Strategies to Cure Experimental Autoimmune Colitis Using Antigen-Specific Foxp3+ Regulatory T Cells

Gastroenterology

Volumn 134, Issue 7, 2008, Pages 2171-2174

  de Zoeten, Edwin F ^a   Hancock, Wayne W ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

AUTOIMMUNE DISEASE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; COLITIS; DISEASE MODEL; EDITORIAL; ENTERITIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH2 CELL; TH3 CELL;

EID: 44649176479     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.04.030     Document Type: Editorial

References (27)

1. + regulatory T cells. Gastroenterology 134 (2008) 2014-2024
2. Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4 (2003) 330-336
3. Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
4. Ramsdell F. Foxp3 and natural regulatory T cells: key to a cell lineage?. Immunity 19 (2003) 165-168
5. Sakaguchi S. The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery. J Clin Invest 112 (2003) 1310-1312
6. Brunkow M.E., Jeffery E.W., Hjerrild K.A., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 27 (2001) 68-73
7. Singh B., Read S., Asseman C., et al. Control of intestinal inflammation by regulatory T cells. Immunol Rev 182 (2001) 190-200
8. Mottet C., Uhlig H.H., and Powrie F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 170 (2003) 3939-3943
9. Wildin R.S., Ramsdell F., Peake J., et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet 27 (2001) 18-20
10. Duchmann R., Kaiser I., Hermann E., et al. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 102 (1995) 448-455
11. Mudter J., Wirtz S., Galle P.R., et al. A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis. Pathobiology 70 (2002) 170-176
12. Wirtz S., and Neurath M.F. Mouse models of inflammatory bowel disease. Adv Drug Deliv Rev 59 (2007) 1073-1083
13. Klein L., Khazaie K., and von Boehmer H. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc Natl Acad Sci U S A 100 (2003) 8886-8891
14. Tang Q., Henriksen K.J., Bi M., et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199 (2004) 1455-1465
15. Verginis P., McLaughlin K.A., Wucherpfennig K.W., et al. Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc Natl Acad Sci U S A 105 (2008) 3479-3484
16. Cong Y., Konrad A., Iqbal N., et al. Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function. J Immunol 174 (2005) 2787-2795
17. Miller A., Lider O., and Weiner H.L. Antigen-driven bystander suppression after oral administration of antigens. J Exp Med 174 (1991) 791-798
18. Khoury S.J., Hancock W.W., and Weiner H.L. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 176 (1992) 1355-1364
19. Cobbold S.P., Adams E., Graca L., et al. Immune privilege induced by regulatory T cells in transplantation tolerance. Immunol Rev 213 (2006) 239-255
20. Chen W., Jin W., Hardegen N., et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198 (2003) 1875-1886
21. Battaglia M., Stabilini A., and Roncarolo M.G. Rapamycin selectively expands CD4+CD25+FOXP3+ regulatory T cells. Blood 105 (2005) 4743-4748
22. Pillai V., Ortega S.B., Wang C.K., et al. Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol 123 (2007) 18-29
23. Mucida D., Park Y., Kim G., et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317 (2007) 256-260
24. Baron U., Floess S., Wieczorek G., et al. DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol 37 (2007) 2378-2389
25. Chen C., Rowell E.A., Thomas R.M., et al. Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J Biol Chem 281 (2006) 36828-36834
26. Tao R., de Zoeten E.F., Ozkaynak E., et al. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 13 (2007) 1299-1307
27. + T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J Exp Med 201 (2005) 1037-1044