Inhibition of telomerase in canine cancer cells following telomestatin treatment

Veterinary and Comparative Oncology

Volumn 5, Issue 2, 2007, Pages 99-107

  Long, S ^a,c   Argyle, D J ^b   Gault, E A ^a   Nasir, L ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cancer cell lines; Dogs; Telomerase; Telomestatin

Indexed keywords

CANIS FAMILIARIS;

EID: 44849141306     PISSN: 14765810     EISSN: 14765829     Source Type: Journal    
DOI: 10.1111/j.1476-5829.2006.00118.x     Document Type: Article

References (37)

1. Blackburn EH. Structure and function of telomeres. Nature 1991; 350: 569-573.
2. Harley CB, Futcher AB and Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345: 458-460.
3. Kipling D. Telomeres, replicative senescence and human ageing. Maturitas 2001; 38: 25-37.
4. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL and Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-2015.
5. Shay JW and Bacchetti S. A survey of telomerase activity in human cancer, European Journal of Cancer 1997; 33: 787-791.
6. Wright WE, Piatyszek MA, Rainey WE, Byrd W and Shay YW. Telomerase activity in human germline and embryonic tissues and cells. Developmental genetics 1996; 18: 173-179.
7. Broccoli D, Young JW and de Lange T. Telomerase activity in normal and malignant hematopoietic cells, Proceedings of the National Academy of Sciences of the USA 1995; 92: 9082-9086.
8. Counter CM, Gupta J, Harley CB, Leber B and Bacchetti S. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 1995; 85: 2315-2320.
9. Hiyama K, Hirai Y, Kyoizumi S, Akiyama M, Hiyama E, Piatyszek MA, Shay JW, Ishioka S and Yamakido M. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. Journal of Immunology 1995; 155: 3711-3715.
10. Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, Bacchetti S, Haber DA and Weinberg RA. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997; 90: 785-795.
11. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB and Cech TR. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997; 277: 955-959.
12. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S and Wright WE. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-352.
13. Counter CM, Meyerson M, Eaton EN, Ellisen LW, Caddle SD, Haber DA and Weinberg RA. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene 1998; 16: 1217-1222.
14. Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A, Beijersbergen RL, Knoll JH, Meyerson M and Weinberg RA. Inhibition of telomerase limits the growth of human cancer cells. Nature Medicine 1999; 5: 1164-1170.
15. Yazawa M, Okuda M, Setoguchi A, Nishimura R, Sasaki N, Hasegawa A, Watari T and Tsujimoto H. Measurement of telomerase activity in dog tumors. The Journal of Veterinary Medical Science 1999; 61: 1125-1129.
16. M Yazawa, M. Okuda, A. Setoguchi, Iwabuchi S, Nishimura R, Sasaki N, Masuda K, Ohno K and Tsujimoto H. Telomere length and telomerase activity in canine mammary gland tumors. American Journal of Veterinary Research 2001; 62: 1539-1543.
17. Biller BJ, Kitchell BE and Cadile CD. Evaluation of an assay for detecting telomerase activity in neoplastic tissues of dogs. American Journal of Veterinary Research 1998; 59: 1526-1529.
18. Funakoshi Y, Nakayama H, Uetsuka K, Nishimura R, Sasaki N and Doi K. Cellular proliferative and telomerase activity in canine mammary gland tumors. Veterinary Pathology 2000; 37: 177-183.
19. Argyle DJ and Nasir L Telomerase: A potential diagnostic and therapeutic tool in canine oncology. Veterinary Pathology 2003; 40: 1-7.
20. Nasir L, Devlin P, Mckevitt T, Rutteman G and Argyle DJ. Telomere lengths and telomerase activity in dog tissues: A potential model system to study human telomere and telomerase biology. Neoplasia 2001; 3: 351-359.
21. Kim MY, Vankayalapati H, Shin-Ya K, Wierzba K and Hurley LH. Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. Journal of the American Chemical Society 2002; 124: 20981-2099.
22. Pennarun G, Granotier C, Gauthier LR, Gomez D, Hoffschir F, Mandine E, Riou JF, Mergny JL, Mailliet P and Boussin FD. Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene 2005; 24: 2917-2928.
23. Shammas MA, Shmookler Reis RJ, Li C, Koley H, Hurley LH, Anderson KC and Munshi NC. Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Clinical Cancer Research 2004; 10: 770-776.
24. Tauchi T, Shin-Ya K, Sashida G, Sumi M, Nakajima A, Shimamoto T, Ohyashiki JH and Ohyashiki K. Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: Involvement of ATM-dependent DNA damage response pathways. Oncogene 2003; 22: 5338-5347.
25. Kim MY, Gleason-Guzman M, Izbicka E, Nishioka D and Hurley LH. The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures. Cancer Research 2003; 63: 3247-3256.
26. van Engeland M, Nieland LJW, Ramaekers FCS, Schutte B and Reutelingsperger CP. Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 1998; 31: 1-9.
27. Burger AM, Dai F, Schultes CM, Reszka AP, Moore MJ, Double JA and Neidle S. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Research 2005; 65: 1489-1496.
28. Akiyama M, Hideshima T, Shammas MA, Hayashi T, Hamasaki M, Tai YT, Richardson P, Gryaznov S, Munshi NC and Anderson KC. Effects of oligonucleotide N3'→P5' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells. Cancer Research 2003; 63: 6187-6194.
29. Kelsey JL, Moore AS and Glickman LT. Epidemiologic studies of risk factors for cancer in pet dogs. Epidemiologic Reviews 1998; 20: 204-217.
30. Hansen K and Khanna C. Spontaneous and genetically engineered animal models: Use in preclinical cancer drug development. European Journal of Cancer 2004; 40: 858-880.
31. Lingaas F, Comstock KE, Kirkness EF, Sorensen A, Aarskaug T, Hitte C, Nickerson ML, Moe L, Schmidt LS, Thomas R, Breen M, Galibert F, Zhar B and Ostrander EA. A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog. Human Molecular Genetics 2003; 12: 3043-3053.
32. Kirkness EF, Bafna V, Halpern AL, Levy S, Remington K, Rusch DB, Delcher AL, Pop M, Wang W, Fraser CM and Venter JC. The dog genome: Survey sequencing and comparative analysis. Science 2003; 301: 1898-1903.
33. Guyon R, Lorentzen TD, Hitte C, Kim L, Cadieu E, Parker HG, Quignon P, Lowe JK, Renier C, Gelfenbeyn B, Vignaux F, DeFrance HB, Gloux S, Mahairas GG, Andre C, Galibert F and Ostrander EA. A 1-Mb resolution radiation hybrid map of the canine genome. Proceedings of the National Academy of Sciences of the U S A 2003; 100: 5296-5301.
34. Breen M, Jouquand S, Renier C, Mellersh CS, Hitte C, Holmes NG, Cheron A, Suter N, Vignaux F, Bristow AE, Priat C, Mclann E, Andre C, Boundy S, Gitsham P, Thomas R, Bridge WL, Spriggs HF, Ryder EJ, Curson A, Sampson J, Ostrauder EA, Binns MM and Galibert F. Chromosome-specific single locus FISH probes allow anchorage of an 1800-marker integrated radiation-hybrid/linkage map of the dog genome to all chromosomes. Genome Research 2001; 11: 1784-1795.
35. Cooper GM, Brudno M, Green ED, Batzoglou S and Sidow A. Quantitative estimates of sequence divergence for comparative analyses of mammalian genomes, Genome Research 2003; 13: 813-820.
36. Withrow SJ and MacEwan EG. Small Animal Clinical Oncology. Philadelphia, W.B. Saunders, 2001.
37. Thomson SAM, Kennerly E, Olby N, Mickelson JR, Hofmann DE, Dickinson PJ, Gibson G and Breen M. Microarray analysis of differentially expressed genes of primary tumors in the canine central nervous system. Veterinary Pathology 2005; 42: 550-558.