Stabilizing the integrin αM inserted domain in alternative conformations with a range of engineered disulfide bonds

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 26, 2002, Pages 16737-16741

  Shimaoka, Motomu ^a   Lu, Chafen ^a   Salas, Azucena ^a   Xiao, Tsan ^a   Takagi, Junichi ^a   Springer, Timothy A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CD11b; Cell adhesion; Mac 1; Protein design; VWA domain

Indexed keywords

ALPHAM INTEGRIN; CYSTEINE; DIMER; DITHIOTHREITOL; INTEGRIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DISULFIDE BOND; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; STEREOCHEMISTRY;

DIMERIZATION; DISULFIDES; DITHIOTHREITOL; HUMANS; MACROPHAGE-1 ANTIGEN; PROTEIN CONFORMATION; PROTEIN ENGINEERING;

EID: 0037168524     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.252633099     Document Type: Article

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