Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity and expression of CYP3A2 and CYP2C11

European Journal of Pharmacology

Volumn 498, Issue 1-3, 2004, Pages 257-265

  Ueyama, Jun ^a   Kitaichi, Kiyoyuki ^a   Nadai, Masayuki ^b   Iwase, Mitsunori ^c   Tomyo, Nao ^a   Kanazawa, Hiroaki ^d   Suzuki, Ryujiro ^e   Takagi, Kenji ^a   Takagi, Kenzo ^a   Hasegawa, Takaaki ^a,f  

^a NAGOYA UNIVERSITY   (Japan)

^b MEIJO UNIVERSITY   (Japan)

^c TOYOTA MEMORIAL HOSPITAL   (Japan)

^d UNIVERSITY OF TOYAMA   (Japan)

^e NAGOYA UNIVERSITY HOSPITAL   (Japan)

^f AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

(Rat); Antipyrine clearance; CYP2C11; CYP3A2; Endotoxin; Pioglitazone; PPAR

Indexed keywords

CYTOCHROME P450 2C11; CYTOCHROME P450 3A2; ENDOTOXIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PHENAZONE; PIOGLITAZONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; IN VIVO STUDY; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT;

EID: 4444317289     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.07.079     Document Type: Article

References (55)

1. H. Ando, Y. Nishio, K. Ito, A. Nakao, L. Wang, Y.L. Zhao, K. Kitaichi, K. Takagi, and T. Hsegawa Effect of endotoxin on P-glycoprotein-mediated biliary and renal excretion of rhodamine-123 in rats Antimicrob. Agents Chemother. 45 2001 3462 3467
2. M.M. Arriero, J.A. Rodriguez-Feo, A. Celdran, L. Sanchez de Miguel, F. Gonzalez-Fernandez, J. Fortes, A. Reyero, O. Frieyro, J.C. de la Pinta, A. Franco, C. Pastor, S. Casado, and A. Lopez-Farre Expression of endothelial nitric oxide synthase in human peritoneal tissue: regulation by Escherichia coli lipopolysaccharide J. Am. Soc. Nephrol. 11 2000 1848 1856
3. T.B. Barclay, J.M. Peters, M.B. Sewer, L. Ferrari, F.J. Gonzalez, and E.T. Morgan Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor- α dependent J. Pharmacol. Exp. Ther. 290 1999 1250 1257
4. S.K. Balani, T. Zhu, J. Yang, Z. Liu, B. He, and F.W. Lee Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys Drug Metab. Dispos. 30 2002 1059 1062
5. A.P. Beigneux, A.H. Moser, J.K. Shigenaga, C. Grunfeld, and K.R. Feingold The acute phase response is associated with retinoid X receptor repression in rodent liver J. Biol. Chem. 27 2000 16390 16399
6. O. Braissant, F. Foufelle, C. Scotto, M. Dauca, and W. Wahli Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat Endocrinology 137 1996 354 366
7. J.A. Carcillo, L. Doughty, D. Kofos, R.F. Frye, S.S. Kaplan, H. Sasser, and G.J. Burckart Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure Intensive Care Med. 29 2003 980 984
8. T.J. Carlson, and R.E. Billings Role of nitric oxide in the cytokine-mediated regulation of cytochrome P-450 Mol. Pharmacol. 49 1996 796 801
9. M.A. Cassatella, L. Meda, S. Bonora, M. Ceska, and G. Constantin Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide J. Exp. Med. 178 1993 2207 2211
10. Y.L. Chen, I. Florentin, A.M. Batt, L. Ferrari, J.P. Giroud, and L. Chauvelot-Moachon Effects of interleukin-6 on cytochrome P450-dependent mixed-function oxidases in the rat Biochem. Pharmacol. 44 1992 137 148
11. E.K. Crawford, J.E. Ensor, I. Kalvakolanu, and J.D. Hasday The role of 3′ poly(A) tail metabolism in tumor necrosis factor-alpha regulation J. Biol. Chem. 272 1997 21120 21127
12. G. Engel, and J. Cosme Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine formation Clin. Pharmacol. Ther. 59 1996 613 622
13. T.J. Evans, E. Strivens, A. Carpenter, and J. Cohen Differences in cytokine response and induction of nitric oxide synthase in endotoxin-resistant and endotoxin-sensitive mice after intravenous gram-negative infection J. Immunol. 150 1993 5033 5040
14. H.D. Flad, H. Loppnow, E.T. Rietschel, and A.J. Uimer Agonists and antagonists for lipopolysaccharide-induced cytokines Immunobiology 187 1993 303 316
15. J.T.M. Frieling, J.A. Mulder, T. Hendriks, J.H.A. Curfs, C.J. Van der Linden, and R.W. Sauerwein Differential induction of pro- and anti-inflammatory cytokines in whole blood by bacteria: effects of antibiotic treatment Antimicrob. Agents Chemother. 41 1997 1439 1443
16. M.E. Greene, B. Blumberg, O.W. McBride, H.F. Yi, K. Kronquist, K. Kwan, L. Hsieh, G. Greene, and S.D. Nimer Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping Gene Expr. 4 1995 281 299
17. C. Jiang, A.T. Ting, and B. Seed PPARγ agonists inhibit production of monocyte inflammatory cytokines Nature 391 1998 82 86
18. K. Kitaichi, L. Wang, K. Takagi, M. Iwase, E. Shibata, M. Nadai, K. Takagi, and T. Hasegawa Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide Antimicrob. Agents Chemother. 43 1999 2697 2701
19. K. Kitaichi, H. Nakayama, J. Ueyama, M. Nadai, K. Baba, K. Takagi, K. Takagi, M. Ohta, and T. Hasegawa Down-regulation of cytochrome P450 proteins and its activities by Shiga-like toxin II from Escherichia coli O157:H7 Biochem. Pharmacol. 67 2004 1427 1435
20. M. Kockx, P.P. Gervois, P. Poulain, B. Derudas, J.M. Peters, F.J. Gonzalez, H.M. Princen, T. Kooistra, and B. Staels Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator- activated receptor-alpha Blood 93 1999 2991 2998
21. J.C. Kolars, K.S. Lown, R.P. Schmiedlin, M. Ghosh, C. Fang, S.A. Wrighton, R.M. Merion, and P.B. Watkins CYP3A gene expression in human gut epithelium Pharmacogenetics 4 1994 247 259
22. R.E. Law, S. Goetze, X.-P. Xi, S. Jackson, Y. Kawana, L. Demer, M.C. Fishbein, W.P. Meehan, and W.A. Hsueh Expression and function of PPARγ in rat and human vascular smooth muscle cells Circulation 101 2000 1311 1318
23. J.K. Lee, S.S. Choi, J.S. Won, and H.W. Suh The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells: involvement of AP-1 and NFkappaB Life Sci. 73 2003 595 609
24. J.M. Lehmann, L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Willson, and S.A. Kliewer An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma) J. Biol. Chem. 270 1995 12953 12956
25. G. Mathiak, K. Kabir, G. Grass, H. Keller, E. Steinringer, T. Minor, C. Rangger, and L.F. Neville Lipopolysaccharides from different bacterial sources elicit disparate cytokine responses in whole blood assays Int. J. Mol. Med. 11 2003 41 44
26. Y. Minamiyama, S. Takemura, S. Imaoka, Y. Funae, Y. Tanimoto, and M. Inoue Irreversible inhibition of cytochrome P450 by nitric oxide J. Pharmacol. Exp. Ther. 283 1998 1479 1485
27. M. Monshouwer, R.F. Witkamp, S.M. Nijmeijer, L.A. Van Leengoed, H.C. Vernooy, J.H. Verheijden, and A.S. Van Miert A lipopolysaccharide-induced acute phase response in the pig is associated with a decrease in hepatic cytochrome P450-mediated drug metabolism J. Vet. Pharmacol. Ther. 19 1996 382 388
28. ET. Morgan Down-regulation of multiple cytochrome P450 gene products by inflammatory mediators in vivo. Independence from the hypothalamo†"pituitary axis Biochem. Pharmacol. 45 1993 415 419
29. E.T. Morgan Regulation of cytochrome P450 during inflammation and infection Drug Metab. Rev. 29 1997 1129 1188
30. E.T. Morgan Regulation of cytochrome P450 by inflammatory mediators: why and how? Drug Metab. Dispos. 29 2001 207 215
31. E.T. Morgan, K.B. Thomas, R. Swanson, T. Vales, J. Hwang, and K. Wright Selective suppression of cytochrome P-450 gene expression by interleukins 1 and 6 in rat liver Biochim. Biophys. Acta 1219 1994 475 483
32. M. Nadai, I. Matsuda, L. Wang, A. Itoh, K. Naruhashi, T. Nabeshima, M. Asai, and T. Hasegawa Granulocyte colony-stimulating factor enhances endotoxin-induced decrease in biliary excretion of the antibiotic cefoperazone in rats Antimicrob. Agents Chemother. 42 1998 2178 2183
33. M. Nadai, T. Sekido, I. Matsuda, L. Wang, K. Kitaichi, A. Itoh, T. Nabeshima, and T. Hasegawa Time-dependent effects of Klebsiella pneumoniae endotoxin on hepatic drug-metabolizing enzyme activity in rats J. Pharm. Pharmacol. 50 1998 871 879
34. L. Nadin, A.M. Butler, G.C. Farrell, and M. Murray Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis factor alpha Gastroenterology 109 1995 198 205
35. M.G. Netea, B.J. Kullberg, L.A.B. Joosten, T. Sprong, I. Verschueren, O.C. Boerman, F. Amiot, W.B. van den Berg, and J.W.M. Van der Meer Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathways Eur. J. Immunol. 31 2001 2529 2538
36. S.N. Nowak, D.J. Edwards, A. Clarke, G.D. Anderson, and L.A. Jaber Pioglitazone: effect on CYP3A4 activity J. Clin. Pharmacol. 42 2002 1299 1302
37. T. Omura, and R. Sato The carbon monoxide-binding pigment of liver microsomes J. Biol. Chem. 237 1964 2370 2378
38. C. Pous, J.P. Giroud, C. Damais, D. Raichvarg, and L. Chauvelot-Moachon Effect of recombinant human interleukin-1 beta and tumor necrosis factor alpha on liver cytochrome P-450 and serum alpha-1-acid glycoprotein concentrations in the rat Drug Metab. Dispos. 18 1990 467 470
39. 2 inhibition of mesangial cell iNOS expression Clin. Immunol. 98 2001 337 345
40. M. Ricote, A.C. Li, T.M. Willson, C.J. Kelly, and C.K. Glass The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation Nature 391 1998 79 82
41. A.L. Roe, G. Warren, G. Hou, G. Howard, S.I. Shedlofsky, and R.A. Blouin The effect of high dose endotoxin on CYP3A2 expression in the rat Pharm. Res. 15 1998 1603 1608
42. J. Sakamoto, H. Kimura, S. Moriyama, H. Odaka, Y. Momose, Y. Sugiyama, and H. Sawada Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone Biochem. Biophys. Res. Commun. 278 2000 704 711
43. A. Sauer, T. Hartung, J. Aigner, and A. Wendel Endotoxin-inducible granulocyte-mediated hepatocytotoxicity requires adhesion and serine protease release J. Leukoc. Biol. 60 1996 633 643
44. U. Savas, K.J. Griffin, and E.F. Johnson Molecular mechanisms of cytochrome P-450 induction by xenobiotics: an expanded role for nuclear hormone receptors Mol. Pharmacol. 56 1999 851 857
45. M.B. Sewer, and E.T. Morgan Nitric oxide-independent suppression of P450 2C11 expression by interleukin-1beta and endotoxin in primary rat hepatocytes Biochem. Pharmacol. 54 1997 729 737
46. M.B. Sewer, and E.T. Morgan Down-regulation of the expression of three major rat liver cytochrome P450s by endotoxin in vivo occurs independently of nitric oxide production J. Pharmacol. Exp. Ther. 287 1998 352 358
47. M.B. Sewer, D.R. Koop, and E.T. Morgan Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450 Drug Metab. Dispos. 24 1996 401 407
48. M.B. Sewer, T.B. Barclay, and E.T. Morgan Down-regulation of cytochrome P450 mRNAs and proteins in mice lacking a functional NOS2 gene Mol. Pharmacol. 54 1998 273 279
49. P. Souček, and I. Gut Cytochromes P-450 in rats: structures, functions, properties and relevant human forms Xenobiotica 22 1992 83 103
50. S. Takemura, Y. Minamiyama, S. Imaoka, Y. Fumie, K. Hirohashi, M. Inoue, and H. Kinoshita Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia J. Hepatol. 30 1999 1035 1044
51. K. Uchimura, M. Nkamura, M. Enjoji, T. Irie, R. Sugimoto, T. Muta, H. Iwamoto, and H. Nawata Activation of retinoic X receptor and peroxisome proliferator-activated receptor-γ inhibits nitric oxide and tumor necrosis factor-α production in rat Kupffer cells Hepatology 33 2001 91 99
52. G.W. Warren, S.M. Poloyac, D.S. Gary, M.P. Mattson, and R.A. Blouin Hepatic cytochrome P-450 expression in tumor necrosis factor-alpha receptor (p55/p75) knockout mice after endotoxin administration J. Pharmacol. Exp. Ther. 288 1999 945 950
53. T.M. Willson, J.E. Cobb, D.J. Cowean, R.W. Wiethe, I.D. Correa, S.R. Prakash, K.D. Beck, L.B. Moore, S.A. Kliewer, and J.M. Lehmann The structureâ€"activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones J. Med. Chem. 39 1996 665 668
54. H. Yamazaki, M. Suzuki, K. Tane, N. Shimada, M. Nakajima, and T. Yokoi In vitro inhibitory effects of troglitazone and its metabolites on drug oxidation activities of human cytochrome P450 enzymes: comparison with pioglitazone and rosiglitazone Xenobiotica 30 2000 61 70
55. YL. Zhao, X.B. Cen, M. Ito, K. Yokoyama, K. Takagi, K. Kitaichi, M. Nadai, M. Ohta, K. Takagi, and T. Hasegawa Shiga-like toxin II derived from Escherichia coli O157:H7 modifies renal handling of levofloxacin in rats Antimicrob. Agents Chemother. 46 2002 1522 1528