Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat sertoli cells

Biology of Reproduction

Volumn 78, Issue 6, 2008, Pages 1139-1152

  Tash, Joseph S ^a,b   Chakrasali, Ramappa ^c   Jakkaraj, Sudhakar R ^c   Hughes, Jennifer ^a   Smith, S Kendall ^a,b   Hornbaker, Kaori ^a   Heckert, Leslie L ^a,b   Ozturk, Sedide B ^d   Hadden, M Kyle ^c   Kinzy, Terri Goss ^b,d   Blagg, Brian S J ^b,c   Georg, Gunda I ^b,c,e  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c UNIVERSITY OF KANSAS   (United States)

^d RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Fertilization; Male contraception; Sertoli cells; Spermatogenesis; Testis

Indexed keywords

ANTISPERMATOGENIC AGENT; ELONGATION FACTOR 1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GAMENDAZOLE; GELDANAMYCIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 82; HEAT SHOCK PROTEIN 90; I KAPPA B KINASE ALPHA; INTERLEUKIN 1ALPHA; NOVOBIOCIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EEF1 A1;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG TARGETING; GENETIC TRANSCRIPTION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SACCHAROMYCES CEREVISIAE; SERTOLI CELL; SPERMATOGENESIS; WESTERN BLOTTING;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; CELL LINE, TUMOR; FEMALE; HSP90 HEAT-SHOCK PROTEINS; INDAZOLES; INTERLEUKIN-1ALPHA; MALE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; OVARIAN NEOPLASMS; PEPTIDE ELONGATION FACTOR 1; RATS; SERTOLI CELLS; SPERMATOGENESIS-BLOCKING AGENTS; TESTIS; TRANSCRIPTION, GENETIC;

EUKARYOTA; MAMMALIA; RATTUS; SACCHAROMYCES CEREVISIAE;

EID: 44349149846     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.107.062679     Document Type: Article

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