Duocarmycin-based prodrugs for cancer prodrug monotherapy

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 12, 2008, Pages 6312-6318

  Tietze, Lutz F ^a   Schuster, Heiko J ^a   Schmuck, Kianga ^a   Schuberth, Ingrid ^a   Alves, Frauke ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Antitumor agents; Cancer therapy; Cytotoxicity; Duocarmycin; Glucuronides; Prodrugs

Indexed keywords

BETA GLUCURONIDASE; DUOCARMYCIN A; GLUCURONIC ACID; GLUCURONIDE; PHENOL; PRODRUG; TRICHLOROACETIMIDIC ACID;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DEPROTECTION REACTION; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; MONOTHERAPY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; GLUCURONIC ACID; GLUCURONIC ACIDS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; NEOPLASMS; PRODRUGS; PYRROLES;

EID: 44649194513     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.009     Document Type: Article

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