-
1
-
-
0037267313
-
Knockouts model the 100 best-selling drugs - will they model the next 100?
-
Zambrowicz B.P., and Sands A.T. Knockouts model the 100 best-selling drugs - will they model the next 100?. Nat. Rev. Drug Discov. 2 (2003) 38-51
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 38-51
-
-
Zambrowicz, B.P.1
Sands, A.T.2
-
2
-
-
0024335875
-
The rat as an experimental animal
-
Gill III T.J., et al. The rat as an experimental animal. Science 245 (1989) 269-276
-
(1989)
Science
, vol.245
, pp. 269-276
-
-
Gill III, T.J.1
-
3
-
-
0025239301
-
Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene
-
Mullins J.J., et al. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 344 (1990) 541-544
-
(1990)
Nature
, vol.344
, pp. 541-544
-
-
Mullins, J.J.1
-
4
-
-
0025633436
-
Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders
-
Hammer R.E., et al. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell 63 (1990) 1099-1112
-
(1990)
Cell
, vol.63
, pp. 1099-1112
-
-
Hammer, R.E.1
-
5
-
-
8144221194
-
Genetically engineered animals in drug discovery and development: a maturing resource for toxicologic research
-
Bolon B. Genetically engineered animals in drug discovery and development: a maturing resource for toxicologic research. Basic Clin. Pharmacol. Toxicol. 95 (2004) 154-161
-
(2004)
Basic Clin. Pharmacol. Toxicol.
, vol.95
, pp. 154-161
-
-
Bolon, B.1
-
6
-
-
27144501108
-
Transgenic modifications of the rat genome
-
Tesson L., et al. Transgenic modifications of the rat genome. Transgenic Res. 14 (2005) 531-546
-
(2005)
Transgenic Res.
, vol.14
, pp. 531-546
-
-
Tesson, L.1
-
7
-
-
0026753520
-
Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes
-
Ganten D., et al. Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 7806-7810
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 7806-7810
-
-
Ganten, D.1
-
8
-
-
0037128659
-
Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1
-
Keppler O.T., et al. Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1. J. Exp. Med. 195 (2002) 719-736
-
(2002)
J. Exp. Med.
, vol.195
, pp. 719-736
-
-
Keppler, O.T.1
-
9
-
-
33846505602
-
HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcription
-
Goffinet C., et al. HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcription. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 1015-1020
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 1015-1020
-
-
Goffinet, C.1
-
10
-
-
0037444426
-
Transgenic rat model of Huntington's disease
-
von Horsten S., et al. Transgenic rat model of Huntington's disease. Hum. Mol. Genet. 12 (2003) 617-624
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 617-624
-
-
von Horsten, S.1
-
11
-
-
0032735679
-
Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein
-
Herrera V.L., et al. Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein. Nat. Med. 5 (1999) 1383-1389
-
(1999)
Nat. Med.
, vol.5
, pp. 1383-1389
-
-
Herrera, V.L.1
-
12
-
-
0035704592
-
Pronuclear microinjection
-
Wall R.J. Pronuclear microinjection. Cloning Stem Cells 3 (2001) 209-220
-
(2001)
Cloning Stem Cells
, vol.3
, pp. 209-220
-
-
Wall, R.J.1
-
13
-
-
0020665081
-
Ovulation response and fertilization failure in immature rats induced to superovulate
-
Walton E.A., et al. Ovulation response and fertilization failure in immature rats induced to superovulate. J. Reprod. Fertil. 67 (1983) 91-96
-
(1983)
J. Reprod. Fertil.
, vol.67
, pp. 91-96
-
-
Walton, E.A.1
-
14
-
-
0030197964
-
Transgenesis in rats: technical aspects and models
-
Charreau B., et al. Transgenesis in rats: technical aspects and models. Transgenic Res. 5 (1996) 223-234
-
(1996)
Transgenic Res.
, vol.5
, pp. 223-234
-
-
Charreau, B.1
-
15
-
-
3142723251
-
Lentivirally generated eGFP-transgenic rats allow efficient cell tracking in vivo
-
van den Brandt J., et al. Lentivirally generated eGFP-transgenic rats allow efficient cell tracking in vivo. Genesis 39 (2004) 94-99
-
(2004)
Genesis
, vol.39
, pp. 94-99
-
-
van den Brandt, J.1
-
16
-
-
0036468677
-
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors
-
Lois C., et al. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295 (2002) 868-872
-
(2002)
Science
, vol.295
, pp. 868-872
-
-
Lois, C.1
-
17
-
-
34547112080
-
Efficient transgenic rat production by a lentiviral vector
-
Michalkiewicz M., et al. Efficient transgenic rat production by a lentiviral vector. Am. J. Physiol. Heart Circ. Physiol. 293 (2007) H881-H894
-
(2007)
Am. J. Physiol. Heart Circ. Physiol.
, vol.293
-
-
Michalkiewicz, M.1
-
18
-
-
0037133212
-
Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos
-
Pfeifer A., et al. Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 2140-2145
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 2140-2145
-
-
Pfeifer, A.1
-
19
-
-
34548386205
-
New technology for an old favorite: lentiviral transgenesis and RNAi in rats
-
Dann C.T. New technology for an old favorite: lentiviral transgenesis and RNAi in rats. Transgenic Res. 16 (2007) 571-580
-
(2007)
Transgenic Res.
, vol.16
, pp. 571-580
-
-
Dann, C.T.1
-
20
-
-
33646384957
-
RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function
-
Lee J.Y., et al. RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J. Biol. Chem. 281 (2006) 2649-2653
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 2649-2653
-
-
Lee, J.Y.1
-
21
-
-
0036467996
-
Insulators: many functions, many mechanisms
-
West A.G., et al. Insulators: many functions, many mechanisms. Genes Dev. 16 (2002) 271-288
-
(2002)
Genes Dev.
, vol.16
, pp. 271-288
-
-
West, A.G.1
-
22
-
-
0027464687
-
A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice
-
Schedl A., et al. A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice. Nature 362 (1993) 258-261
-
(1993)
Nature
, vol.362
, pp. 258-261
-
-
Schedl, A.1
-
23
-
-
0034220360
-
Generation of transgenic rats with YACs and BACs: preparation procedures and integrity of microinjected DNA
-
Takahashi R., et al. Generation of transgenic rats with YACs and BACs: preparation procedures and integrity of microinjected DNA. Exp. Anim. 49 (2000) 229-233
-
(2000)
Exp. Anim.
, vol.49
, pp. 229-233
-
-
Takahashi, R.1
-
24
-
-
0030958229
-
Position-independent and high-level expression of human alpha-lactalbumin in the milk of transgenic rats carrying a 210-kb YAC DNA
-
Fujiwara Y., et al. Position-independent and high-level expression of human alpha-lactalbumin in the milk of transgenic rats carrying a 210-kb YAC DNA. Mol. Reprod. Dev. 47 (1997) 157-163
-
(1997)
Mol. Reprod. Dev.
, vol.47
, pp. 157-163
-
-
Fujiwara, Y.1
-
25
-
-
0026722596
-
Secretion of bovine alpha-lactalbumin into the milk of transgenic rats
-
Hochi S., et al. Secretion of bovine alpha-lactalbumin into the milk of transgenic rats. Mol. Reprod. Dev. 33 (1992) 160-164
-
(1992)
Mol. Reprod. Dev.
, vol.33
, pp. 160-164
-
-
Hochi, S.1
-
26
-
-
0024790207
-
Efficient tissue-specific expression of bovine alpha-lactalbumin in transgenic mice
-
Vilotte J.L., et al. Efficient tissue-specific expression of bovine alpha-lactalbumin in transgenic mice. Eur. J. Biochem. 186 (1989) 43-48
-
(1989)
Eur. J. Biochem.
, vol.186
, pp. 43-48
-
-
Vilotte, J.L.1
-
27
-
-
0028469708
-
Variation in expression of a bovine alpha-lactalbumin transgene in milk of transgenic mice
-
Bleck G.T., and Bremel R.D. Variation in expression of a bovine alpha-lactalbumin transgene in milk of transgenic mice. J. Dairy Sci. 77 (1994) 1897-1904
-
(1994)
J. Dairy Sci.
, vol.77
, pp. 1897-1904
-
-
Bleck, G.T.1
Bremel, R.D.2
-
28
-
-
9744234386
-
Efficient generation of transgenic mice with intact yeast artificial chromosomes by intracytoplasmic sperm injection
-
Moreira P.N., et al. Efficient generation of transgenic mice with intact yeast artificial chromosomes by intracytoplasmic sperm injection. Biol. Reprod. 71 (2004) 1943-1947
-
(2004)
Biol. Reprod.
, vol.71
, pp. 1943-1947
-
-
Moreira, P.N.1
-
29
-
-
0027451043
-
A method for the generation of YAC transgenic mice by pronuclear microinjection
-
Schedl A., et al. A method for the generation of YAC transgenic mice by pronuclear microinjection. Nucleic Acids Res. 21 (1993) 4783-4787
-
(1993)
Nucleic Acids Res.
, vol.21
, pp. 4783-4787
-
-
Schedl, A.1
-
30
-
-
6944224385
-
Establishment of an efficient BAC transgenesis protocol and its application to functional characterization of the mouse Brachyury locus
-
Abe K., et al. Establishment of an efficient BAC transgenesis protocol and its application to functional characterization of the mouse Brachyury locus. Exp. Anim. 53 (2004) 311-320
-
(2004)
Exp. Anim.
, vol.53
, pp. 311-320
-
-
Abe, K.1
-
31
-
-
25444515938
-
Production of inbred and hybrid transgenic mice carrying large (>200 kb) foreign DNA fragments by intracytoplasmic sperm injection
-
Osada T., et al. Production of inbred and hybrid transgenic mice carrying large (>200 kb) foreign DNA fragments by intracytoplasmic sperm injection. Mol. Reprod. Dev. 72 (2005) 329-335
-
(2005)
Mol. Reprod. Dev.
, vol.72
, pp. 329-335
-
-
Osada, T.1
-
32
-
-
0036000263
-
Offspring derived from intracytoplasmic injection of transgenic rat sperm
-
Hirabayash M., et al. Offspring derived from intracytoplasmic injection of transgenic rat sperm. Transgenic Res. 11 (2002) 221-228
-
(2002)
Transgenic Res.
, vol.11
, pp. 221-228
-
-
Hirabayash, M.1
-
33
-
-
4444287530
-
Production of transgenic rats by ooplasmic injection of spermatogenic cells exposed to exogenous DNA: a preliminary study
-
Kato M., et al. Production of transgenic rats by ooplasmic injection of spermatogenic cells exposed to exogenous DNA: a preliminary study. Mol. Reprod. Dev. 69 (2004) 153-158
-
(2004)
Mol. Reprod. Dev.
, vol.69
, pp. 153-158
-
-
Kato, M.1
-
34
-
-
14644414837
-
Factors affecting production of transgenic rats by ICSI-mediated DNA transfer: effects of sonication and freeze-thawing of spermatozoa, rat strains for sperm and oocyte donors, and different constructs of exogenous DNA
-
Hirabayashi M., et al. Factors affecting production of transgenic rats by ICSI-mediated DNA transfer: effects of sonication and freeze-thawing of spermatozoa, rat strains for sperm and oocyte donors, and different constructs of exogenous DNA. Mol. Reprod. Dev. 70 (2005) 422-428
-
(2005)
Mol. Reprod. Dev.
, vol.70
, pp. 422-428
-
-
Hirabayashi, M.1
-
35
-
-
0026638820
-
Targeted oncogene activation by site-specific recombination in transgenic mice
-
Lakso M., et al. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 6232-6236
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 6232-6236
-
-
Lakso, M.1
-
36
-
-
2942516779
-
Establishment of Cre/LoxP recombination system in transgenic rats
-
Sato Y., et al. Establishment of Cre/LoxP recombination system in transgenic rats. Biochem. Biophys. Res. Commun. 319 (2004) 1197-1202
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.319
, pp. 1197-1202
-
-
Sato, Y.1
-
37
-
-
33845361229
-
Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas
-
Ueda S., et al. Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas. Carcinogenesis 27 (2006) 2497-2510
-
(2006)
Carcinogenesis
, vol.27
, pp. 2497-2510
-
-
Ueda, S.1
-
38
-
-
16244392116
-
Composite tissue transplantation in rats: fusion of donor muscle to the recipient site
-
Ajiki T., et al. Composite tissue transplantation in rats: fusion of donor muscle to the recipient site. Transplant. Proc. 37 (2005) 208-209
-
(2005)
Transplant. Proc.
, vol.37
, pp. 208-209
-
-
Ajiki, T.1
-
39
-
-
20044379768
-
Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo
-
Means A.L., et al. Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo. Genesis 42 (2005) 23-27
-
(2005)
Genesis
, vol.42
, pp. 23-27
-
-
Means, A.L.1
-
40
-
-
34548651693
-
Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs
-
Gong S., et al. Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs. J. Neurosci. 27 (2007) 9817-9823
-
(2007)
J. Neurosci.
, vol.27
, pp. 9817-9823
-
-
Gong, S.1
-
41
-
-
33846585042
-
Expression of Cre recombinase in dopaminoceptive neurons
-
Lemberger T., et al. Expression of Cre recombinase in dopaminoceptive neurons. BMC Neurosci. 8 (2007) 4
-
(2007)
BMC Neurosci.
, vol.8
, pp. 4
-
-
Lemberger, T.1
-
42
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen M., and Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 5547-5551
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
43
-
-
0037868847
-
Generation of heme oxygenase-1-transgenic rats
-
Braudeau C., et al. Generation of heme oxygenase-1-transgenic rats. Exp. Biol. Med. (Maywood) 228 (2003) 466-471
-
(2003)
Exp. Biol. Med. (Maywood)
, vol.228
, pp. 466-471
-
-
Braudeau, C.1
-
44
-
-
0033135274
-
Endothelial expression of Fas ligand in transgenic rats under the temporal control of a tetracycline-inducible system
-
Tesson L., et al. Endothelial expression of Fas ligand in transgenic rats under the temporal control of a tetracycline-inducible system. Transplant. Proc. 31 (1999) 1533-1534
-
(1999)
Transplant. Proc.
, vol.31
, pp. 1533-1534
-
-
Tesson, L.1
-
45
-
-
0036821233
-
Differential sensitivity of endothelial cells of various species to apoptosis induced by gene transfer of Fas ligand: role of FLIP levels
-
Bouchet D., et al. Differential sensitivity of endothelial cells of various species to apoptosis induced by gene transfer of Fas ligand: role of FLIP levels. Mol. Med. 8 (2002) 612-623
-
(2002)
Mol. Med.
, vol.8
, pp. 612-623
-
-
Bouchet, D.1
-
46
-
-
0036884523
-
Stringent doxycycline dependent control of CRE recombinase in vivo
-
Schonig K., et al. Stringent doxycycline dependent control of CRE recombinase in vivo. Nucleic Acids Res. 30 (2002) e134
-
(2002)
Nucleic Acids Res.
, vol.30
-
-
Schonig, K.1
-
47
-
-
0029783602
-
Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons
-
Flavell D.M., et al. Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons. EMBO J. 15 (1996) 3871-3879
-
(1996)
EMBO J.
, vol.15
, pp. 3871-3879
-
-
Flavell, D.M.1
-
48
-
-
0034647522
-
Impaired estrogen sensitivity in bone by inhibiting both estrogen receptor alpha and beta pathways
-
Ogawa S., et al. Impaired estrogen sensitivity in bone by inhibiting both estrogen receptor alpha and beta pathways. J. Biol. Chem. 275 (2000) 21372-21379
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 21372-21379
-
-
Ogawa, S.1
-
49
-
-
33645217120
-
Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B
-
Langenickel T.H., et al. Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 4735-4740
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 4735-4740
-
-
Langenickel, T.H.1
-
50
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir S.M., et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
-
51
-
-
34447503838
-
Transgenic RNA interference in mice
-
Gao X., and Zhang P. Transgenic RNA interference in mice. Physiology (Bethesda) 22 (2007) 161-166
-
(2007)
Physiology (Bethesda)
, vol.22
, pp. 161-166
-
-
Gao, X.1
Zhang, P.2
-
52
-
-
0037021437
-
Small interfering RNA and gene silencing in transgenic mice and rats
-
Hasuwa H., et al. Small interfering RNA and gene silencing in transgenic mice and rats. FEBS Lett. 532 (2002) 227-230
-
(2002)
FEBS Lett.
, vol.532
, pp. 227-230
-
-
Hasuwa, H.1
-
53
-
-
33746634679
-
Heritable and stable gene knockdown in rats
-
Dann C.T., et al. Heritable and stable gene knockdown in rats. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 11246-11251
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 11246-11251
-
-
Dann, C.T.1
-
54
-
-
0037685273
-
Production of knockout rats using ENU mutagenesis and a yeast-based screening assay
-
Zan Y., et al. Production of knockout rats using ENU mutagenesis and a yeast-based screening assay. Nat. Biotechnol. 21 (2003) 645-651
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 645-651
-
-
Zan, Y.1
-
55
-
-
0346728736
-
Target-selected mutagenesis of the rat
-
Smits B.M., et al. Target-selected mutagenesis of the rat. Genomics 83 (2004) 332-334
-
(2004)
Genomics
, vol.83
, pp. 332-334
-
-
Smits, B.M.1
-
56
-
-
0242666144
-
Generation of fertile cloned rats by regulating oocyte activation
-
Zhou Q., et al. Generation of fertile cloned rats by regulating oocyte activation. Science 302 (2003) 1179
-
(2003)
Science
, vol.302
, pp. 1179
-
-
Zhou, Q.1
-
57
-
-
0037069345
-
Production of transgenic rats by lentiviral transduction of male germ-line stem cells
-
Hamra F.K., et al. Production of transgenic rats by lentiviral transduction of male germ-line stem cells. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 14931-14936
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 14931-14936
-
-
Hamra, F.K.1
-
58
-
-
33947252434
-
Efficient generation of transgenic rats through the male germline using lentiviral transduction and transplantation of spermatogonial stem cells
-
Ryu B.Y., et al. Efficient generation of transgenic rats through the male germline using lentiviral transduction and transplantation of spermatogonial stem cells. J. Androl. 28 (2007) 353-360
-
(2007)
J. Androl.
, vol.28
, pp. 353-360
-
-
Ryu, B.Y.1
|