Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251

AIDS

Volumn 12, Issue 1, 1998, Pages 1-10

  Lü, Xusheng ^a   Kiyono, Hiroshi ^b   Lu, Ding ^a   Kawabata, Shigetada ^b   Torten, Judy ^a   Srinivasan, Seema ^a   Dailey, Peter J ^c   McGhee, Jerry R ^b   Lehner, Thomas ^d   Miller, Christopher J ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d ST THOMAS HOSPITAL   (United Kingdom)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Intravaginal challenge; Rhesus macaques; Simian immunodeficiency virus; Targeted iliac lymph node; Vaginal immunity

Indexed keywords

GLYCOPROTEIN GP 120; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; PROTEIN P27; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG TARGETING; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; LYMPH NODE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROVIRUS; RECTUM; RHESUS MONKEY; SEXUAL TRANSMISSION; SIMIAN IMMUNODEFICIENCY VIRUS; SUBCUTANEOUS DRUG ADMINISTRATION; VAGINA; VAGINA SECRETION; VIRUS ENVELOPE;

ANIMALS; ANTIBODIES, VIRAL; CELLS, CULTURED; CERVIX UTERI; DISEASE TRANSMISSION, HORIZONTAL; DNA, VIRAL; FEMALE; GENE PRODUCTS, GAG; HIV ENVELOPE PROTEIN GP120; ILIUM; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; MACACA; MEMBRANE GLYCOPROTEINS; POLYMERASE CHAIN REACTION; RNA, VIRAL; SAIDS VACCINES; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VACCINES, INACTIVATED; VACCINES, SYNTHETIC; VAGINA; VIRAL ENVELOPE PROTEINS;

EID: 18744433053     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199801000-00001     Document Type: Article

References (23)

1. Over M, Piot P: Human immunodeficiency virus infection and other sexually transmitted diseases in developing counties: public health importance and priorities for resource allocation. J Infect Dis 1996, 174 (suppl 2):S162-S175.
2. Marthas M. Sutjipto S, Miller C, et al.: Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against intravenous and intravaginal challenge. In Vaccines 1992. Edited by Broun F, Chanock RM, Ginsberg HS, Lerner RA. Cold Spring Harbor: Cold Sprint; Harbor Laboratory Press; 1992:117-122.
3. Archibald DW, Witt DJ, Craven DE, Vogt MW, Hirsch MS, Essex M: Antibodies to human immunodeficiency virus in cervical secretions from women at risk for AIDS. J Infect Dis 1987, 156:2-40-241.
4. Lu X, Belec L, Martin I'MV, Pillot J: Enhanced local immunity in vaginal secretion of HIV-infected women. Lancet 1991, 338:323-324.
5. Lu XS, Belec L, I'illot J: Anti-gp160 IgG and IgA antibodies associated with a large increase in total IgG in cervicovaginal secretions from human immunodeficiency virus type 1-infecled women. J Infect Dis 1993, 167:1189-1192.
6. Miller C, Kang D, Marthas M, et al.: Genital secretory immune response to chronic SIV infection: a comparison between intra-venously and genitally inoculated rhesus macaques. Clin Exp Immunol 1992, 88:520-526.
7. Lohman BL, Miller CJ, McChesney MB: Antiviral cytotoxic T lymphocytes in the vaginal mucosa of simian immunodeficiency virus-infected rhesus macaques. J Immunol 1995, 155:5855-5860.
8. Musey L, Hu Y, Eckert L, Christensen M, Karchmcr T, McElrath MJ: HIV-1 induces cytotoxic T lymphocytes in the cervix of infected women. J Exp Med 1997, 185:293-303.
9. Daniel MD, Kirchhoff F, Czajak SC, Sehagal PB, Desrosiers RC: Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 1992, 258:1938-1941.
10. Johnston MI: Progress in AIDS vaccine development. Int Arch Allergy Immunol 1995, 108:313-317.
11. Miller CJ, McChesney MB, Lü XS, et al.: Rhesus macaques previously-infected with SHIV are protected from vaginal challenge with pathogenic SIVmac239. J Virol 1997, 71:1911-1921.
12. Lehner T, Wang Y, Cranage M, et al.: Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunity SIV envelope and core vaccine in macaques. Nature Med 1996, 2:767-775.
13. Carlson JR, McGraw TP, Keddie E, et al.: Vaccine protection of rhesus macaques against simian immunodeficiency virus infection. AIDS Res Hum Retroviruses 1 990, 6:1230-1246.
14. Lehner T, Bergmeier L, Tao L, et al.: Mucosal receptors and T-and B-cell immunity. In Development and Applications of Vaccines and Gene Therapy in AIDS. Edited by Giraldo G, Bolognesi DP, Salvatore M, Beth-Giraldo E. Basel: Karger; 1996:21-29.
15. Williams PL, Warwick R: Lymphatic drainage of the female reproductive organs. In Gray's Anatomy. 36th British Edn. Edited by Williams PL, Warwick R. Philadelphia: WB Sounders Company; 1980:798.
16. Lohman B, Higgins I, Marthas M, Marx P, Pedersen N: Development of simian immunodeficiency virus isolation, titration, and neutralization assays which use whole blood from rhesus monkeys and an antigen capture enzyme-linked immunosorbent assay. J Clin Microbiol 1991, 29:2187-2192.
17. Marthas ML, Ramos RA, Lohman HL, et al.: Viral determinants of simian immunodeficiency (SIV) virulence in rhesus macaques assessed by using attenuated and pathogenic molecular clones of SIVmac. J Virol 1993, 67:6047-6035.
18. Unger RE, Marthas ML, Lackner AA, et al.: Detection of simian immunodeficiency virus DNA in macrophages from infected rhesus macaques. J Med Primatol 1992, 21:74-81.
19. Dailey PJ, Zamroud M, Kelso R, Kolberg J, Urdea M: Quantitation of simian immunodeficiency virus (SIV) RNA in plasma of acute and chronically infected rhesus macaques using a branched DNA (bDNA) signal amplification assay. 13th Annual Symposium on Nonhuman Primate Models of AIDS. Monterey, November 1995 [abstract 99].
20. Pachl C, Todd JA, Kern DG, et al.: Rapid and precise quantification of HIV-1 RNA in plasma using a branched DNA signal amplification assay. J Acquir Immune Defic Syndr Hum Retrovirol 1995, 8:446-454.
21. Hirsch VM, Fuerst TR, Suiter G, et al.: Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara. J Virol 1996, 70:3741-3752.
22. Kawabata S, Miller CJ, Lehner T, et al.: Induction of Th2 cytokine expression for p27-specific IgA B cell responses after TLN immunization with SIV antigens in rhesus macaques. J Infect Dis (in press).
23. Ashworth LAE, Hall GA, Sharpe SA, et al.: Constitutive expression of major histocompatibility complex class II antigens on monocytes and B cells correlates with disease in simian immunodeficiency virus-infected rhesus macaques. J Infect Dis 1995, 172:1261-1267.