Defensins Versus Bacteria: Not Just Antibiotics Anymore

Gastroenterology

Volumn 134, Issue 7, 2008, Pages 2174-2177

  Salzman, Nita H ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; ANTITOXIN; BETA DEFENSIN; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; DEFENSIN; EXOTOXIN;

CLOSTRIDIUM DIFFICILE; EDITORIAL; HOST RESISTANCE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 44649158420     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.04.028     Document Type: Editorial

References (28)

1. Kelly C.P., and LaMont J.T. Clostridium difficile infection. Annu Rev Med 49 (1998) 375-390
2. Bartlett J.G., and Perl T.M. The new Clostridium difficile-what does it mean?. N Engl J Med 353 (2005) 2503-2505
3. Voth D.E., and Ballard J.D. Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev 18 (2005) 247-263
4. Giesemann T., Guttenberg G., and Aktories K. Human α-defensins inhibit Clostridium difficile toxin B. Gastroenterology 134 (2008) 2049-2058
5. Boman H.G. Peptide antibiotics and their role in innate immunity. Annu Rev Immunol 13 (1995) 61-92
6. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 415 (2002) 389-395
7. Maemoto A., Qu X., Rosengren K.J., et al. Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem 279 (2004) 44188-44196
8. Mandal M., and Nagarau R. Antibacterial activities and conformations of synthetic a-defensin HNP-1 and analogs with one, two and three disulfide bridges. J Pept Res 59 (2002) 95-104
9. Lehrer R.I., Bevins C.L., and Ganz T. Defensins and other antimicrobial peptides. In: Mestecky J., Bienstock J., Lamm M.E., et al. (Eds). Mucosal Immunology. 3rd ed. (2005), Academic Press, New York 95-110
10. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 3 (2003) 710-720
11. Yang D., Chertov O., Bykovskaia S.N., et al. b-Defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286 (1999) 525-528
12. Yang D., Biragyn A., Hoover D.M., et al. Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu Rev Immunol 22 (2004) 181-215
13. Wang W., Mulakala C., Ward S.C., et al. Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin. J Biol Chem 281 (2006) 32755-32764
14. Kim C., Slavinskaya Z., Merrill A.R., et al. Human alpha-defensins neutralize toxins of the mono-ADP-ribosyltransferase family. Biochem J 399 (2006) 225-229
15. Kim C., and Kaufmann S.H. Defensin: a multifunctional molecule lives up to its versatile name. Trends Microbiol 14 (2006) 428-431
16. Kim C., Gajendran N., Mittrucker H.W., et al. Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences. Proc Natl Acad Sci U S A 102 (2005) 4830-4835
17. Lehrer R.I. Multispecific myeloid defensins. Curr Opin Hematol 14 (2007) 16-21
18. Selsted M.E., and Ouellette A.J. Mammalian defensins in the antimicrobial immune response. Nat Immunol 6 (2005) 551-557
19. Ericksen B., Wu Z., Lu W., et al. Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob Agents Chemother 49 (2005) 269-275
20. Porter E., Liu L., Oren A., et al. Localization of human intestinal defensin 5 in Paneth cell granules. Infect Immun 65 (1997) 2389-2395
21. Porter E.M., Bevins C.L., Ghosh D., et al. The multifaceted Paneth cell. Cell Mol Life Sci 59 (2002) 156-170
22. Hooper L.V., Stappenbeck T.S., Hong C.V., et al. Angiogenins: an new class of microbicidal proteins involved in innate immunity. Nat Immunol 4 (2003) 269-273
23. Cash H.L., Whitham C.V., Behrendt C.L., et al. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. [see comment]. Science 313 (2006) 1126-1130
24. Ouellette A.J., and Bevins C.L. Paneth cell defensins and innate immunity of the small bowel. Inflamm Bowel Dis 7 (2001) 43-50
25. Hornef M.W., Putsep K., Karlsson J., et al. Increased diversity of intestinal antimicrobial peptides by covalent dimer formation. Nat Immunol 5 (2004) 836-843
26. Salzman N.H., Ghosh D., Huttner K.M., et al. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422 (2003) 522-526
27. Wehkamp J., Salzman N.H., Porter E., et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 102 (2005) 18129-18134
28. Kraus D., and Peschel A. Molecular mechanisms of bacterial resistance to antimicrobial peptides. Curr Top Microbiol Immunol 306 (2006) 231-250