Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models

Journal of Neuroscience Research

Volumn 77, Issue 5, 2004, Pages 681-689

  Ortiz, E ^a   Pasquini, J M ^a   Thompson, K ^b   Felt, B ^c   Butkus, G ^d   Beard, J ^e   Connor, James R ^d  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d PENN STATE COLLEGE OF MEDICINE   (United States)

^e PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Brain iron content; Iron storage; Iron transport; Myelin composition

Indexed keywords

APOTRANSFERRIN; IRON; LIPID; MYELIN; MYELIN PROTEIN; PROTEOLIPID PROTEIN; TRANSFERRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN LEVEL; CONTROLLED STUDY; FEMALE; IRON BALANCE; IRON DEFICIENCY; IRON INTAKE; IRON KINETICS; IRON METABOLISM; IRON STORAGE; IRON TRANSPORT; MOUSE; MYELIN DEFICIENCY; MYELINATION; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PERINATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

ANIMALS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; DIET; FATTY ACIDS; FEMALE; FERRITINS; IRON; MALE; MICE; MICE, NEUROLOGIC MUTANTS; MICE, TRANSGENIC; MODELS, ANIMAL; MYELIN PROTEINS; MYELIN SHEATH; OLIGODENDROGLIA; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; TRANSFERRIN;

EID: 4444273210     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20207     Document Type: Article

References (68)

1. Aisen P, Enns C, Wessling-Resnick M. 2001. Chemistry and biology of eukaryotic iron metabolism. Int J Biochem Cell Biol 33:940-959.
2. Algarin C, Peirano P, Garrido M, Pizarro F, Lozoff B. 2003. Iron deficiency anemia in infancy: long-lasting effects on auditory and visual system functioning. Pediatr Res 53:217-223.
3. Atkinson S, Li YQ, Wong CS. 2003. Changes in oligodendrocytes and myelin gene expression after radiation in the rodent spinal cord. Int J Radiat Oncol Biol Phys 57:1093-1100.
4. Barbarese E, Carson JH, Braun PE. 1978. Accumulation of the four myelin basic proteins in mouse brain during development. J Neurochem 31:779-782.
5. Bartlett WP, Li XS, Connor JR. 1991. Expression of transferrin mRNA in the CNS of normal and jimpy mice. J Neurochem 57:318-322.
6. Baynes RD. 1996. Assessment of iron status. Clin Biochem 29:209-215.
7. Beard J. 2003. Iron deficiency alters brain development and functioning. J Nutr 133:14685-14725.
8. Beard JL, Connor JR. 2003. Iron status and neural functioning. Annu Rev Nutr 23:41-58.
9. Beard J, Wiesinger J, Connor J. 2003. Pre- and postweaning iron deficiency alters myelination in Sprague-Dawley rats. Dev Neurosci 25:308-315.
10. Bernstein SE. 1987. Hereditary hypotransferrinemia with hemosiderosis, a murine disorder resembling human atransferrinemia. J Lab Clin Med 110:690-705.
11. Buys SS, Martin CB, Eldridge M, Kushner JP, Kaplan J. 1991. Iron absorption in hypotransferrinemic mice. Blood 78:3288-3290.
12. Cammer W. 1984. Oligodendrocyte associated enzymes. In: Norton WT, editor. Oligodendroglia. New York: Plenum Press, p 199-232.
13. Cheepsunthorn P, Palmer C, Connor JR. 1998. Cellular distribution of ferritin subunits in postnatal rat brain. J Comp Neurol 400:73-86.
14. Chen PS Jr, Toribara T. 1956. Microdetermination of phosphorus. Anal Chem 28:1756-1758.
15. Connor JR, Menzies SL. 1990. Altered cellular distribution of iron in the CNS of myelin deficient rats. Neuroscience 34:265-271.
16. Connor JR, Menzies SL. 1996. Relationship of iron to oligodendrocytes and myelination. Glia 17:83-93.
17. Connor JR, Phillips TM, Lakshman MR, Barron KD, Fine RE, Csiza CK. 1987. Regional variation in the levels of transferrin in the CNS of normal and myelin-deficient rats. J Neurochem 49:1523-1529.
18. Connor JR, Menzies SL, Roskains AJ, Williams ME. 1993. Transferrin and iron in the shiverer mouse brain. J Neurosci Res 36:501-507.
19. Connor JR, Pavlick G, Karli D, Menzies SL, Palmer C. 1995. A histochemical study of iron-positive cells in the developing rat brain. J Comp Neurol 355:111-123.
20. Cook JD, Skikne BS, Baynes RD. 1994. Iron deficiency: the global perspective. Adv Exp Med Biol 356:219-228.
21. Cozzi A, Levi S, Corsi B, Santambrogio P, Campanella A, Gerardi G, Arosio P. 2003. Role of iron and ferritin in TNFalpha-induced apoptosis in HeLa cells. FEBS Lett 537:187-192.
22. Crowe A, Morgan EH. 1992. Iron and transferrin uptake by brain and cerebrospinal fluid in the rat. Brain Res 592:8-16.
23. de Arriba Zerpa GA, Saleh MC, Fernandez PM, Guillou F, Espinosa de los Monteros A, de Vellis J, Zakin MM, Baron B. 2000. Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line. J Neurosci Res 61:388-395.
24. Deregnier R, Nelson C, Thomas K, Wewerka S, Georgieff M. 2000. Neurophysiologic evaluation of auditory recognition memory in healthy newborn infants and infants of diabetic mothers. J Pediatr 137:777-784.
25. Dickinson TK, Connor JR. 1994. Histological analysis of selected brain regions of hypotransferrinemic mice. Brain Res 635:169-178.
26. Dickinson TK, Connor JR. 1995. Cellular distribution of iron, transferrin, and ferritin in the hypotransferrinemic (Hp) mouse brain. J Comp Neurol 355:67-80.
27. Dickinson TK, Connor JR. 1998. Immunohistochemical analysis of transferrin receptor: regional and cellular distribution in the hypotransferrinemic (hpx) mouse brain. Brain Res 801:171-181.
28. Escobar Cabrera OE, Bongarzone ER, Soto EF, Pasquini JM. 1994. Single intracerebral injection of apotransferrin in young rats induces increased myelination. Dev Neurosci 16:248-254.
29. Escobar Cabrera OE, Soto EF, Pasquini JM. 2000. Myelin membranes isolated from rats intracranially injected with apotransferrin are more susceptible to in vitro peroxidation. Neurochem Res 25:87-93.
30. Espinosa de los Monteros A, Kumar S, Zhao P, Huang CJ, Nazarian R, Pan T, Scully S, Chang R, de Vellis J. 1999. Transferrin is an essential factor for myelination. Neurochem Res 24:235-248.
31. Espinosa-Jeffrey A, Kumar S, Zhao PM, Awosika O, Agbo C, Huang A, Chang R, De Vellis J. 2002. Transferrin regulates transcription of the MBP gene and its action synergizes with IGF-1 to enhance myelinogenesis in the md rat. Dev Neurosci 24:227-241.
32. Folch PJ, Lees M, Sloane-Stanley G. 1957. A simple method for isolation and purification of total lipids from animal tissues. J Biol Chem 226:499-509.
33. Gocht A, Keith AB, Candy JM, Morris CM. 1993. Iron uptake in the brain of the myelin deficient rat. Neurosci Lett 154:187-190.
34. Greer JM, Lees MB. 2002. Myelin proteolipid protein - the first 50 years. Int J Biochem Cell Biol 34:211-215.
35. Han J, Day JR, Connor JR, Beard JL. 2003. Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats. Nutr Neurosci 6:1-10.
36. Hess HH, Lewin E. 1965. Microassay of biochemical structural components in nervous tissue II. Method for cerebrosides, proteolipid proteins and residue proteins. J Neurochem 12:205-211.
37. Hulet SW, Powers S, Connor JR. 1999a. Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains. J Neurol Sci 165:48-55.
38. Hulet SW, Hess EJ, Debinski W, Arosio P, Bruce K, Powers S, Connor JR. 1999b. Characterization and distribution of ferritin binding sites in the adult mouse brain. J Neurochem 72:868-874.
39. Hulet SW, Heyliger SO, Powers S, Connor JR. 2000. Oligodendrocyte progenitor cells internalize ferritin via clathrin-dependent receptor mediated endocytosis. J Neurosci Res 61:52-60.
40. Hulet SW, Menzies S, Connor JR. 2002. Ferritin binding in the developing mouse brain follows a pattern similar to myelination and is unaffected by the jimpy mutation. Dev Neurosci 24:208-213.
41. Kwik-Uribe C, Gietzen D, German J, Golub M, Keen C. 2000. Chronic marginal iron intake during early development in mice results in persistent changes in dopamine metabolism and myelin composition. J Nutr 130: 2821-2830.
42. Lapetina E, Soto E, De Robertis E. 1968. Lipids and proteolipids in isolated subcellular membranes of rat brain cortex. J Neurochem 15:437-445.
43. Larkin E, Rao G. 1990. Importance of fetal and neonatal iron: Adequacy for normal development of central nervous system. In: Dobbing J, editor. Brain, behaviour and iron in the infant diet. London: Springer-Verlag, p 43-63.
44. Lees MB, Paxman S. 1972. Modification of the Lowry procedure for the analysis of proteolipid proteins. Anal Biochem 47:184-192.
45. LeVine SM. 1991. Oligodendrocytes and myelin sheaths in normal, quaking and shiverer brains are enriched in iron. J Neurosci Res 29:413-419.
46. LeVine SM, Macklin WB. 1990. Iron-enriched oligodendrocytes: a reexamination of their spatial distribution. J Neurosci Res 26:508-512.
47. Lin HH, Connor JR. 1989. The development of the transferrin-transferrin receptor system in relation to astrocytes, MBP and galactocerebroside in normal and myelin-deficient rat optic nerves. Brain Res Dev Brain Res 49:281-293.
48. Lozoff B, Brittenham GM, Wolf AW. McClish DK, Kuhnert PM, Jimenez E, Jimenez R, Mora LA, Gomez I, Krauskoph D. 1987. Iron deficiency anemia and iron therapy effects on infant developmental test performance. Pediatrics 79:981-995.
49. Marta CB, Ortiz EH, Hallak M, Baron B, Guillou F, Zakin MM, Soto EF, Pasquini JM. 2002. Changes in the expression of cytoskeletal proteins in the CNS of transferrin transgenic mice. Dev Neurosci 24:242-251.
50. Marta C, Paez P, Lopez M, Pellegrino de Iraldi A, Soto EF, Pasquini JM. 2003. Morphological changes of myelin sheats in rats intracranially injected with apotransferrin. Neurochem Res 28:101-110.
51. Mayer-Proschel M, Morath DJ. 2002. Iron deficiency during embryogenesis and consequences for oligodendrocyte generation in vivo. Dev Neurosci 24:197-207.
52. Norton WT, Poduslo S. 1973. Myelination in rat brain: method of myelin isolation. J Neurochem 21:749-757.
53. Okayasu T. 1981. Purification and characterization of linoleoyl-CoA desaturase from rat liver microsomes [author's translation]. Hokkaido Igaku Zasshi 56:43-54.
54. Oloyede OB, Folayan AT, Odutuga AA. 1992. Effects of low-iron status and deficiency of essential fatty acids on some biochemical constituents of rat brain. Biochem Int 27:913-922.
55. Pleasure D, Kim SU, Silberberg DH. 1984. In vitro studies of oligodendroglial lipid metabolism. In: Norton W, editor. Oliogodenroglia. New York: Plenum Press, p 175-198.
56. Qi Y, Dawson G. 1994. Hypoxia specifically and reversibly induces the synthesis of ferritin in oligodendrocytes and human oligodendrogliomas. J Neurochem 63:1485-1490.
57. Qi Y, Jamindar TM, Dawson G. 1995. Hypoxia alters iron homeostasis and induces ferritin synthesis in oligodendrocytes. J Neurochem 64:2458-2464.
58. Rao PS. 1979. Fatty acid composition of cerebrosides and phospholipids in brains of undernourished rats. Nutr Metab 23:136-144.
59. Rao R, Tkae I, Townsend E, Gruetter R, Georgieff M. 2003. Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus. J Nutr 133:3215-3221.
60. Saleh MC, Espinosa de los Monteros A, de Arriba Zerpa GA, Fontaine I, Piaud O, Djordjijevic D, Baroukh N, Garcia Otin AL, Ortiz E, Lewis S, Fiette L, Santambrogio P, Belzung C, Connor JR, de Vellis J, Pasquini JM, Zakin MM, Baron B, Guillou F. 2003. Myelination and motor coordination are increased in transferrin transgenic mice. J Neurosci Res 72:587-594.
61. Sanyal B, Polak PE, Szuchet S. 1996. Differential expression of the heavy-chain ferritin gene in non-adhered and adhered oligodendrocytes. J Neurosci Res 46:187-197.
62. Searcy R, Bergquist LM. 1960. A new color reaction for the quantitation of serum cholesterol. Clin Chim Acta 5:192-199.
63. Stangl GI, Kirchgessner M. 1998. Different degrees of moderate iron deficiency modulate lipid metabolism of rats. Lipids 33:889-895.
64. Staugaitis SM, Colman DR, Pedraza L. 1996. Membrane adhesion and other functions for the myelin basic proteins. Bioessays 18:13-18.
65. Strittmatter P, Enoch HG. 1978. Purification of stearyl-CoA desaturase from liver. Methods Enzymol 52:188-193.
66. Takeda A, Devenyi A, Connor JR. 1998. Evidence for non-transferrin- mediated uptake and release of iron and manganese in glial cell cultures from hypotransferrinemic mice. J Neurosci Res 51:454-462.
67. Thompson K, Menzies S, Muckenthaler M, Torti FM, Wood T, Torti SV, Hentze MW, Beard J, Connor J. 2003. Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress. J Neurosci Res 71:46-63.
68. Wagner-Recio M, Toews AD, Morell P. 1991. Tellurium blocks cholersterol synthesis by inhibiting squlaene metabolism: preferential vulnerability to this metabolic block leads to peripheral nervous system demyelination. J Neurochemistry 57:1891.