CD4 +CD25 +regulatory T cells specific for a thymus-expressed antigen prevent the development of anaphylaxis to self

Journal of Immunology

Volumn 180, Issue 7, 2008, Pages 4433-4440

  Scabeni, Stefano ^a   Lapilla, Marilena ^a   Musio, Silvia ^a   Gallo, Barbara ^a   Ciusani, Emilio ^b   Steinman, Lawrence ^c,d   Mantegazza, Renato ^a   Pedotti, Rosetta ^a  

^a DEPARTMENT OF NEUROSURGERY   (Italy)

^b Neurological Institute Foundation Carlo Besta   (Italy)

^c Stanford University ^*  (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BASILIXIMAB; CD3 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; MESSENGER RNA; PROTEOLIPID PROTEIN; TRANSCRIPTION FACTOR FOXP3; ANTIBODY; IMMUNOGLOBULIN G;

ANAPHYLAXIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; BODY TEMPERATURE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELL SPECIFICITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; THYMUS; ANIMAL; BIOSYNTHESIS; CELL CULTURE; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPH NODE; METABOLISM; PATHOLOGY;

ANAPHYLAXIS; ANIMALS; ANTIBODIES; ANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; IMMUNIZATION; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-10; LYMPH NODES; MICE; MYELIN PROTEOLIPID PROTEIN; SELF TOLERANCE; THYMUS GLAND;

EID: 44449159981     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.7.4433     Document Type: Article

References (52)

1. 1.Bach, J. F. 2002. The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 347: 911-920.
2. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone: I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136: 2348-2357.
3. Romagnani, S. 1994. Regulation of the development of type 2 T-helper cells in allergy. Curr. Opin. Immunol. 6: 838-846.
4. Pedotti, R., D. Mitchell, J. Wedemeyer, M. Karpuj, D. Chabas, E. M. Hattab, M. Tsai, S. J. Galli, and L. Steinman. 2001. An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide. Nat. Immunol. 2: 216-222.
5. Galli, S. J. 2005. Pathogenesis and management of anaphylaxis: current status and future challenges. J. Allergy Clin. Immunol. 115: 571-574.
6. Smith, C. E., T. N. Eagar, J. L. Strominger, and S. D. Miller. 2005. Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 102: 9595-9600.
7. Lichtenegger, F. S., S. Kuerten, S. Faas, B. O. Boehm, M. Tary-Lehmann, and P. V. Lehmann. 2007. Dissociation of experimental allergic encephalomyelitis protective effect and allergic side reactions in tolerization with neuroantigen. J. Immunol. 178: 4749 -4756.
8. Klein, L., M. Klugmann, K. A. Nave, and B. Kyewski. 2000. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6: 56 -61.
9. Anderson, A. C., L. B. Nicholson, K. L. Legge, V. Turchin, H. Zaghouani, and V. K. Kuchroo. 2000. High frequency of autoreactive myelin proteolipid protein- specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J. Exp. Med. 191: 761-770.
10. Greer, J. M., V. K. Kuchroo, R. A. Sobel, and M. B. Lees. 1992. Identification and characterization of a second encephalitogenic determinant of myelin prote- olipid protein (residues 178-191) for SJL mice. J. Immunol. 149: 783-788.
11. Liu, E., H. Moriyama, N. Abiru, D. Miao, L. Yu, R. M. Taylor, F. D. Finkelman, and G. S. Eisenbarth. 2002. Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9 -23 and B:13-23. J. Clin. Invest. 110: 1021-1027.
12. + regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 101: 15434-15439.
13. Yu, P., R. K. Gregg, J. J. Bell, J. S. Ellis, R. Divekar, H. H. Lee, R. Jain, H. Waldner, J. C. Hardaway, M. Collins, et al. 2005. Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomy- elitis upon activation with cognate antigen. J. Immunol. 174: 6772-6780.
14. + regulatory cells within the central nervous system. J. Immunol. 175: 3025-3032.
15. Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, and V. K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
16. Miyajima, I., D. Dombrowicz, T. R. Martin, J. V. Ravetch, J. P. Kinet, and S. J. Galli. 1997. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and FcγRIII: assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent pas sive anaphylaxis. J. Clin. Invest. 99: 901-914.
17. Strait, R. T., S. C. Morris, M. Yang, X. W. Qu, and F. D. Finkelman. 2002. Pathways of anaphylaxis in the mouse. J. Allergy Clin. Immunol. 109: 658-668.
18. Mond, J. J., A. Lees, and C. M. Snapper. 1995. T cell-independent antigens type 2. Annu. Rev. Immunol. 13: 655-692.
19. Coffman, R. L., J. Ohara, M. W. Bond, J. Carty, A. Zlotnik, and W. E. Paul. 1986. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J. Immunol. 136: 4538 -4541.
20. Stevens, T. L., A. Bossie, V. M. Sanders, R. Fernandez-Botran, R. L. Coffman, T. R. Mosmann, and E. S. Vitetta. 1988. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334: 255-258.
21. Boom, W. H., D. Liano, and A. K. Abbas. 1988. Heterogeneity of helper/inducer T lymphocytes: II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes. J. Exp. Med. 167: 1350 -1363.
22. Bettelli, E., M. P. Das, E. D. Howard, H. L. Weiner, R. A. Sobel, and V. K. Kuchroo. 1998. IL-10 is critical in the regulation of autoimmune enceph- alomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and trans- genic mice. J. Immunol. 161: 3299 -3306.
23. Bettelli, E., L. B. Nicholson, and V. K. Kuchroo. 2003. IL-10, a key effector regulatory cytokine in experimental autoimmune encephalomyelitis. J. Autoimmun. 20: 265-267.
24. + regulatory T cells. Int. Immunol. 16: 249 -256.
25. Roncarolo, M. G., M. Battaglia, and S. Gregori. 2003. The role of interleukin 10 in the control of autoimmunity. J. Autoimmun. 20: 269 -272.
26. Hawrylowicz, C. M., and A. O'Garra. 2005. Potential role of interleukin-10- secreting regulatory T cells in allergy and asthma. Nat. Rev. Immunol. 5: 271-283.
27. Mangan, N. E., R. E. Fallon, P. Smith, N. van Rooijen, A. N. McKenzie, and P. G. Fallon. 2004. Helminth infection protects mice from anaphylaxis via IL- 10-producing B cells. J. Immunol. 173: 6346 -6356.
28. Robinson, D. S., M. Larche, and S. R. Durham. 2004. Tregs and allergic disease. J. Clin. Invest. 114: 1389 -1397.
29. + regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22: 531-562.
30. + suppressor T cells. J. Exp. Med. 193: F41-F46.
31. + regulatory cells. Autoimmun Rev. 1: 190 -197.
32. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
33. + T regulatory cells. Nat. Immunol. 4: 337-342.
34. + regulatory T cells. Nat. Immunol. 4: 330 -336.
35. Jaeckel, E., H. von Boehmer, and M. P. Manns. 2005. Antigen-specific FoxP3- transduced T-cells can control established type 1 diabetes. Diabetes 54: 306 -310.
36. + regulatory T cells. J. Immunol 177: 1552-1560.
37. + T regulatory cells. J. Immunol 176: 3301-3305.
38. + naturally anergic and suppressiveT cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10: 1969 -1980.
39. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
40. Roncarolo, M. G., R. Bacchetta, C. Bordignon, S. Narula, and M. K. Levings. 2001. Type 1 T regulatory cells. Immunol. Rev. 182: 68 -79.
41. Korn, T., J. Reddy, W. Gao, E. Bettelli, A. Awasthi, T. R. Petersen, B. T. Backstrom, R. A. Sobel, K. W. Wucherpfennig, T. B. Strom, et al. 2007. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat. Med. 13: 423-431.
42. Prod'homme, T., M. S. Weber, and S. S. Zamvil. 2007. T effectors outfox T regulators in autoimmunity. Nat. Med. 13: 411-413.
43. + T cells by grass pollen immunotherapy. J. Allergy Clin. Immunol. 111: 1255-1261.
44. Jutel, M., L. Jaeger, R. Suck, H. Meyer, H. Fiebig, and O. Cromwell. 2005. Allergen-specific immunotherapy with recombinant grass pollen allergens. J. Allergy Clin. Immunol. 116: 608-613.
45. Lin, W., N. Truong, W. J. Grossman, D. Haribhai, C. B. Williams, J. Wang, M. G. Martin, and T. A. Chatila. 2005. Allergic dysregulation and hyperimmu- noglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116: 1106 -1115.
46. Wing, K., and S. Sakaguchi. 2006. Regulatory T cells as potential immunother- apy in allergy. Curr. Opin. Allergy Clin. Immunol. 6: 482-488.
47. + regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 363: 608 -615.
48. Akdis, M., J. Verhagen, A. Taylor, F. Karamloo, C. Karagiannidis, R. Crameri, S. Thunberg, G. Deniz, R. Valenta, H. Fiebig, et al. 2004. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J. Exp. Med. 199: 1567-1575.
49. + T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J. Exp. Med. 202: 1549 -1561.
50. + regulatory T cells. J. Exp. Med. 203: 2649 -2660.
51. + T cells selectively kill B lymphocytes. Blood 107: 3925-3932.
52. Fritz, R. B., and I. Kalvakolanu. 1995. Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse. J. Neuroimmunol. 57: 93-99.