Changes in oligodendrocytes and myelin gene expression after radiation in the rodent spinal cord

International Journal of Radiation Oncology Biology Physics

Volumn 57, Issue 4, 2003, Pages 1093-1100

  Atkinson, Shelley ^a,b   Li, Yu Qing ^b   Wong, C Shun ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

CNS; Demyelination; Myelin gene expression; Oligodendrocytes; Radiation injury

Indexed keywords

GENES; IRRADIATION; ONCOLOGY;

GENE EXPRESSION;

RADIOTHERAPY;

BETA GALACTOSIDASE; FAST BLUE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; LUXOL FAST BLUE; MYELIN; PROTEOLIPID PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DENSITY; CELL LINEAGE; CERVICAL SPINAL CORD; COLON POLYPOSIS; CONTROLLED STUDY; DEMYELINATION; DISEASE MODEL; DOSE TIME EFFECT RELATION; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION; RADIATION DOSE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

EID: 0142248779     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(03)00735-1     Document Type: Article

References (33)

1. Schultheiss T.E., Kun L.E., Ang K.K., et al. Radiation response of the central nervous system. Int J Radiat Oncol Biol Phys. 31:1995;1093-1112.
2. Tofilon P.J., Fike J.R. The radioresponse of the central nervous system A dynamic process. Radiat Res. 153:2000;357-370.
3. Franklin R.J.M. Why does remyelination fail in multiple sclerosis? Nat Rev Neurosci. 3:2002;705-714.
4. Gensert J.M., Goldman J.E. Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron. 19:1997;197-203.
5. Ffrench-Constant C., Raff M.C. Proliferating bipotential glial progenitor cells in adult rat optic nerve. Nature. 319:1986;499-502.
6. McTigue D.M., Wei P., Stokes B.T. Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord. J Neurosci. 21:2001;3392-3400.
7. Chari D.M., Blakemore W.F. Efficient recolonization of progenitor-depleted areas of the CNS by adult oligodendrocyte progenitor cells. Glia. 37:2002;307-313.
8. Redwine J.M., Armstrong R.C. In vivo proliferation of oligodendrocyte progenitors expressing PDGF-alphaR during early remyelination. J Neurobiol. 37:1998;413-428.
9. Levine J.M., Reynolds R. Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination. Exp Neurol. 160:1999;333-347.
10. Keirstead H.S., Levine J.M., Blakemore W.F. Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord. Glia. 22:1998;161-170.
11. Vrdoljak E., Bill C.A., Stephens L.C., et al. Radiation-induced apoptosis of oligodendrocytes in vitro. Int J Radiat Biol. 62:1992;475-480.
12. Li Y.Q., Guo Y.P., Jay V., et al. Time course of radiation-induced apoptosis in the adult rat spinal cord. Radiother Oncol. 39:1996;35-42.
13. Li Y.Q., Jay V., Wong C.S. Oligodendrocytes in the adult rat spinal cord undergo radiation-induced apoptosis. Cancer Res. 56:1996;5417-5422.
14. Kurita H., Kawahara N., Asai A., et al. Radiation-induced apoptosis of oligodendrocytes in the adult rat brain. Neurol Res. 23:2001;869-874.
15. Chow B.M., Li Y.Q., Wong C.S. Radiation-induced apoptosis in the adult central nervous system is p53-dependent. Cell Death Differ. 7:2000;712-720.
16. Mastaglia F.L., McDonald W.I., Watson J.V., et al. Effects of x-radiation on the spinal cord An experimental study of the morphological changes in central nerve fibres. Brain. 99:1976;101-122.
17. Chiang C.-S., McBride W.H., Withers H.R. Myelin-associated changes in mouse brain following irradiation. Radiother Oncol. 27:1993;229-236.
18. Chiang C.S., Mason K.A., Withers H.R., et al. Alteration in myelin-associated proteins following spinal cord irradiation in guinea pigs. Int J Radiat Oncol Biol Phys. 24:1992;929-937.
19. Wong C.S., Minkin S., Hill R.P. Linear-quadratic model underestimates sparing effect of small doses per fraction in rat spinal cord. Radiother Oncol. 23:1992;176-184.
20. Chandross K.J., Cohen R.I., Paras P.J., et al. Identification and characterization of early glial progenitors using a transgenic selection strategy. J Neurosci. 19:1999;759-774.
21. Bhat R.V., Axt K.J., Fosnaugh J.S., et al. Expression of the APC tumor suppressor protein in oligodendroglia. Glia. 17:1996;169-174.
22. Fanarraga M.L., Dickinson P.J., Sommer I., et al. Evidence that some oligodendrocyte progenitors in the developing optic pathway express the plp gene. Glia. 18:1996;282-292.
23. Griffiths I., Klugmann M., Anderson T., et al. Current concepts of PLP and its role in the nervous system. Microsc Res Tech. 41:1998;344-358.
24. Hornsey S., Myers R., Coultas P.G., et al. Turnover of proliferative cells in the spinal cord after X irradiation and its relation to time-dependent repair of radiation damage. Br J Radiol. 54:1981;1081-1085.
25. Horner P.J., Power A.E., Kempermann G., et al. Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J Neurosci. 20:2000;2218-2228.
26. Watanabe M., Toyama Y., Nishiyama A. Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion. J Neurosci Res. 69:2002;826-836.
27. Hubbard B.M., Hopewell J.W. Changes in the neuroglial cell populations of the rat spinal cord after local X-irradiation. Br J Radiol. 52:1979;816-821.
28. Sheline G.E., Wara W.M., Smith V. Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys. 6:1980;1215-1228.
29. Shapira R., Mobley W.C., Thiele S.B., et al. Localization of 2′, 3′-cyclic nucleotide-3′-phosphohydrolase of rabbit brain by sedimentation in a continuous sucrose gradient. J Neurochem. 30:1978;735-744.
30. Woodruff R.H., Franklin R.J.M. The expression of myelin protein mRNAs during remyelination of lysolecithin-induced demyelination. Neuropathol Appl Neurobiol. 25:1999;226-235.
31. Morell P., Barrett C.V., Mason J.L., et al. Gene expression in brain during cuprizone-induced demyelination and remyelination. Mol Cell Neurosci. 12:1998;220-227.
32. Jurevics H., Largent C., Hostettler J., et al. Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination. J Neurochem. 82:2002;126-136.
33. Wrathall J.R., Li W., Hudson L.D. Myelin gene expression after experimental contusive spinal cord injury. J Neurosci. 18:1998;8780-8793.