Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids

Contraception

Volumn 65, Issue 4, 2002, Pages 277-278

  Gatto, Maria Teresa ^a   Tita, Beatrice ^a   Artico, Marco ^a   Saso, Luciano ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Antispermatogenic drugs; Indazole carboxylic acids; Lonidamine; Mechanism of action; Testicular and epididymal macroglobulins

Indexed keywords

ALPHA 2 MACROGLOBULIN; ALPHA1 PROTEINASE INHIBITOR III; CHLORIDE CHANNEL; HEXOKINASE; LONIDAMINE; MACROGLOBULIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CELL JUNCTION; CONTRACEPTION; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG TOLERABILITY; ENZYME INHIBITION; EPIDIDYMIS; GERM CELL; MITOCHONDRIAL ENERGY TRANSFER; NONHUMAN; SERTOLI CELL; SHORT SURVEY; TESTIS;

EID: 0036109010     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0010-7824(02)00289-5     Document Type: Article

References (21)

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4. Modulating effect of lonidamine on response to doxorubicin in metastatic breast cancer patients: Results from a multicenter prospective randomized trial
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6. Lonidamine in metastatic breast cancer
7. Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria
8. The role of mitochondrial hexokinase in neoplastic phenotype and its sensitivity to lonidamine
9. Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
10. Mitochondrion as a novel target of anticancer chemotherapy
11. Morphological and biochemical modifications of rat germ cell mitochondria induced by new antispermatogenic compounds: Studies in vivo and in vitro
12. Lonidamine and analogue AF2785 block the cyclic adenosine 3′,5′-monophosphate-activated chloride current and chloride secretion in the rat epididymis
13. Testin is tightly associated with testicular cell membrane upon its secretion by Sertoli cells whose steady-state mRNA level in the testis correlates with the turnover and integrity of inter-testicular cell junctions
14. Testin induction: The role of cyclic 3′,5′-adenosine monophosphate/protein kinase A signaling in the regulation of basal and lonidamine-induced testin expression by rat Sertoli cells
15. Effects of lonidamine on testicular and epididymal proteins in the rat
16. 2-Macroglobulin is not an acute-phase protein in the rat testis
17. Analysis of lonidamine in rat serum and testis by high-performance liquid chromatography (HPLC)
18. A comparative study of serum and testicular concentrations of AF 1312/TS (or 1-[(4-chlorophenyl) methyl] 1H-indazole-3-carboxylic acid) and diclondazolic acid (or 1-[(2,4-dichlorophenyl)methyl)] -1H-indazole-3-carboxylic acid) in rats
19. HPLC of lonidamine in human plasma and urine
20. An on-line semi-automated solid-phase extraction procedure for high-performance liquid chromatographic determination of lonida- mine in serum
21. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis