A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose

Biology of Reproduction

Volumn 78, Issue 6, 2008, Pages 1127-1138

  Tash, Joseph S ^a,b   Attardi, Barbara ^c   Hild, Sheri A ^c   Chakrasali, Ramappa ^d   Jakkaraj, Sudhakar R ^d   Georg, Gunda I ^b,d,e  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c BIOQUAL INC   (United States)

^d UNIVERSITY OF KANSAS   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Fertilization; Male contraception; Sertoli cells; Spermatogenesis; Testis

Indexed keywords

AF 2364; AF 2785; ANTISPERMATOGENIC AGENT; FOLLITROPIN; GAMENDAZOLE; INHIBIN B; LONIDAMINE;

ABNORMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTRACEPTION; CONTROLLED STUDY; DRUG MEGADOSE; DRUG RESEARCH; FEMALE; FOLLITROPIN BLOOD LEVEL; HISTOPATHOLOGY; HORMONE INHIBITION; INFERTILITY; LETHARGY; LOW DRUG DOSE; MALE; MATING; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; SERTOLI CELL; SPERMATOGENESIS; TESTIS WEIGHT;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; FEMALE; FERTILITY; FOLLICLE STIMULATING HORMONE; GENITALIA, MALE; HYDRAZINES; INDAZOLES; INHIBINS; MALE; ORGAN SIZE; PREGNANCY; RATS; RATS, LONG-EVANS; SPERMATOGENESIS; SPERMATOGENESIS-BLOCKING AGENTS; TESTIS; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 44349123956     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.106.057810     Document Type: Article

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