Binding of a fibrinogen mimetic stabilizes integrin αIIbβ3's open conformation

Protein Science

Volumn 10, Issue 8, 2001, Pages 1614-1626

  Hantgan, Roy R ^a   Rocco, Mattia ^b   Nagaswami, Chandrasekaran ^c   Weisel, John W ^c  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Analytical ultracentrifugation; Electron microscopy; Fibrinogen receptor; Hydrodynamics; Integrins; Ligand binding; Light scattering; Molecular modeling

Indexed keywords

EPTIFIBATIDE; FIBRINOGEN; FIBRINOGEN RECEPTOR; INTEGRIN;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; DIMERIZATION; DISSOCIATION; ELECTROPHORETIC MOBILITY; HYDRODYNAMICS; LIGAND BINDING; LIGHT SCATTERING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR OCCUPANCY; STOICHIOMETRY;

BINDING SITES; DIMERIZATION; FIBRINOGEN; HUMANS; LIGANDS; LIGHT; MODELS, MOLECULAR; PEPTIDES; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN SUBUNITS; SCATTERING, RADIATION; SPECTROMETRY, FLUORESCENCE; ULTRACENTRIFUGATION;

EID: 0034926054     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.3001     Document Type: Article

References (88)

1. RGD-containing peptides inhibit fibrinogen binding to platelet αIIbβ3 by inducing an allosteric change in the amino-terminal portion of αIIb
2. A method for determining transmembrane helix association and orientation in detergent micelles using small angle x-ray scattering
3. Hydrodynamic bead modeling of biological macromolecules
4. Other optical techniques
5. Structure of human platelet glycoproteins IIb and IIIa as determined by electron microscopy
6. Structure of adenovirus complexed with its internalization receptor, αvβ5 integrin
7. Peptide ligands can bind to distinct sites in integrin αIIbβ3 and elicit different functional responses
8. Integrins and signal transduction pathways: The road taken
9. Molecular modeling software and methods for medicinal chemistry
10. Proteins in Solution and in Membranes
11. Integrin-mediated cell adhesion: The cytoskeletal connection
12. Localization of an arg-gly-asp recognition site within an integrin adhesion receptor
13. The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its α subunit
14. Hydrodynamic properties of complex, rigid biological macromolecules: Theory and applications
15. Integrin cytoplasmic interactions and bidirectional transmembrane signalling
16. Ligand recognition by the I domain-containing integrins
17. Three-dimensional structure of the platelet integrin recognition segment of the fibrinogen (chain obtained by carrier protein-driven crystallization
18. 3
19. Structural basis of collagen recognition by integrin α2β1
20. Integrin αIIbβ3 reconstituted into lipid bilayers is nonclustered in its activated state but clusters after fibrinogen binding
21. Role of fibrinogen α and γ chain sites in platelet aggregation
22. Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone
23. Trinodular structure of fibrinogen. Confirmation by both shadowing and negative stain electron microscopy
24. Integrin signaling
25. Ligand binding to integrins: Dynamic regulation and common mechanisms
26. Eptifibatide - A review of its use in patients with acute coronary syndromes and/or undergoing percutaneous coronary intervention
27. Development of a structural model for the cytoplasmic domain of an integrin
28. 3 solution conformation
29. Inhibition of platelet adhesion to fibrin(ogen) in flowing whole blood by Arg-Gly-Asp and fibrinogen gamma-chain carboxy terminal peptides
30. Effects of ligandmimetic peptides Arg-Gly-Asp-X (X = Pre, Trp, Ser) on αIibβ3 integrin conformation and oligomerization
31. Adhesive ends of fibrinogen and its antiadhesive peptides: The end of a saga
32. Platelet receptor recognition domains on the α chain of human fibrinogen: Structure-function analysis
33. The residues AGDV of recombinant gamma chains of human fibrinogen must be carboxy-terminal to support human platelet aggregation
34. A new model of dual interacting ligand binding sites on integrin αIIbβ3
35. 2 subunit
36. Integrin affinity modulation
37. Towards a structural model of an integrin
38. Integrins: Versatility, modulation, and signaling in cell adhesion
39. Laser light scattering
40. Analysis of data from the analytical ultracentrifuge by nonlinear leastsquare techniques
41. Platelet receptor recognition domain on the gamma chain of human fibrinogen and its synthetic peptide analogues
42. Conformational changes: How small is big enough?
43. Implications of atomic-resolution structures for cell adhesion
44. Crystal structure of the A domain from the α subunit of integrin CR3 (CD11b/CD18)
45. Two conformations of the integrin A-domain (I-domain): A pathway for activation?
46. Bidirectional transmembrane modulation of integrin αIIbβ3 conformations
47. From crystal clear ligand binding to designer I domains
48. The structural basis of dynamic cell adhesion: Heads, tails, and allostery
49. New insights into integrin-ligand interaction
50. Purification of octyl beta-D-glucopyranoside and re-estimation of its micellar size
51. A transmembrane helix dimer: Structure and implications
52. Structural analysis of the KGD sequence loop of barbourin, an alpha(IIb)beta(3)-specific disintegrin
53. Elucidation of a common structure of selective fibrinogen receptor antagonists
54. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function
55. Integrin cytoplasmic domains mediate inside-out signal transduction
56. A piston model for transmembrane signaling of the aspartate receptor
57. Synthetic peptides derived from fibrinogen and fibronectin change the conformation of purified glycoprotein IIb-IIIa
58. A recombinant soluble form of the integrin αIIbβ3 (GpIIb-IIIa) Assumes an active, ligand-binding conformation and is recognized by gpIIb-IIIa specific monoclonal, allo-, auto-, and drug-dependent platelet antibodies
59. The platelet membrane glycoprotein IIb-IIIa complex
60. Clinical pharmacology of eptifibatide
61. Ligand binding to integrins
62. The effect of arg-gly-asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets
63. Structure of the platelet membrane glycoprotein IIb. Homology to the A subunits of the vitronectin and fibronectin membrane receptors
64. Inhibition of fibrin(ogen) binding to stimulated platelets by a monoclonal antibody specific for a conformational determinant of gpIIIa
65. 3 integrin solution conformation
66. New perspectives in cell adhesion: RGD and integrins
67. Competition for related but nonidentical binding sites on the glycoprotein IIb-IIIa complex by peptides derived from platelet adhesive proteins
68. Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri
69. Design of potent and specific integrin antagonists. Peptide antagonists with a high specificity for glycoprotein IIb-IIIa
70. Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms
71. Signaling through platelet integrin αIIbβ3: Inside-out, outside-in, and sideways
72. Integrin signaling: The platelet paradigm
73. Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex
74. BEAMS (BEAds Modeling System): A set of computer programs for the visualization and the computation of hydrodynamic and conformational properties of beads models of proteins
75. Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain
76. Boundary analysis in sedimentation transport experiments: A procedure for obtaining sedimentation coefficient distributions using the time derivative of the concentration profile
77. Ligand recognition by beta 3 integrins
78. Sodium dodecyl sulfate-stable complexes of echistatin and RGD-dependent integrins: A novel approach to study integrins
79. Alkyl glycoside detergents: Synthesis and applications to the study of membrane proteins
80. Carboxyl-terminal portions of the α chains of fibrinogen and fibrin. Localization by electron microscopy and the effects of isolated αC fragments on polymerization
81. A structural basis for integrin activation by the cytoplasmic tail of the αIIb-subunit
82. Structure of the fibrinogen gamma-chain integrin binding and factor XIIIa cross-linking sites obtained through carrier protein driven crystallization
83. Examination of the platelet membrane glycoprotein IIb-llIa complex and its interaction with fibrinogen and other ligands by electron microscopy
84. A model for fibrinogen: Domains and sequence
85. Hematopoietic receptor complexes
86. 3 subunit
87. A Redox site involved in integrin activation
88. Crystal structure of a 30 kDa C-terminal fragment from the gamma chain of human fibrinogen