The innate immune response to adjuvants dictates the adaptive immune response to autoantigens

Journal of Neuropathology and Experimental Neurology

Volumn 67, Issue 6, 2008, Pages 543-554

  Staykova, Maria A ^a,c   Liñares, David ^a   Fordham, Susan A ^a   Paridaen, Judith T ^a,b   Willenborg, David O ^a,b  

^a Biology and Environment   (Australia)

^b The Australian National University   (Australia)

^c CANBERRA HOSPITAL   (Australia)

Author keywords

Autoimmune; Experimental autoimmune encephalomyelitis; Innate immunity; Microglia; Multiple sclerosis; Nitric oxide

Indexed keywords

AUTOANTIGEN; FREUND ADJUVANT;

ADAPTIVE IMMUNITY; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; HOMOGENATE; IMMUNIZATION; INFLAMMATION; INNATE IMMUNITY; MICROGLIA; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; AUTOANTIGENS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FLOW CYTOMETRY; FREUND'S ADJUVANT; GENETIC PREDISPOSITION TO DISEASE; IMMUNITY, NATURAL; IMMUNOHISTOCHEMISTRY; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERFERON TYPE II; IRON COMPOUNDS; MACROPHAGE ACTIVATION; NITRIC OXIDE; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD; T-LYMPHOCYTES;

EID: 44649160704     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e31817713cc     Document Type: Article

References (48)

1. Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005:23;683-747
2. Oksenberg JR, Barcellos LF. Multiple sclerosis genetics: Leaving no stone unturned. Genes Immun 2005:6;375-87
3. Andersson A, Karlsson J. Genetics of experimental autoimmune encephalomyelitis in the mouse. Arch Immunol Ther Exp (Warsz) 2004:52;316-25
4. Becanovic K, Jagodic M, Wallstrom E, Olsson T. Current gene-mapping strategies in experimental models of multiple sclerosis. Scand J Immunol 2004:60;39-51
5. Olsson T, Dahlman I, Wallstrom E, Weissert R, Piehl F. Genetics of rat neuroinflammation. J Neuroimmunol 2000:107;191-200
6. Hellings N, Raus J, Stinissen P. Insights into the immunopathogenesis of multiple sclerosis. Immunol Res 2002:25;27-51
7. Martin R, McFarland HF, McFarlin DE. Immunological aspects of demyelinating diseases. Annu Rev Immunol 1992:10;153-87
8. Seamons A, Perchellet A, Goverman J. Immune tolerance to myelin proteins. Immunol Res 2003:28;201-21
9. Stinissen P, Raus J, Zhang J. Autoimmune pathogenesis of multiple sclerosis: Role of autoreactive T lymphocytes and new immunotherapeutic strategies. Crit Rev Immunol 1997:17;33-75
10. Happ MP, Wettstein P, Dietzschold B, Heber-Katz E. Genetic control of the development of experimental allergic encephalomyelitis in rats. Separation of MHC and non-MHC gene effects. J Immunol 1988:141;1489-94
11. Muhallab S, Dahlman I, Wallstrom E. Disparate MHC class II haplotypes in myelin oligodendrocyte glycoprotein- and myelin basic protein-induced experimental autoimmune encephalomyelitis. J Neuroimmunol 2005:161;155-61
12. Stefferl A, Brehm U, Storch M, et al. Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the resistant Brown Norway rat: Disease susceptibility is determined by MHC and MHC-linked effects on the B cell response. J Immunol 1999:163;40-49
13. Weissert R, de Graaf KL, Storch MK, et al. MHC class II-regulated central nervous system autoaggression and T cell responses in peripheral lymphoid tissues are dissociated in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J Immunol 2001:166;7588-99
14. MacPhee IA, Antoni FA, Mason DW. Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids. J Exp Med 1989:169;431-45
15. Mason D, MacPhee I, Antoni F. The role of the neuroendocrine system in determining genetic susceptibility to experimental allergic encephalomyelitis in the rat. Immunology 1990:70;1-5
16. Villas PA, Dronsfield MJ, Blankenhorn EP. Experimental allergic encephalomyelitis and corticosterone studies in resistant and susceptible rat strains. Clin Immunol Immunopathol 1991:61;29-40
17. Willenborg DO, Staykova MA, Cowden WB. Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: A review. J Neuroimmunol 1999:100;21-35
18. Staykova MA, Berven LA, Cowden WB, Willenborg DO, Crouch MF. Nitric oxide induces polarization of actin in encephalitogenic T cells and inhibits their in vitro trans-endothelial migration in a p70S6 kinase-independent manner. FASEB J 2003:17;1337-39
19. Fournie GJ, Cautain B, Xystrakis E, et al. Cellular and genetic factors involved in the difference between Brown Norway and Lewis rats to develop respectively type-2 and type-1 immune-mediated diseases. Immunol Rev 2001:184;145-60
20. Gasser DL, Palm J, Gonatas NK. Genetic control of susceptibility to experimental allergic encephalomyelitis and the Ag-B locus of rats. J Immunol 1975:115;431-33
21. Williams RM, Moore MJ. Linkage of susceptibility to experimental allergic encephalomyelitis to the major histocompatibility locus in the rat. J Exp Med 1973:138;775-83
22. van der Meide PH, de Labie MC, Botman CA, Aten J, Weening JJ. Nitric oxide suppresses IFN-gamma production in the spleen of mercuric chloride-exposed brown Norway rats. Cell Immunol 1995:161;195-206
23. Lafaille JJ, Keere FV, Hsu AL, et al. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J Exp Med 1997:186;307-12
24. Levine S, Sowinski R. Carbonyl iron: A new adjuvant for experimental autoimmune diseases. J Immunol 1970:105;1530-35
25. Staykova MA, Paridaen JT, Cowden WB, Willenborg DO. Nitric oxide contributes to resistance of the Brown Norway rat to experimental autoimmune encephalomyelitis. Am J Pathol 2005:166;147-57
26. Cowden WB, Cullen FA, Staykova MA, Willenborg DO. Nitric oxide is a potential down-regulating molecule in autoimmune disease: inhibition of nitric oxide production renders PVG rats highly susceptible to EAE. J Neuroimmunol 1998:88;1-8
27. Corraliza IM, Campo ML, Soler G, Modolell M. Determination of arginase activity in macrophages: A micromethod. J Immunol Methods 1994:174;231-35
28. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001:25;402-8
29. Popko B, Corbin JG, Baerwald KD, Dupree J, Garcia AM. The effects of interferon-gamma on the central nervous system. Mol Neurobiol 1997:14;19-35
30. Bronte V, Zanovello P. Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol 2005:5;641-54
31. Grohmann U, Fallarino F, Puccetti P. Tolerance, DCs and tryptophan: Much ado about IDO. Trends Immunol 2003:24;242-48
32. Mellor AL, Munn DH. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004:4;762-74
33. Harris NL, Ronchese F. The role of B7 costimulation in T-cell immunity. Immunol Cell Biol 1999:77;304-11
34. Benveniste EN. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med 1997:75;165-73
35. Bonetti B, Pohl J, Gao YL, Raine CS. Cell death during autoimmune demyelination: Effect or but not target cells are eliminated by apoptosis. J Immunol 1997:159;5733-41
36. Nguyen KB, McCombe PA, Pender MP. Increased apoptosis of T lymphocytes and macrophages in the central and peripheral nervous systems of Lewis rats with experimental autoimmune encephalomyelitis treated with dexamethasone. J Neuropathol Exp Neurol 1997:56;58-69
37. White CA, McCombe PA, Pender MP. Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95). Int Immunol 1998:10;935-41
38. Gold R, Linington C, Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006:129;1953-71
39. Swanborg RH. Experimental autoimmune encephalomyelitis in the rat: lessons in T-cell immunology and autoreactivity. Immunol Rev 2001:184;129-35
40. Weissert R, Wallstrom E, Storch MK, et al. MHC haplotype-dependent regulation of MOG-induced EAE in rats. J Clin Invest 1998:102;1265-73
41. Pagany M, Jagodic M, Bourquin C, Olsson T, Linington C. Genetic variation in myelin oligodendrocyte glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis. J Neuroimmunol 2003:139;1-8
42. Widner B, Ledochowski M, Fuchs D. Interferon-gamma-induced tryptophan degradation: Neuropsychiatric and immunological consequences. Curr Drug Metab 2000:1;193-204
43. Staykova MA, Cowden W, Willenborg DO. Macrophages and nitric oxide as the possible cellular and molecular basis for strain and gender differences in susceptibility to autoimmune central nervous system inflammation. Immunol Cell Biol 2002:80;188-97
44. Billiau A, Matthys P. Modes of action of Freund's adjuvants in experimental models of autoimmune diseases. J Leukoc Biol 2001:70;849-60
45. Bomford R. Will adjuvants be needed for vaccines of the future? Dev Biol Stand 1998:92;13-17
46. Hendriks JJ, Teunissen CE, de Vries HE, Dijkstra CD. Macrophages and neurodegeneration. Brain Res Brain Res Rev 2005:48;185-95
47. Jander S, Stoll G. Strain-specific expression of microglial keratan sulfate proteoglycans in the normal rat central nervous system: Inverse correlation with constitutive expression of major histocompatibility complex class II antigens. Glia 1996:18;255-60
48. Sedgwick JD, Schwender S, Gregersen R, Dorries R, ter Meulen V. Resident macrophages (ramified microglia) of the adult Brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive. J Exp Med 1993:177;1145-52