Enantio- And diastereoselective synthesis of duocarmycine-based prodrugs for a selective treatment of cancer by epoxide opening

Chemistry - A European Journal

Volumn 14, Issue 3, 2008, Pages 895-901

  Tietze, Lutz F ^a   Schuster, Heiko J ^a   Hampel, Sonja M ^a   Rühl, Stephan ^a   Pfoh, Roland ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Appel reactions; Cuprates; Epoxides; Prodrugs; Total synthesis

Indexed keywords

CYCLIZATION; ONCOLOGY; REACTION KINETICS; STEREOSELECTIVITY; SYNTHESIS (CHEMICAL); TUMORS;

APPEL REACTIONS; DIASTEREOSELECTIVE SYNTHESIS; EPOXIDE OPENING; HYDROXY GROUPS;

ANTIBIOTICS;

2 PYRROLIDONE DERIVATIVE; ANTINEOPLASTIC AGENT; DUOCARMYCIN A; EPOXIDE; INDOLE DERIVATIVE; PRODRUG;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; CYCLIZATION; NEOPLASM; STEREOISOMERISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; EPOXY COMPOUNDS; INDOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEOPLASMS; PRODRUGS; PYRROLIDINONES; STEREOISOMERISM;

EID: 38849095316     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200700988     Document Type: Article

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