Genetic variation in myelin oligodendrocyte glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis

Journal of Neuroimmunology

Volumn 139, Issue 1-2, 2003, Pages 1-8

  Pagany, Maria ^a   Jagodic, Maja ^b   Bourquin, Carole ^a   Olsson, Tomas ^b   Linington, Christopher ^a,c  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

EAE; Genetic susceptibility; MOG; Protein expression; Tolerance

Indexed keywords

MESSENGER RNA; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; NERVOUS SYSTEM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPECIES COMPARISON; TARGET ORGAN;

EID: 0038797820     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(03)00124-3     Document Type: Article

References (30)

1. Bernard C.C., Johns T.G., Slavin A., Ichikawa M., Ewing C., Liu J., Bettadapura J. Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis. J. Mol. Med. 75:1997;77-88.
2. Brunner C., Lassmann H., Waehneldt T.V., Matthieu J.M., Linington C. Differential ultrastructural localization of myelin basic protein, myelin/oligodendroglial glycoprotein, and 2′,3′-cyclic nucleotide 3′-phosphodiesterase in the CNS of adult rats. J. Neurochem. 52:1989;296-304.
3. Bruno R., Sabater L., Sospedra M., Ferrer-Francesch X., Escudero D., Martinez-Caceres E., Pujol-Borrell R. Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus. Eur. J. Immunol. 32:2002;2737-2747.
4. Dahlman I., Wallstrom E., Weissert R., Storch M., Kornek B., Jacobsson L., Linington C., Luthman H., Lassmann H., Olsson T. Linkage analysis of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the rat identifies a locus controlling demyelination on chromosome 18. Hum. Mol. Genet. 8:1999;2183-2190.
5. Daubas P., Pham-Dinh D., Dautigny A. Structure and polymorphism of the mouse myelin/oligodendrocyte glycoprotein gene. Genomics. 23:1994;36-41.
6. Delarasse, C., Daubas, P., Vizler, C., Della Gaspera, B., Decker, L., Goude, K., Bauer, J., Litzenburger, T., Iglesias, A., Schubart, A., Dimitri, D., Dierich, A., LeMeur, M., Roussel, G., Nussbaum, L., Pham-Dinh, D., Liblau, R., Dautigny, A., submitted for publication. Myelin/Oligodendrocyte Glycoprotein (MOG)-deficient mice reveal lack of tolerance to MOG in wild-type mice.
7. Derbinski J., Schulte A., Kyewski B., Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2:2001;1032-1039.
8. Egwuagu C.E., Charukamnoetkanok P., Gery I. Thymic expression of autoantigens correlates with resistance to autoimmune disease. J. Immunol. 159:1997;3109-3112.
9. Genain C.P., Cannella B., Hauser S.L., Raine C.S. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat. Med. 5:1999;170-175.
10. Gomez-Lira M., Marzari M.G., Uziel G., Pignatti P., Rizzuto N., Salviati A. Myelin oligodendrocyte glycoprotein (MOG) polymorphisms and adrenoleukodystrophy. J. Neuroimmunol. 111(1-2):2000;245-247.
11. Gunn C.A., Richards M.K., Linington C. The immune response to myelin proteolipid protein in the Lewis rat: identification of the immunodominant B cell epitope. J. Neuroimmunol. 27:1990;155-162.
12. Ioannidu S., Walter L., Dressel R., Gunther E. Physical map and expression profile of genes of the telomeric class I gene region of the rat MHC. J. Immunol. 166(6):2001;3957-3965.
13. Klein L., Klugmann M., Nave K.A., Tuohy V.K., Kyewski B. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6:2000;56-61.
14. Lambracht D., Prokop C., Hedrich H.J., Fischer L.K., Wonigeit K. Mapping of H2-M homolog and MOG genes in the rat MHC. Immunogenetics. 42:1995;418-421.
15. Linnington C., Webb M., Woodhams P.L. A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody. J. Neuroimmunol. 6:1984;387-396.
16. Litzenburger T., Fassler R., Bauer J., Lassmann H., Linington C., Wekerle H., Iglesias A. B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice. J. Exp. Med. 188:1998;169-180.
17. Liu H., MacKenzie-Graham A.J., Kim S., Voskuhl R.R. Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance. J. Neuroimmunol. 115:2001;118-126.
18. Malfroy L., Viratelle C., Coppin H., Borot N., Roth M.P. Polymorphic tri- and tetranucleotide repeats in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene. Hum. Genet. 96:1995;737-738.
19. Martin R., McFarland H.F., McFarlin D.E. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 10:1992;153-187.
20. Oksenberg J.R., Seboun E., Hauser S.L. Genetics of demyelinating diseases. Brain Pathol. 6:1996;289-302.
21. Pham-Dinh D., Mattei M.G., Nussbaum J.L., Roussel G., Pontarotti P., Roeckel N., Mather I.H., Artzt K., Lindahl K.F., Dautigny A. Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. Proc. Natl. Acad. Sci. U. S. A. 90:1993;7990-7994.
22. Pham-Dinh D., Jones E.P., Pitiot G., Della G.B., Daubas P., Mallet J., Le Paslier D., Fischer L.K., Dautigny A. Physical mapping of the human and mouse MOG gene at the distal end of the MHC class Ib region. Immunogenetics. 42:1995;386-391.
23. Piddlesden S.J., Storch M.K., Hibbs M., Freeman A.M., Lassmann H., Morgan B.P. Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis. J. Immunol. 152:1994;5477-5484.
24. Rodriguez D., Della Gaspera B., Zalc B., Hauw J.J., Fontaine B., Edan G., Clanet M., Dautigny A., Pham-Dinh D. Identification of a Val I45 Ile substitution in the human myelin oligodendrocyte glycoprotein: lack of association with multiple sclerosis. Mult. Scler. 3(6):1997;377-381.
25. Roth M.P., Dolbois L., Borot N., Amadou C., Clanet M., Pontarotti P., Coppin H. Three highly polymorphic microsatellites at the human myelin oligodendrocyte glycoprotein locus, 100 kb telomeric to HLA-F. Characterization and relation to HLA haplotypes. Hum. Immunol. 43:1995;276-282.
26. Seboun E., Oksenberg J.R., Rombos A., Usuku K., Goodkin D.E., Lincoln R.R., Wong M., Pham-Dinh D., Boesplug-Tanguy O., Carsique R., Fitoussi R., Gartioux C., Reyes C., Ribierre F., Faure S., Fizames C., Gyapay G., Weissenbach J., Dautigny A., Rimmler J.B., Garcia M.E., Pericak-Vance M.A., Haines J.L., Hauser S.L. Linkage analysis of candidate myelin genes in familial multiple sclerosis. Neurogenetics. 2(3):1999;155-162.
27. Solly S.K., Daubas P., Monge M., Dautigny A., Zalc B. Functional analysis of the mouse myelin/oligodendrocyte glycoprotein gene promoter in the oligodendroglial CG4 cell line. J. Neurochem. 68:1997;1705-1711.
28. Stefferl A., Brehm U., Storch M., Lambracht-Washington D., Bourquin C., Wonigeit K., Lassmann H., Linington C. Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the "resistant" Brown Norway rat: disease susceptibility is determined by MHC and MHC-linked effects on the B cell response. J. Immunol. 163:1999;40-49.
29. Storch M.K., Stefferl A., Brehm U., Weissert R., Wallstrom E., Kerschensteiner M., Olsson T., Linington C., Lassmann H. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol. 8:1998;681-694.
30. Weissert R., Wallstrom E., Storch M.K., Stefferl A., Lorentzen J., Lassmann H., Linington C., Olsson T. MHC haplotype-dependent regulation of MOG-induced EAE in rats. J. Clin. Invest. 102:1998;1265-1273.