Personality and serotonin transporter genotype interact with social context to affect immunity and viral set-point in simian immunodeficiency virus disease

Brain, Behavior, and Immunity

Volumn 22, Issue 5, 2008, Pages 676-689

  Capitanio, John P ^a,b   Abel, Kristina ^a   Mendoza, Sally P ^a   Blozis, Shelley A ^a,b   McChesney, Michael B ^a   Cole, Steve W ^c,d   Mason, William A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ROSS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AIDS; Antibody; Coping; Cortisol; Interferon; Personality; Rhesus monkey; Serotonin transporter promoter polymorphism; Simian immunodeficiency virus; Stress

Indexed keywords

ALPHA INTERFERON; CHEMOKINE RECEPTOR CXCR3; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN G; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; GENOTYPE; IMMUNE DEFICIENCY; IMMUNITY; MALE; NONHUMAN; PERSONALITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIMIAN IMMUNODEFICIENCY VIRUS; SOCIAL ENVIRONMENT; SOCIAL INTERACTION;

AGGRESSION; ANIMALS; ANTIBODIES, VIRAL; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; GENOTYPE; HYDROCORTISONE; IMMUNITY; IMMUNOGLOBULIN G; INTERFERON TYPE I; MACACA MULATTA; MALE; POLYMERASE CHAIN REACTION; RECEPTORS, CXCR3; RNA, VIRAL; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; SOCIAL BEHAVIOR; STRESS, PSYCHOLOGICAL; VIRAL LOAD; VIRUS REPLICATION;

EID: 44749094636     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2007.05.006     Document Type: Article

References (52)

1. Abel K., Alegria-Hartman M.J., Rothaeusler K., Marthas M., and Miller C.J. The relationship between simian immunodeficiency virus RNA levels and the mRNA levels of alpha/beta interferons (IFN-α/β) and IFN-α/β-inducible Mx in lymphoid tissues of rhesus macaques during acute and chronic infection. J. Virol. 76 (2002) 8433-8445
2. Abel K., La Franco-Scheuch L., Rourke T., Ma Z.-M., de Silva V., Fallert B., Beckett L., Reinhart T.A., and Miller C.J. Gamma interferon-mediated inflammation is associated with lack of protection from intravaginal simian immunodeficiency virus SIVmac239 challenge in simian-human immunodeficiency virus 89.6-immunized rhesus macaques. J. Virol. 78 (2004) 841-854
3. Ahmed R.K., Biberfeld G., and Thorstensson R. Innate immunity in experimental SIV infection and vaccination. Mol. Immunol. 42 (2005) 251-258
4. Barr C.S., Newman T.K., Becker M.L., Parker C.C., Champoux M., Lesch K.P., Goldman D., Suomi S.J., and Higley J.D. The utility of the non-human primate model for studying gene by environment interactions in behavioral research. Genes Brain Behav. 2 (2003) 336-340
5. Bennett A.J., Lesch K.P., Heils A., Long J.C., Lorenz J.G., Shoaf S.E., Champoux M., Suomi S.J., Linnoila M.V., and Higley J.D. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol. Psychiatry 7 (2002) 118-122
6. Biron C.A. Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections. Sem. Immunol. 10 (1998) 383-390
7. Capitanio J.P. Personality dimensions in adult male rhesus macaques: prediction of behaviors across time and situation. Am. J. Primatol. 47 (1999) 299-320
8. Capitanio J.P. Sociability and responses to video playbacks in adult male rhesus monkeys (Macaca mulatta). Primates 43 (2002) 169-177
9. Capitanio J.P. Personality factors between and within species. In: Thierry B., Singh M., and Kaumanns W. (Eds). Macaque Societies: a Model for the Study of Social Organizations (2004), Cambridge University Press, Cambridge 13-33
10. Capitanio J.P., and Lerche N.W. Social separation, housing relocation, and survival in simian AIDS: a retrospective analysis. Psychosom. Med. 60 (1998) 235-244
11. Capitanio J.P., Mendoza S.P., and Baroncelli S. The relationship of personality dimensions in adult male rhesus macaques to progression of simian immunodeficiency virus disease. Brain Behav. Immun. 13 (1999) 138-154
12. Capitanio J.P., Mendoza S.P., Lerche N.W., and Mason W.A. Social stress results in altered glucocorticoid regulation and shorter survival in simian acquired immune deficiency syndrome. Proc. Nat. Acad. Sci. 95 (1998) 4714-4719
13. Capitanio J.P., and Widaman K.F. Confirmatory factor analysis of personality structure in adult male rhesus monkeys (Macaca mulatta). Am. J. Primatol. 65 (2005) 289-294
14. Caspi A., and Moffitt T.E. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat. Rev. Neurosci. 7 (2006) 583-590
15. Coates T.J., Temoshok L., and Mandel J. Psychosocial research is essential to understanding and treating AIDS. Amer. Psychol. 39 (1984) 1309-1314
16. Cole S.W., Kemeny M.E., Fahey J.L., Zack J.A., and Naliboff B.D. Psychological risk factors for HIV pathogenesis: mediation by the autonomic nervous system. Biol. Psychiatry 54 (2003) 1444-1456
17. Cole S.W., Kemeny M.E., and Taylor S.E. Social identity and physical health: accelerated HIV progression in rejection-sensitive gay men. J. Pers. Soc. Psychol. 72 (1997) 320-335
18. Cole S.W., Korin Y.D., Fahey J.L., and Zack J.A. Norepinephrine accelerates HIV replication via protein Kinase A-dependent effects on cytokine production. J. Immunol. 161 (1998) 610-616
19. Cole S.W., Nailiboff B.D., Kemeny M.E., Griswold M.P., Fahey J.L., and Zack J.A. Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity. Proc. Nat. Acad. Sci. 98 (2001) 12695-12700
20. Daniel M.D., Letvin N.L., Sehgal P.K., Hunsmann G., Schmidt D.K., King N.W., and Desrosiers R.C. Long-term persistent infection of macaque monkeys with the simian immunodeficiency virus. J. Gen. Virol. 68 (1987) 3183-3189
21. Desrosiers R.C., Wyand M.S., Kodama T., Ringler D.J., Arthur L.O., Sehgal P.K., Letvin N.L., King N.W., and Daniel M.D. Vaccine protection against simian immunodeficiency virus infection. Proc. Nat. Acad. Sci. 86 (1989) 6353-6357
22. Eysenck H.J. Personality, stress and disease: an interactionist perspective. Psychol. Inq. 2 (1991) 221-232
23. Gosling S.D., and John O.P. Personality dimensions in nonhuman animals: a cross-species review. Curr. Dir. Psychol. Sci. 8 (1999) 69-75
24. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., and Lesch K.P. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66 (1996) 2621-2624
25. Holmes A., Murphy D.L., and Crawley J.N. Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol. Psychiatry 15 (2003) 953-959
26. Kemeny M.E., and Dean L. Effects of AIDS-related bereavement on HIV progression amon New York city gay me. AIDS Educ. Prev. 7 (1995) 36-47
27. Lesch K.P., Meyer J., Glatz K., Flugge G., Hinney A., Hebebrand J., Klauck S.M., Poustka A., Poutska F., Bengel D., Mossner R., Riederer P., and Heils A. The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: alternative biallelic variation in rhesus monkeys. J. Neural Transm. 104 (1997) 1259-1266
28. Leserman J., Petitto J.M., Gaynes B.N., Barroso J., Golden R.N., Perkins D.O., Folds J.D., and Evans D.L. Progression to AIDS, a clinical AIDS condition and mortality: psychosocial and physiological predictors. Psychol. Med. 32 (2002) 1059-1073
29. Leserman J., Petitto J.M., Golden R.N., Gaynes B.N., Gu H., Perkins D.O., Silva S.G., Folds J.D., and Evans D.L. Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS. Amer. J. Psychiatry 157 (2000) 1221-1228
30. Leutenegger C.M., Higgins J., Matthews T.B., Tarantal A.F., Luciw P.A., Pedersen N.C., and North T.W. Real-time TaqMan PCR as a specific and more sensitive alternative to the branched-chain DNA assay for quantitation of simian immunodeficiency virus RNA. AIDS Res. Hum. Retrovir. 17 (2001) 243-251
31. Levy J.A., Scott I., and Mackewicz C. Protection from HIV/AIDS: the importance of innate immunity. Clin. Immunol. 108 (2003) 167-174
32. Li Q., Duan L., Estes J.D., Ma Z.-M., Rourke T., Wang Y., Reilly C., Carlis J., and Miller C.J. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 434 (2005) 1148-1152
33. Lu X., Kiyono H., Lu D., Kawabata S., Torten J., Srinivasan S., Dailey P.J., McGhee J.R., Lehner T., and Miller C.J. Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251. AIDS 12 (1998) 1-10
34. Maninger N., Capitanio J.P., Mendoza S.P., and Mason W.A. Personality influences tetanus-specific antibody response in adult male rhesus macaques after removal from natal group and housing relocation. Am. J. Primatol. 61 (2003) 73-83
35. Mattapallil J.J., Douek D.C., Hill B., Nishimura Y., Martin M., and Roederer M. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 434 (2005) 1093-1097
36. McCann C.M., Song R.J., and Ruprecht R.M. Antibodies: can they protect against HIV infection?. Curr. Drug Targets Infect. Disord. 5 (2005) 95-111
37. Mellors J.W., Rinaldo Jr. C.R., Gupta P., White R.M., Todd J.A., and Kingsley L.A. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 272 (1996) 1167-1170
38. Moller J., Hallqvist J., Diderichsen F., Theorell T., Reuterwall C., and Ahlbom A. Do episodes of anger trigger myocardial infarction? A case-crossover analysis in the Stockholm Heart Epidemiology Program (SHEEP). Psychosom. Med. 61 (1999) 842-849
39. Mossner R., and Lesch K.P. Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav. Immun. 12 (1998) 249-271
40. Noldus L.P.J.J. The observer: a software system for collection and analysis of observational data. Behav. Res. Meth. Instr. Comp. 23 (1991) 415-429
41. Norbiato G., Bevilacqua M., Tarcisio V., and Clerici M. Glucocorticoids and interferon-alpha in the acquired immunodeficiency syndrome. J. Clin. Endocr. Metab. 81 (1996) 2601-2606
42. Picker L.J., and Watkins D.I. HIV pathogenesis: The first cut is the deepest. Nat. Immunol. 6 (2005) 430-432
43. Sarkar S., Kalia V., Murphey-Corb M., Montelaro R.C., and Reinhart T.A. Expression of IFN-Y induced CXCR3 agonist chemokines and compartmentalization of CXCR3+ cells in the periphery and lymph nodes of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrone. J. Med. Primatol. 32 (2003) 247-264
44. Sen G.C. Viruses and interferons. Annu. Rev. Microbiol. 55 (2001) 255-281
45. Shirazi Y., Popik W., and Pitha P.M. Modulation of interferon-mediated inhibition of human immunodeficiency virus type 1 by Tat. J. Interferon Res. 14 (1994) 259-263
46. Sloan E.K., Tarara R.P., Capitanio J.P., and Cole S.W. Enhanced SIV replication adjacent to catecholaminergic varicosities in primate lymph nodes. J. Virol. 80 (2006) 4326-4335
47. Soumelis V., Scott I., Gheyas F., Bouhour D., Cozon G., Cotte L., Huang L., Levy J.A., and Liu Y.J. Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood 98 (2001) 906-912
48. Staprans S.I., Dailey P.J., Rosenthal A., Horton C., Grant R.M., Lerche N., and Feinberg M.B. Simian immunodeficiency virus disease course is predicted by the extent of virus replication during primary infection. J. Virol. 73 (1999) 4829-4839
49. Tsao C.-W., Lin Y.-S., Cheng J.-T., Change W.-W., Chen C.-L., Wu S.-R., Fan C.-W., and Lo H.-Y. Serotonin transporter mRNA expression is decreased by lamivudine and ribavirin and increased by interferon in immune cells. Scand. J. Immunol. 63 (2006) 106-115
50. Watson A., Ranchalis J., Travis B., McClure J., Sutton W., Johnson P.R., Hu S.-L., and Haigwood N.L. Plasma viremia in macaques infected with simian immunodeficiency virus: plasma viral load early in infection predicts survival. J. Virol. 71 (1997) 284-290
51. Yehuda R., Boisoneau D., Lowy M.T., and Giller Jr. E.L. Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Arch. Gen. Psychiatry 52 (1995) 583-593
52. Zorilla E.P., Redei E., and DeRubeis R.J. Reduced cytokine levels and T-cell function in healthy males: relation to individual differences in subclinical anxiety. Brain Behav. Immun. 8 (1994) 293-312