Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic parameters with a clinically active dosing schedule

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 868, Issue 1-2, 2008, Pages 110-115

  Phelps, Mitch A ^a   Rozewski, Darlene M ^b   Johnston, Jeffrey S ^b   Farley, Katherine L ^a   Albanese, Katie A ^b   Byrd, John C ^a,b,c   Lin, Thomas S ^a,c   Grever, Michael R ^a,c   Dalton, James T ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c NONE   (United States)

Author keywords

Flavopiridol; Genistein; LCMS; Pharmacokinetics; Plasma; Quantitation

Indexed keywords

BIOASSAY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PARAMETER ESTIMATION; PHARMACOKINETICS; PLASMAS;

FLAVOPIRIDOL; GENISTEIN; QUANTITATION;

METABOLITES;

ACETONITRILE; AMMONIUM FORMATE; CYCLIN DEPENDENT KINASE INHIBITOR; FLAVOPIRIDOL; GENISTEIN; ION; WATER;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DISPOSITION; DRUG DOSE REGIMEN; DRUG HALF LIFE; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIMIT OF QUANTIFICATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETER; MASS SPECTROMETRY; PARAMETER; PLASMA; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; SINGLE REACTION MONITORING; TECHNIQUE; VALIDATION PROCESS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOIDS; HUMANS; PIPERIDINES; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 44449083839     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.04.023     Document Type: Article

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