Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1

Journal of Experimental Medicine

Volumn 195, Issue 6, 2002, Pages 719-736

  Keppler, Oliver T ^a   Welte, Frank J ^a   Ngo, Tuan A ^a   Chin, Peggy S ^a   Patton, Kathryn S ^a   Tsou, Chia Lin ^a   Abbey, Nancy W ^b   Sharkey, Mark E ^c   Grant, Robert M ^a,b   You, Yun ^a   Scarborough, John D ^d   Ellmeier, Wilfried ^d   Littman, Dan R ^d   Stevenson, Mario ^c   Charo, Israel F ^a   Herndier, Brian G ^b   Speck, Roberto F ^a   Goldsmith, Mark A ^a,c,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

Author keywords

CCR5; CD4; HIV 1; Macrophages; Transgenic rats

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; LIPOPOLYSACCHARIDE; RITONAVIR; ZIDOVUDINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOHISTOCHEMISTRY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL; T LYMPHOCYTE; TRANSGENIC ANIMAL; VIRUS INFECTION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD4; DISEASE MODELS, ANIMAL; HIV INFECTIONS; HIV-1; HUMANS; MACROPHAGES; RATS; RECEPTORS, CCR5; VIRUS REPLICATION;

EID: 0037128659     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011549     Document Type: Article

References (80)

1. Animal models of AIDS
2. Models for AIDS pathogenesis: Simian immunodeficiency virus, simian-human immunodeficiency virus and feline immunodeficiency virus infections
3. Primate models of AIDS
4. Development and applications of the SCID-hu mouse model
5. Human xenograft models for virus infection
6. Developing animal models for AIDS research - Progress and problems
7. Small animals are not susceptible to human immunodeficiency virus infection
8. Restriction of HIV-1 (subtype B) replication at the entry step in rhesus macaque cells
9. Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat
10. Species-specific, postentry barriers to primate immunodeficiency virus infection
11. Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection
12. + T cell homeostasis and in vitro HIV-1 susceptibility in transgenic mice expressing T cell line-tropic HIV-1 receptors
13. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
14. The interaction between HIV-1 tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein
15. Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation
16. A block to human immunodeficiency virus type 1 assembly in murine cells
17. Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells
18. Mouse-human heterokaryons support efficient human immunodeficiency virus type 1 assembly
19. Susceptibility of rat-derived cells to replication by human immunoficiency virus type 1
20. An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction
21. Intracerebral injection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat
22. Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum
23. CXCR4-activated astrocyte glutamate release via TNFα: Amplification by microglia triggers neurotoxicity
24. Metabolism of zidovudine
25. ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans
26. Zidovudine, diclofenac and ketoprofen pharmacokinetic interactions in rats
27. Permissive factors for HIV-1 infection of macrophages
28. Pathways to neuronal injury and apoptosis in HIV-associated dementia
29. Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands
30. Chemokine receptor allelic polymorphisms: Relationships to HIV resistance and disease progression
31. An intricate web: Chemokine receptors, HIV-1 and hematopoiesis
32. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4
33. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
34. Multiple extracellular elements of CCR5 and HIV-1 entry: Dissociation from response to chemokines
35. Characterization of a human Kaposi's sarcoma cell line that induces angiogenic tumors in animals
36. Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: Evidence that directed migration is mediated by βγ dimers released by activation of Gαi-coupled receptors
37. The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
38. Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates-definition of critical amino acids involved in cell tropism
39. Human immunodeficiency virus type 1 integrase: Effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells
40. Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection
41. Change in coreceptor use coreceptor use correlates with disease progression in HIV-1-infected individuals
42. Vpr is required for efficient replication of human inmmnodeficiency virus type-1 in mononuclear phagocytes
43. Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus
44. V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1
45. Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy
46. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
47. Recent amplification of rat ID sequences
48. Fusion-competent vaccines: Broad neutralization of primary isolates of HIV
49. Expression of CCR5 increases during monocyte differentiation and directly mediates macrophage susceptibility to infection by human immunodeficiency virus type 1
50. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro
51. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
52. Human immunodeficiency virus type 1 T-cell tropism is determined by events prior to provirus formation
53. Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes
54. Active human immunodeficiency virus protease is required for viral infectivity
55. Triggering of complement receptors CR1 (CD35) and CR3 (CD11b/CD18) induces nuclear translocation of NF-κB (p50/p65) in human monocytes and enhances viral replication in HIV-infected monocytic cells
56. Infection of HIV-1 transgenic mice with Mycobacterium avium induces the expression of infectious virus selectively from a Mac-1-positive host cell population
57. Human immunodeficiency virus type 1 infection of human CD4-transgenic rabbits
58. HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: Independence from G protein signaling and importance of coreceptor downmodulation
59. HIV-1 entry and macrophage inflammatory protein-1β-mediated signaling are independent functions of the chemokine receptor CCR5
60. Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
61. Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5
62. The role of mononuclear phagocytes in HTLV-III/LAV infection
63. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy
64. Specific tropism of HIV-1 for microglial cells in primary human brain cultures
65. Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry
66. HIV and HIV dementia
67. Detection of infectious HIV in circulating monocytes from patients on prolonged highly active antiretroviral therapy
68. Dynamics of viral load in plasma and HIV DNA in lymphocytes during highly active antiretroviral therapy (HAART): High viral burden in macrophages after 1 year of treatment
69. Macrophages as a source of HIV during opportunistic infections
70. + T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans
71. Cytotoxic T lymphocytes and HIV-1 related neurologic disorders
72. Microglia-passaged simian immunodeficiency virus induces neurophysiological abnormalities in monkeys
73. Perivascular macrophages are the primary cell type productively infected by simian immunodeficiency virus in the brains of macaques: Implications for the neuropathogenesis of AIDS
74. Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome
75. Infection of human immunodeficiency virus 1 transgenic mice with Toxoplasma gondii stimulates proviral transcription in macrophages in vivo
76. Mice transgenic for monocytetropic HIV type 1 produce infectious virus and display plasma viremia: A new in vivo system for studying the postintegration phase of HIV replication
77. Early activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and c-Jun N-terminal kinase in response to binding of simian immunodeficiency virus to Jurkat T cells expressing CCR5 receptor
78. CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopes
79. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
80. Highly restricted spread of HIV-1 and multiply infected cells within splenic germinal centers