disease progression, and prevention of cardiovascular events. Arch Med Res 38:479-488
    • (2007) Arch Med Res , vol.38 , pp. 479-488
    • Coppola, G.1    Novo, S.2
  • 2
    • 0345688062 scopus 로고    scopus 로고
    • Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells
    • Urbich C, Heeschen C, Aicher A, Dernbach E, Zeiher AM, Dimmeler S (2003) Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation 108:2511-2516
    • (2003) Circulation , vol.108 , pp. 2511-2516
    • Urbich, C.1    Heeschen, C.2    Aicher, A.3    Dernbach, E.4    Zeiher, A.M.5    Dimmeler, S.6
  • 3
    • 0034724335 scopus 로고    scopus 로고
    • Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization
    • Kalka C, Masuda H, Takahashi T et al (2000) Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA 97:3422-3427
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3422-3427
    • Kalka, C.1    Masuda, H.2    Takahashi Et Al, T.3
  • 4
    • 0034129573 scopus 로고    scopus 로고
    • Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization
    • Murohara T, Ikeda H, Duan J et al (2000) Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization. J Clin Invest 105:1527-1536
    • (2000) J Clin Invest , vol.105 , pp. 1527-1536
    • Murohara, T.1    Ikeda, H.2    Duan, J.3
  • 5
    • 0034898468 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells
    • Llevadot J, Murasawa S, Kureishi Y et al (2001) HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells. J Clin Invest 108:399-405
    • (2001) J Clin Invest , vol.108 , pp. 399-405
    • Llevadot, J.1    Murasawa, S.2    Kureishi, Y.3
  • 6
    • 0034908652 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
    • Dimmeler S, Aicher A, Vasa M et al (2001) HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest 108:391-397
    • (2001) J Clin Invest , vol.108 , pp. 391-397
    • Dimmeler, S.1    Aicher, A.2    Vasa, M.3
  • 7
    • 0037173080 scopus 로고    scopus 로고
    • Statin therapy accelerates reendothelialization: A novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells
    • Walter DH, Rittig K, Bahlmann FH et al (2002) Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation. 105:3017-3024
    • (2002) Circulation. , vol.105 , pp. 3017-3024
    • Walter, D.H.1    Rittig, K.2    Bahlmann, F.H.3
  • 8
    • 0041733082 scopus 로고    scopus 로고
    • Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury
    • Werner N, Junk S, Laufs U et al (2003) Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury. Circ Res 93:e17-e24
    • (2003) Circ Res , vol.93
    • Werner, N.1    Junk, S.2    Laufs, U.3
  • 9
    • 0038814315 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes
    • Assmus B, Urbich C, Aicher A et al (2003) HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes. Circ Res 92:1049-1055
    • (2003) Circ Res , vol.92 , pp. 1049-1055
    • Assmus, B.1    Urbich, C.2    Aicher, A.3
  • 10
    • 0033971901 scopus 로고    scopus 로고
    • Bcl-2 family: Life-or-death switch
    • Tsujimoto Y, Shimizu S (2000) Bcl-2 family: life-or-death switch. FEBS Lett 466:6-10
    • (2000) FEBS Lett , vol.466 , pp. 6-10
    • Tsujimoto, Y.1    Shimizu, S.2
  • 11
    • 0345303680 scopus 로고    scopus 로고
    • Balanced expression of mitochondrial apoptosis regulatory proteins correlates with long-term survival of cardiac allografts
    • Tung TC, Cui G, Oshima K, Laks H, Sen L (2003) Balanced expression of mitochondrial apoptosis regulatory proteins correlates with long-term survival of cardiac allografts. Am J Physiol Heart Circ Physiol 285:H2832-H2841
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Tung, T.C.1    Cui, G.2    Oshima, K.3    Laks, H.4    Sen, L.5
  • 12
    • 0035912855 scopus 로고    scopus 로고
    • Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease
    • Vasa M, Fichtlscherer S, Adler K et al (2001) Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 103:2885-2890
    • (2001) Circulation , vol.103 , pp. 2885-2890
    • Vasa, M.1    Fichtlscherer, S.2    Adler, K.3
  • 13
    • 17644433975 scopus 로고    scopus 로고
    • Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease
    • Vasa M, Fichtlscherer S, Aicher A et al (2001) Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 89:E1-E7
    • (2001) Circ Res , vol.89
    • Vasa, M.1    Fichtlscherer, S.2    Aicher, A.3
  • 14
    • 0032102292 scopus 로고    scopus 로고
    • Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
    • Murohara T, Asahara T, Silver M et al (1998) Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest 101:2567-2578
    • (1998) J Clin Invest , vol.101 , pp. 2567-2578
    • Murohara, T.1    Asahara, T.2    Silver, M.3
  • 15
    • 0035852662 scopus 로고    scopus 로고
    • Augmentation of postnatal neovascularization with autologous bone marrow transplantation
    • Shintani S, Murohara T, Ikeda H et al (2001) Augmentation of postnatal neovascularization with autologous bone marrow transplantation. Circulation 103:897-903
    • (2001) Circulation , vol.103 , pp. 897-903
    • Shintani, S.1    Murohara, T.2    Ikeda, H.3
  • 16
    • 35348875336 scopus 로고    scopus 로고
    • The similar effect of transplantation of marrow-derived mesenchymal stem cells with or without prior differentiation induction in experimental myocardial infarction
    • Nassiri SM, Khaki Z, Soleimani M et al (2007) The similar effect of transplantation of marrow-derived mesenchymal stem cells with or without prior differentiation induction in experimental myocardial infarction. J Biomed Sci 14:745-755
    • (2007) J Biomed Sci , vol.14 , pp. 745-755
    • Nassiri, S.M.1    Khaki, Z.2    Soleimani, M.3
  • 17
    • 33745066152 scopus 로고    scopus 로고
    • Intravenous transplantation of mesenchymal stem cells improves cardiac performance after acute myocardial ischemia in female rats
    • Jiang W, Ma A, Wang T et al (2006) Intravenous transplantation of mesenchymal stem cells improves cardiac performance after acute myocardial ischemia in female rats. Transpl Int 19:570-580
    • (2006) Transpl Int , vol.19 , pp. 570-580
    • Jiang, W.1    Ma, A.2    Wang, T.3
  • 18
    • 19944431981 scopus 로고    scopus 로고
    • Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia
    • Iwase T, Nagaya N, Fujii T et al (2005) Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia. Circulation 111:356-362
    • (2005) Circulation , vol.111 , pp. 356-362
    • Iwase, T.1    Nagaya, N.2    Fujii, T.3
  • 19
    • 0034644636 scopus 로고    scopus 로고
    • Laminar shear stress upregulates integrin expression: Role in endothelial cell adhesion and apoptosis
    • Urbich C, Walter DH, Zeiher AM, Dimmeler S (2000) Laminar shear stress upregulates integrin expression: role in endothelial cell adhesion and apoptosis. Circ Res 87:683-689
    • (2000) Circ Res , vol.87 , pp. 683-689
    • Urbich, C.1    Walter, D.H.2    Zeiher, A.M.3    Dimmeler, S.4
  • 20
    • 34249819383 scopus 로고    scopus 로고
    • Additive effect of endothelial progenitor cell mobilization, bone marrow mononuclear cell transplantation on angiogenesis in mouse ischemic limbs
    • Jeon O, Song SJ, Bhang SH, Choi CY, Kim MJ, Kim BS (2007) Additive effect of endothelial progenitor cell mobilization, bone marrow mononuclear cell transplantation on angiogenesis in mouse ischemic limbs. J Biomed Sci 14:323-330
    • (2007) J Biomed Sci , vol.14 , pp. 323-330
    • Jeon, O.1    Song, S.J.2    Bhang, S.H.3    Choi, C.Y.4    Kim, M.J.5    Kim, B.S.6
  • 21
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y, Luo Z, Shiojima I et al (2000) The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 6:1004-1010
    • (2000) Nat Med , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3
  • 22
    • 0035912855 scopus 로고    scopus 로고
    • Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease
    • Vasa M, Fichtlscherer S, Adler K et al (2001) Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 103:2885-2890
    • (2001) Circulation , vol.103 , pp. 2885-2890
    • Vasa, M.1    Fichtlscherer, S.2    Adler, K.3
  • 23
    • 20444497875 scopus 로고    scopus 로고
    • FOXO-dependent expression of the proapoptotic protein Bim: Pivotal role for apoptosis signaling in endothelial progenitor cells
    • Urbich C, Knau A, Fichtlscherer S et al (2005) FOXO-dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cells. FASEB J 19:974-976
    • (2005) FASEB J , vol.19 , pp. 974-976
    • Urbich, C.1    Knau, A.2    Fichtlscherer, S.3
  • 24
    • 0344865674 scopus 로고    scopus 로고
    • Profound apoptosis-mediated regional myocyte loss and compensatory hypertrophy in pigs with hibernating myocardium
    • Lim H, Fallavollita JA, Hard R, Kerr CW, Canty JM Jr (1999) Profound apoptosis-mediated regional myocyte loss and compensatory hypertrophy in pigs with hibernating myocardium. Circulation. 100:2380-2386
    • (1999) Circulation. , vol.100 , pp. 2380-2386
    • Lim, H.1    Fallavollita, J.A.2    Hard, R.3    Kerr, C.W.4    Canty Jr., J.M.5
  • 25
    • 0030249340 scopus 로고    scopus 로고
    • Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart
    • Olivetti G, Quaini F, Sala R et al (1996) Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. J Mol Cell Cardiol. 28:2005-2016
    • (1996) J Mol Cell Cardiol. , vol.28 , pp. 2005-2016
    • Olivetti, G.1    Quaini, F.2    Sala, R.3
  • 26
    • 31544450021 scopus 로고    scopus 로고
    • Mesenchymal stem cells are superior to angiogenic growth factor genes for improving myocardial performance in the mouse model of acute myocardial infarction
    • Shyu KG, Wang BW, Hung HF, Chang CC, Shih DT (2006) Mesenchymal stem cells are superior to angiogenic growth factor genes for improving myocardial performance in the mouse model of acute myocardial infarction. J Biomed Sci 13:47-58
    • (2006) J Biomed Sci , vol.13 , pp. 47-58
    • Shyu, K.G.1    Wang, B.W.2    Hung, H.F.3    Chang, C.C.4    Shih, D.T.5
  • 27
    • 9444264315 scopus 로고    scopus 로고
    • Transplantation of low dose CD34+KDR+ cells promotes vascular and muscular regeneration in ischemic limbs
    • Madeddu P, Emanueli C, Pelosi E et al (2004) Transplantation of low dose CD34+KDR+ cells promotes vascular and muscular regeneration in ischemic limbs. FASEB J 18:1737-1739
    • (2004) FASEB J , vol.18 , pp. 1737-1739
    • Madeddu, P.1    Emanueli, C.2    Pelosi, E.3
  • 28
    • 0036400353 scopus 로고    scopus 로고
    • Alterations in endothelial cell proliferation and apoptosis contribute to vascular remodeling following hind-limb ischemia in rabbits
    • Dai Q, Thompson MA, Pippen AM, Cherwek H, Taylor DA, Annex BH (2002) Alterations in endothelial cell proliferation and apoptosis contribute to vascular remodeling following hind-limb ischemia in rabbits. Vasc Med 7:87-91
    • (2002) Vasc Med , vol.7 , pp. 87-91
    • Dai, Q.1    Thompson, M.A.2    Pippen, A.M.3    Cherwek, H.4    Taylor, D.A.5    Annex, B.H.6
  • 29
    • 0035806626 scopus 로고    scopus 로고
    • PRINCE Investigators. Effect of statin therapy on C-reactive protein levels: The pravastatin inflammation/CRP evaluation (PRINCE): A randomized trial and cohort study
    • Albert MA, Danielson E, Rifai N, Ridker PM (2001) PRINCE Investigators. Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study. JAMA 286:64-70
    • (2001) JAMA , vol.286 , pp. 64-70
    • Albert, M.A.1    Danielson, E.2    Rifai, N.3    Ridker, P.M.4
  • 31
    • 1842486565 scopus 로고    scopus 로고
    • Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    • Kinnaird T, Stabile E, Burnett MS et al (2004) Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109:1543-1549
    • (2004) Circulation , vol.109 , pp. 1543-1549
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.S.3
  • 32
    • 20244389882 scopus 로고    scopus 로고
    • Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells
    • Gnecchi M, He H, Liang OD et al (2005) Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 11:367-368
    • (2005) Nat Med , vol.11 , pp. 367-368
    • Gnecchi, M.1    He, H.2    Liang, O.D.3
  • 33
    • 33745356932 scopus 로고    scopus 로고
    • Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling
    • Uemura R, Xu M, Ahmad N, Ashraf M (2006) Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res 98:1414-1421
    • (2006) Circ Res , vol.98 , pp. 1414-1421
    • Uemura, R.1    Xu, M.2    Ahmad, N.3    Ashraf, M.4
  • 34
    • 33846395496 scopus 로고    scopus 로고
    • In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function
    • Xu M, Uemura R, Dai Y, Wang Y, Pasha Z, Ashraf M (2007) In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function. J Mol Cell Cardiol 42:441-448
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 441-448
    • Xu, M.1    Uemura, R.2    Dai, Y.3    Wang, Y.4    Pasha, Z.5    Ashraf, M.6
  • 35
    • 33750576151 scopus 로고    scopus 로고
    • Intravenous administration of vascular endothelial growth factor improves cardiac performance and inhibits cardiomyocyte apoptosis
    • Ruixing Y, Jiaquan L, Jie C, Dezhai Y (2006) Intravenous administration of vascular endothelial growth factor improves cardiac performance and inhibits cardiomyocyte apoptosis. Growth Factors 24:209-217
    • (2006) Growth Factors , vol.24 , pp. 209-217
    • Ruixing, Y.1    Jiaquan, L.2    Jie, C.3    Dezhai, Y.4
  • 36
    • 0037388886 scopus 로고    scopus 로고
    • Protective effect of basic fibroblast growth factor against myocyte death and arrhythmias in acute myocardial infarction in rats
    • Nishida S, Nagamine H, Tanaka Y, Watanabe G (2003) Protective effect of basic fibroblast growth factor against myocyte death and arrhythmias in acute myocardial infarction in rats. Circ J 67:334-339
    • (2003) Circ J , vol.67 , pp. 334-339
    • Nishida, S.1    Nagamine, H.2    Tanaka, Y.3    Watanabe, G.4
  • 37
    • 36749001126 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 improves the efficacy of mesenchymal stem cells transplantation in a rat model of myocardial infarction
    • Guo J, Lin G, Bao C, Hu Z, Chu H, Hu M (2008) Insulin-like growth factor 1 improves the efficacy of mesenchymal stem cells transplantation in a rat model of myocardial infarction. J Biomed Sci 15:89-97
    • (2008) J Biomed Sci , vol.15 , pp. 89-97
    • Guo, J.1    Lin, G.2    Bao, C.3    Hu, Z.4    Chu, H.5    Hu, M.6
  • 38
    • 0346096913 scopus 로고    scopus 로고
    • Beneficial effects of GH/IGF-1 on skeletal muscle atrophy and function in experimental heart failure
    • Dalla Libera L, Ravara B, Volterrani M et al (2004) Beneficial effects of GH/IGF-1 on skeletal muscle atrophy and function in experimental heart failure. Am J Physiol Cell Physiol 286:C138-C144
    • (2004) Am J Physiol Cell Physiol , vol.286
    • Dalla Libera, L.1    Ravara, B.2    Volterrani, M.3
  • 39
    • 24644444609 scopus 로고    scopus 로고
    • Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: Role of phosphatidylinositol 3-kinase/AKT kinase
    • 9 Suppl
    • Kupatt C, Hinkel R, Lamparter M et al (2005) Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: role of phosphatidylinositol 3-kinase/AKT kinase. Circulation 112(9 Suppl):I117-I122
    • (2005) Circulation , vol.112
    • Kupatt, C.1    Hinkel, R.2    Lamparter, M.3
  • 40
    • 0033965483 scopus 로고    scopus 로고
    • Akt takes center stage in angiogenesis signaling.
    • Dimmeler S, Zeiher AM (2000) Akt takes center stage in angiogenesis signaling. Circ Res 86:4-5
    • (2000) Circ Res , vol.86 , pp. 4-5
    • Dimmeler, S.1    Zeiher, A.M.2
  • 41
    • 0034652392 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
    • Jiang BH, Zheng JZ, Aoki M, Vogt PK (2000) Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci USA 97:1749-1753
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1749-1753
    • Jiang, B.H.1    Zheng, J.Z.2    Aoki, M.3    Vogt, P.K.4
  • 42
    • 0037023634 scopus 로고    scopus 로고
    • Double-edged role of statins in angiogenesis signaling
    • Urbich C, Dernbach E, Zeiher AM, Dimmeler S (2002) Double-edged role of statins in angiogenesis signaling. Circ Res 90:737-744
    • (2002) Circ Res , vol.90 , pp. 737-744
    • Urbich, C.1    Dernbach, E.2    Zeiher, A.M.3    Dimmeler, S.4
  • 43
    • 19444364509 scopus 로고    scopus 로고
    • Statins and the risk of colorectal cancer
    • Poynter JN, Gruber SB, Higgins PD et al (2005) Statins and the risk of colorectal cancer. N Engl J Med 352:2184-2192
    • (2005) N Engl J Med , vol.352 , pp. 2184-2192
    • Poynter, J.N.1    Gruber, S.B.2    Higgins, P.D.3
  • 44
    • 0033529171 scopus 로고    scopus 로고
    • Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase
    • Rao S, Porter DC, Chen X, Herliczek T, Lowe M, Keyomarsi K (1999) Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. Proc Natl Acad Sci USA 96:7797-7802
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7797-7802
    • Rao, S.1    Porter, D.C.2    Chen, X.3    Herliczek, T.4    Lowe, M.5    Keyomarsi, K.6
  • 45
    • 0032859782 scopus 로고    scopus 로고
    • Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac
    • Agarwal B, Rao CV, Bhendwal S et al (1999) Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac. Gastroenterology 117:838-847
    • (1999) Gastroenterology , vol.117 , pp. 838-847
    • Agarwal, B.1    Rao, C.V.2    Bhendwal, S.3
  • 46
    • 29044440878 scopus 로고    scopus 로고
    • Anti-angiogenic and anti-inflammatory effects of statins: Relevance to anti-cancer therapy
    • Dulak J, Józkowicz A (2005) Anti-angiogenic and anti-inflammatory effects of statins: relevance to anti-cancer therapy. Curr Cancer Drug Targets 5:579-594
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 579-594
    • Dulak, J.1    Józkowicz, A.2
  • 47
    • 33846448142 scopus 로고    scopus 로고
    • Cholesterol, statins and cancer
    • Brown AJ (2007) Cholesterol, statins and cancer. Clin Exp Pharmacol Physiol 34:135-141
    • (2007) Clin Exp Pharmacol Physiol , vol.34 , pp. 135-141
    • Brown, A.J.1
  • 48
    • 0033914187 scopus 로고    scopus 로고
    • Follow-up study of patients randomized in the Scandinavian simvastatin survival study (4S) of cholesterol lowering
    • Pedersen TR, Wilhelmsen L, Faergeman O et al (2000) Follow-up study of patients randomized in the Scandinavian simvastatin survival study (4S) of cholesterol lowering. Am J Cardiol 86:257-262
    • (2000) Am J Cardiol , vol.86 , pp. 257-262
    • Pedersen, T.R.1    Wilhelmsen, L.2    Faergeman, O.3
  • 49
    • 4444252160 scopus 로고    scopus 로고
    • Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S)
    • Strandberg TE, Pyörälä K, Cook TJ et al (2004) Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S). Lancet 364:771-777
    • (2004) Lancet , vol.364 , pp. 771-777
    • Strandberg, T.E.1    Pyörälä, K.2    Cook, T.J.3
  • 51
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial
    • Shepherd J, Blauw GJ, Murphy MB et al (2002) Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 360:1623-1630
    • (2002) Lancet , vol.360 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.