Indazole carboxylic acids in male contraception

Contraception

Volumn 65, Issue 4, 2002, Pages 265-268

  Cheng, C Yan ^a   Mo, Meng Yun ^a   Grima, Josephine ^a   Saso, Luciano ^b   Tita, Beatrice ^b   Mruk, Dolores ^a   Silvestrini, Bruno ^b  

^a POPULATION COUNCIL   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Adherens junctions; Germ cell loss; Male contraception; Sertoli cells; Testis

Indexed keywords

1 (2,4 DICHLOROBENZYL)INDAZOLE 3 ACRYLIC ACID; 1 (2,4 DICHLOROBENZYL)INDAZOLE 3 CARBOHYDRAZIDE; AF 2364; AF 2785; CARBOXYLIC ACID DERIVATIVE; INDAZOLE DERIVATIVE; MALE CONTRACEPTIVE AGENT; UNCLASSIFIED DRUG;

CELL ADHESION; CELL JUNCTION; CELL LOSS; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG SYNTHESIS; GERM CELL; HYPOTHALAMUS HYPOPHYSIS SYSTEM; NONHUMAN; ORAL CONTRACEPTION; REVIEW; SEMINIFEROUS TUBULE EPITHELIUM; SERTOLI CELL; SPERMATOGENESIS; TESTIS;

EID: 0036104071     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0010-7824(01)00318-3     Document Type: Article

References (17)

1. The cytology of the testis
2. The cell biology of the Sertoli cell
3. Status of male contraception: Hormonal approach
4. Testins are structurally related Sertoli cell proteins whose secretion is tightly coupled to the presence of germ cells
5. Testins are structurally related to the mouse cysteine proteinase precursor but devoid of any protease/anti-protease activity
6. Testin is tightly associated with testicular cell membrane upon its secretion by Sertoli cells whose steady-state mRNA level in the testis correlates with the turnover and integrity of inter-testicular cell junctions
7. Testin secreted by Sertoli cells is associated with the cell surface and its expression correlates with the disruption of Sertoli-germ cell junctions but not the inter-Sertoli tight junction
8. Germ cell control of testin production is inverse to that of other Sertoli cell products
9. Testin induction: The role of cyclic 3′,5′-adenosine monophosphate/protein kinase A signaling in the regulation of basal and lonidamine-induced testin expression by rat Sertoli cells
10. Identification of two testosterone-responsive testicular proteins in Sertoli cell-enriched culture medium whose secretion is suppressed by cells of the intact seminiferous tubule
11. 2-macroglobulin, and testins: Biosynthesis and differential regulation by germ cells
12. Immunohistochemical localization of testin in the female reproductive system of the rat is consistent with its involvement in the turnover of specialized junctional complexes
13. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis
14. Lonidamine and related compounds
15. Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide
16. Lonidamine and analogue AF2785 block the cyclic adenosine 3′,5′-monophosphate-activated chloride current and chloride secretion in the rat epididymis