Expression of IFN-γ induced CXCR3 agonist chemokines and compartmentalization of CXCR3+ cells in the periphery and lymph nodes of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome

Journal of Medical Primatology

Volumn 32, Issue 4-5, 2003, Pages 247-264

  Sarkar, Surojit ^a   Kalia, Vandana ^a   Murphey Corb, Michael ^a   Montelaro, Ronald C ^a   Reinhart, Todd A ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

CXCL10 IP 10; CXCL9 MIG; CXCR3; Flow cytometry; Lymph node

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR3; CROSS REACTING ANTIBODY; GAMMA INTERFERON; HLA DR ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; CORRELATION COEFFICIENT; CYTOKINE PRODUCTION; DISEASE COURSE; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; INTRACELLULAR MEMBRANE; LYMPH NODE; LYMPHOID TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RHESUS MONKEY; RNA VIRUS INFECTION; SIMIAN IMMUNODEFICIENCY VIRUS; TH1 CELL; VIRUS LOAD; VIRUS PATHOGENESIS;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; ANTIBODIES, MONOCLONAL; BIOTIN; CHEMOKINES; CHEMOKINES, CXC; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERFERON-GAMMA, RECOMBINANT; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; MACACA MULATTA; RECEPTORS, CHEMOKINE; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; VIRAL LOAD;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA; MACACA MULATTA; RNA VIRUSES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0042974103     PISSN: 00472565     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0684.2003.00031.x     Document Type: Article

References (47)

1. Agostini C, Facco M, Siviero M, Carollo D, Galvan S, Cattelan AM, Zambello R, Trentin L, Semenzato G: CXC chemokines IP-10 and mig expression and direct migration of pulmonary CD8+/CXCR3+ T cells in the lungs of patients with HIV infection and T-cell alveolitis. Am J Respir Crit Care Med 162 (4 Pt 1): 1466-1473, 2000.
2. Arai K, Liu ZX, Lane T, Dennert G: IP-10 and Mig facilitate accumulation of T cells in the virus-infected liver. Cell Immunol 219:48-56, 2002.
3. Asensio VC, Maier J, Milner R, Boztug K, Kincaid C, Moulard M, Phillipson C, Lindsley K, Krucker T, Fox HS, Campbell IL: Interferon-independent, human immunodeficiency virus type 1 gp120-mediated induction of CXCL10/IP-10 gene expression by astrocytes in vivo and in vitro. J Virol 75:7067-7077, 2001.
4. Baggiolini M: Chemokines and leukocyte traffic. Nature 392:565-568, 1998.
5. Baggiolini M, Dewald B, Moser B: Human chemokines: an update. Annu Rev Immunol 15:675-705, 1997.
6. Basu S, Schaefer TM, Ghosh M, Fuller CL, Reinhart TA: Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines. Cytokine 18:140-148, 2002.
7. Bonecchi R, Bianchi G, Bordignon PP, D'ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, Sinigaglia F: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187:129-134, 1998.
8. Brice GT, Graber NL, Hoffman SL, Doolan DL: Expression of the chemokine MIG is a sensitive and predictive marker for antigen-specific, genetically restricted IFN-gamma production and IFN-gamma-secreting cells. J Immunol Methods 257:55-69, 2001.
9. Clements JE, Montelaro RC, Zink MC, Amedee AM, Miller S, Trichel AM, Jagerski B, Hauer D, Martin LN, Bohm RP: Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus. J Virol 69:2737-2744, 1995.
10. Clerici M, Shearer GM: A TH1 → TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 14:107-111, 1993 [comment].
11. Clerici M, Shearer GM: Cellular immunity and a type 1 cytokine profile in protection against HIV infection and progression to AIDS. Res Immunol 145:635-641; discussion 641-643, 1994.
12. Clerici M, Shearer GM: The Th1-Th2 hypothesis of HIV infection: new insights. Immunol Today 15:575-581, 1994.
13. Emilie D, Galanaud P: Cytokines and chemokines in HIV infection: implications for therapy. Int Rev Immunol 16:705-726, 1998.
14. Fallert BA, Reinhart TA: Improved detection of simian immunodeficiency virus RNA by in situ hybridization in fixed tissue sections: combined effects of temperatures for tissue fixation and probe hybridization. J Virol Methods 99:23-32, 2002.
15. Flaherty MT, Hauer DA, Mankowski JL, Zink MC, Clements JE: Molecular and biological characterization of a neurovirulent molecular clone of simian immunodeficiency virus. J Virol 71:5790-5798, 1997.
16. Giorgi JV, Detels R: T-cell subset alterations in HIV-infected homosexual men: NIAID Multicenter AIDS cohort study. Clin Immunol Immunopathol 52:10-18, 1989.
17. Herbein G: Cytokines, viruses and macrophages: an interactive network. An immune dysregulation involving the members of the tumor necrosis factor (TNF) receptor superfamily could be critical in AIDS pathogenesis. Pathol Biol 45:115-125, 1997.
18. Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A: HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Nat Med 9:191-197, 2003.
19. Kaplan G, Luster AD, Hancock G, Cohn ZA: The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med 166:1098-1108, 1987.
20. Kapoor A, Morita K, Engeman TM, Koga S, Vapnek EM, Hobart MG, Fairchild RL: Early expression of interferon-gamma inducible protein 10 and monokine induced by interferon-gamma in cardiac allografts is mediated by CD8+ T cells. Transplantation 69:1147-1155, 2000.
21. Khan IA, Maclean JA, Lee FS, Casciotti L, Dehaan E, Schwartzman JD, Luster AD: IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection. Immunity 12:483-494, 2000.
22. Klein SA, Dobmeyer JM, Dobmeyer TS, Pape M, Ottmann OG, Helm EB, Hoelzer D, Rossol R: Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry. AIDS 11:1111-1118, 1997.
23. Koga S, Auerbach MB, Engeman TM, Novick AC, Toma H, Fairchild RL: T cell infiltration into class II MHC-disparate allografts and acute rejection is dependent on the IFN-gamma-induced chemokine Mig. J Immunol 163:4878-4885, 1999.
24. Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P, Farber JM: Human Mig chemokine: biochemical and functional characterization. J Exp Med 182:1301-1314, 1995.
25. Loetscher P, Moser B, Baggiolini M: Chemokines and their receptors in lymphocyte traffic and HIV infection. Adv Immunol 74:127-180, 2000.
26. Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I: The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10 are natural antagonists for CCR3. J Biol Chem 276:2986-2991, 2001.
27. Luster AD, Ravetch JV: Biochemical characterization of a gamma interferon-inducible cytokine (IP-10). J Exp Med 166:1084-1097, 1987.
28. Mankowski JL, Flaherty MT, Spelman JP, Hauer DA, Didier PJ, Amedee AM, Murphey-Corb M, Kirstein LM, Munoz A, Clements JE, Zink MC: Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence. J Virol 71:6055-6060, 1997.
29. Melter M, Exeni A, Reinders ME, Fang JC, Mcmahon G, Gagz P, Hancock WW, Briscoe DM: Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection. Circulation 104:2558-2564, 2001.
30. Murphy PM, Baggiolini M, Charo IF, Hebert CA, Horuk R, Matsushima K, Miller LH, Oppenheim JJ, Power CA: International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev 52:145-176, 2000.
31. Narumi S, Tominaga Y, Tamaru M, Shimai S, Okumura H, Nishioji K, Itoh Y, Okanoue T: Expression of IFN-inducible protein-10 in chronic hepatitis. J Immunol 158:5536-5544, 1997.
32. Reinhart TA, Fallert BA, Pfeifer ME, Sanghavi S, Capuano S, 3rd, Rajakumar P, Murphey-Corb M, Day R, Fuller CL, Schaefer TM: Increased expression of the inflammatory chemokine CXC chemokine ligand 9/ monokine induced by interferon-gamma in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome. Blood 99:3119-3128, 2002.
33. Sallusto F, Lanzavecchia A, Mackay CR: Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today 19:568-574, 1998.
34. Sallusto F, Mackay CR, Lanzavecchia A: The role of chemokine receptors in primary, effector, and memory immune responses. Annu Rev Immunol 18:593-620, 2000.
35. Sarkar S, Kalia V, Murphey-Corb M, Montelaro RC: Characterization of CD4+ T helper cell fine specificity to the envelope glycoproteins of simian immunodeficiency virus. J Med Primatol 31:194-204, 2002.
36. Sarkar S, Kalia V, Murphey-Corb M, Montelaro RC: Detailed analysis of CD4(+) Th responses to envelope and gag proteins of simian immunodeficiency virus reveals an exclusion of broadly reactive Th epitopes from the glycosylated regions of envelope. J Immunol 168:4001-4011, 2002.
37. Shearer GM, Clerici M: Cytokine profiles in HIV type 1 disease and protection. AIDS Res Hum Retroviruses 14 (Suppl. 2):S149-S152, 1998.
38. Shearer WT, Rosenblatt HM, Schluchter MD, Mofenson LM, Denny TN: Immunologic targets of HIV infection: T cells. NICHD IVIG Clinical Trial Group, and the NHLBI P2C2 Pediatric Pulmonary and Cardiac Complications of HIV Infection Study Group. Ann N y Acad Sci 693:35-51, 1993.
39. Suni MA, Picker LJ, Maino VC: Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry. J Immunol Methods 212:89-98, 1998.
40. Tokuriki A, Seo N, Ito T, Kumakiri M, Takigawa M, Tokura Y: Dominant expression of CXCR3 is associated with induced expression of IP-10 at hapten-challenged sites of murine contact hypersensitivity: a possible role for interferon-gamma-producing CD8(+) T cells in IP-10 expression. J Dermatol Sci 28:234-241, 2002.
41. Valdez H, Gripshover BM, Salata RA, Lederman MM: Resolution of azole-resistant oropharyngeal candidiasis after initiation of potent combination antiretroviral therapy. AIDS 12:538, 1998.
42. Valdez H, Lederman MM: Cytokines and cytokine therapies in HIV infection. AIDS Clin Rev 187-228, 1997.
43. Vergis EN, Mellors JW: Natural history of HIV-1 infection. Infect Dis Clin North Am 14:809-825, 2000.
44. Villinger F, Brar SS, Mayne A, CHikkala N, Ansari AA: Comparative sequence analysis of cytokine genes from human and nonhuman primates. J Immunol 155:3946-3954, 1995.
45. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, Demartino JA: Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem 273:18288-18291, 1998.
46. Yoneyama H, Narumi S, Zhang Y, Murai M, Baggiolini M, Lanzavecchia A, Ichida T, Asakura H, Matsushima K: Pivotal role of dendritic cell-derived CXCL10 in the retention of T helper cell 1 lymphocytes in secondary lymph nodes. J Exp Med 195:1257-1266, 2002.
47. Zlotnik A, Yoshie O: Chemokines: a new classification system and their role in immunity. Immunity 12:121-127, 2000.