Investigation of reactivity and selectivity of DNA-alkylating duocarmycin analogues by high-resolution mass spectrometry

Angewandte Chemie - International Edition

Volumn 45, Issue 39, 2006, Pages 6570-6574

  Tietze, Lutz F ^a   Krewer, Birgit ^a   Frauendorf, Holm ^a   Major, Felix ^a   Schuberth, Ingrid ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Alkylation; DNA; Duocarmycin; Mass spectrometry

Indexed keywords

DNA ALKYLATION; DUOCARMYCIN; OLIGODEOXYNUCLEOTIDE;

ALKYLATION; CATALYST SELECTIVITY; DNA; MASS SPECTROMETRY; REACTION KINETICS;

DRUG PRODUCTS;

ALKYLATING AGENT; DNA; DNA FRAGMENT; DUOCARMYCIN SA; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; INDOLE DERIVATIVE; PRODRUG; PYRROLE DERIVATIVE;

ARTICLE; CELL SURVIVAL; CHEMISTRY; DNA FRAGMENTATION; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ALKYLATING AGENTS; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DNA; DNA FRAGMENTATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; INDICATORS AND REAGENTS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PRODRUGS; PYRROLES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33749827504     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200600935     Document Type: Article

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