메뉴 건너뛰기




Volumn 10, Issue 9, 2004, Pages 445-451

CDKs: Taking on a role as mediators of dopaminergic loss in Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; ISOENZYME;

EID: 4444285321     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2004.07.003     Document Type: Review
Times cited : (37)

References (70)
  • 1
    • 0033724826 scopus 로고    scopus 로고
    • Pathophysiology of the basal ganglia in Parkinson's disease
    • J.A. Obeso Pathophysiology of the basal ganglia in Parkinson's disease Trends Neurosci. 23 2000 S8 19
    • (2000) Trends Neurosci. , vol.23
    • Obeso, J.A.1
  • 2
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • W. Dauer, and S. Przedborski Parkinson's disease: mechanisms and models Neuron 39 2003 889 909
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 3
    • 0142062102 scopus 로고    scopus 로고
    • Familial Parkinson's disease: A hint to elucidate the mechanisms of nigral degeneration
    • N. Hattori Familial Parkinson's disease: a hint to elucidate the mechanisms of nigral degeneration J. Neurol. 250 Suppl. 3 2003 III2 II10
    • (2003) J. Neurol. , vol.250 , Issue.3
    • Hattori, N.1
  • 4
    • 1242274335 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum
    • K. Chergui Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum Proc. Natl. Acad. Sci. U. S. A. 101 2004 2191 2196
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 2191-2196
    • Chergui, K.1
  • 5
    • 0036386814 scopus 로고    scopus 로고
    • Glutamate-mediated striatal dysregulation and the pathogenesis of motor response complications in Parkinson's disease
    • J.D. Oh, and T.N. Chase Glutamate-mediated striatal dysregulation and the pathogenesis of motor response complications in Parkinson's disease Amino Acids 23 2002 133 139
    • (2002) Amino Acids , vol.23 , pp. 133-139
    • Oh, J.D.1    Chase, T.N.2
  • 6
    • 0344823864 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease
    • P.D. Smith Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease Proc. Natl. Acad. Sci. U. S. A. 100 2003 13650 13655
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 13650-13655
    • Smith, P.D.1
  • 7
    • 0842324788 scopus 로고    scopus 로고
    • Recycling the cell cycle: Cyclins revisited
    • A.W. Murray Recycling the cell cycle: cyclins revisited Cell 116 2004 221 234
    • (2004) Cell , vol.116 , pp. 221-234
    • Murray, A.W.1
  • 8
    • 0036897835 scopus 로고    scopus 로고
    • A revised picture of the E2F transcriptional network and RB function
    • O. Stevaux, and N.J. Dyson A revised picture of the E2F transcriptional network and RB function Curr. Opin. Cell Biol. 14 2002 684 691
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 684-691
    • Stevaux, O.1    Dyson, N.J.2
  • 9
    • 0642286495 scopus 로고    scopus 로고
    • Cyclin B1 and CDK1: Nuclear localization and upstream regulators
    • L.A. Porter, and D.J. Donoghue Cyclin B1 and CDK1: nuclear localization and upstream regulators Prog. Cell Cycle Res. 5 2003 335 347
    • (2003) Prog. Cell Cycle Res. , vol.5 , pp. 335-347
    • Porter, L.A.1    Donoghue, D.J.2
  • 10
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • C.J. Sherr, and J.M. Roberts CDK inhibitors: positive and negative regulators of G1-phase progression Genes Dev. 13 1999 1501 1512
    • (1999) Genes Dev. , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 11
    • 0038052805 scopus 로고    scopus 로고
    • The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer
    • K. Vermeulen The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer Cell Prolif. 36 2003 131 149
    • (2003) Cell Prolif. , vol.36 , pp. 131-149
    • Vermeulen, K.1
  • 12
    • 0035058466 scopus 로고    scopus 로고
    • Activation of cell-cycle-associated proteins in neuronal death: A mandatory or dispensable path?
    • A. Copani Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path? Trends Neurosci. 24 2001 25 31
    • (2001) Trends Neurosci. , vol.24 , pp. 25-31
    • Copani, A.1
  • 13
    • 0032547801 scopus 로고    scopus 로고
    • Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents
    • D.S. Park Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents J. Cell Biol. 143 1998 457 467
    • (1998) J. Cell Biol. , vol.143 , pp. 457-467
    • Park, D.S.1
  • 14
    • 0033516567 scopus 로고    scopus 로고
    • Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death
    • A. Giovanni Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death J. Biol. Chem. 274 1999 19011 19016
    • (1999) J. Biol. Chem. , vol.274 , pp. 19011-19016
    • Giovanni, A.1
  • 15
    • 0035879076 scopus 로고    scopus 로고
    • Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death
    • J. Katchanov Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death J. Neurosci. 21 2001 5045 5053
    • (2001) J. Neurosci. , vol.21 , pp. 5045-5053
    • Katchanov, J.1
  • 16
    • 0030694346 scopus 로고    scopus 로고
    • Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons
    • D.S. Park Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons J. Neurosci. 17 1997 8975 8983
    • (1997) J. Neurosci. , vol.17 , pp. 8975-8983
    • Park, D.S.1
  • 17
    • 0034192510 scopus 로고    scopus 로고
    • Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage
    • D.S. Park Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage J. Neurosci. 20 2000 3104 3114
    • (2000) J. Neurosci. , vol.20 , pp. 3104-3114
    • Park, D.S.1
  • 18
    • 0034697299 scopus 로고    scopus 로고
    • E2F1 mediates death of β-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3
    • A. Giovanni E2F1 mediates death of β-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3 J. Biol. Chem. 275 2000 11553 11560
    • (2000) J. Biol. Chem. , vol.275 , pp. 11553-11560
    • Giovanni, A.1
  • 19
    • 0034682777 scopus 로고    scopus 로고
    • Induction and modulation of cerebellar granule neuron death by E2F-1
    • M.J. O'Hare Induction and modulation of cerebellar granule neuron death by E2F-1 J. Biol. Chem. 275 2000 25358 25364
    • (2000) J. Biol. Chem. , vol.275 , pp. 25358-25364
    • O'Hare, M.J.1
  • 20
    • 0032787503 scopus 로고    scopus 로고
    • Mitotic signaling by β-amyloid causes neuronal death
    • A. Copani Mitotic signaling by β-amyloid causes neuronal death FASEB J. 13 1999 2225 2234
    • (1999) FASEB J. , vol.13 , pp. 2225-2234
    • Copani, A.1
  • 21
    • 0037442820 scopus 로고    scopus 로고
    • Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition
    • H.J. Rideout Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition J. Neurosci. 23 2003 1237 1245
    • (2003) J. Neurosci. , vol.23 , pp. 1237-1245
    • Rideout, H.J.1
  • 22
    • 0036282745 scopus 로고    scopus 로고
    • Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery
    • Y. Konishi Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery Mol. Cell 9 2002 1005 1016
    • (2002) Mol. Cell , vol.9 , pp. 1005-1016
    • Konishi, Y.1
  • 23
    • 0026492630 scopus 로고
    • Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice
    • R.M. Feddersen Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice Neuron 9 1992 955 966
    • (1992) Neuron , vol.9 , pp. 955-966
    • Feddersen, R.M.1
  • 24
    • 0029018228 scopus 로고
    • In vivo viability of postmitotic Purkinje neurons requires pRb family member function
    • R.M. Feddersen In vivo viability of postmitotic Purkinje neurons requires pRb family member function Mol. Cell. Neurosci. 6 1995 153 167
    • (1995) Mol. Cell. Neurosci. , vol.6 , pp. 153-167
    • Feddersen, R.M.1
  • 25
    • 0033539696 scopus 로고    scopus 로고
    • Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases
    • F. Zindy Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases Proc. Natl. Acad. Sci. U. S. A. 96 1999 13462 13467
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 13462-13467
    • Zindy, F.1
  • 26
    • 0034730122 scopus 로고    scopus 로고
    • Cyclin-dependent kinases as a therapeutic target for stroke
    • H. Osuga Cyclin-dependent kinases as a therapeutic target for stroke Proc. Natl. Acad. Sci. U. S. A. 97 2000 10254 10259
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 10254-10259
    • Osuga, H.1
  • 27
    • 0037444453 scopus 로고    scopus 로고
    • Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1
    • M.D. Nguyen Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1 J. Neurosci. 23 2003 2131 2140
    • (2003) J. Neurosci. , vol.23 , pp. 2131-2140
    • Nguyen, M.D.1
  • 28
    • 0032522911 scopus 로고    scopus 로고
    • Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
    • J. Busser Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain J. Neurosci. 18 1998 2801 2807
    • (1998) J. Neurosci. , vol.18 , pp. 2801-2807
    • Busser, J.1
  • 29
    • 0033635551 scopus 로고    scopus 로고
    • Mitotic activation: A convergent mechanism for a cohort of neurodegenerative diseases
    • J.W. Husseman Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases Neurobiol. Aging 21 2000 815 828
    • (2000) Neurobiol. Aging , vol.21 , pp. 815-828
    • Husseman, J.W.1
  • 30
    • 0036884184 scopus 로고    scopus 로고
    • Erratic expression of DNA polymerases by β-amyloid causes neuronal death
    • A. Copani Erratic expression of DNA polymerases by β-amyloid causes neuronal death FASEB J. 16 2002 2006 2008
    • (2002) FASEB J. , vol.16 , pp. 2006-2008
    • Copani, A.1
  • 31
    • 0033637884 scopus 로고    scopus 로고
    • β-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons
    • Q. Wu β-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons Neurobiol. Aging 21 2000 797 806
    • (2000) Neurobiol. Aging , vol.21 , pp. 797-806
    • Wu, Q.1
  • 32
    • 0035871660 scopus 로고    scopus 로고
    • DNA replication precedes neuronal cell death in Alzheimer's disease
    • Y. Yang DNA replication precedes neuronal cell death in Alzheimer's disease J. Neurosci. 21 2001 2661 2668
    • (2001) J. Neurosci. , vol.21 , pp. 2661-2668
    • Yang, Y.1
  • 33
    • 0037422010 scopus 로고    scopus 로고
    • Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
    • J.F. Staropoli Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity Neuron 37 2003 735 749
    • (2003) Neuron , vol.37 , pp. 735-749
    • Staropoli, J.F.1
  • 34
    • 0037229278 scopus 로고    scopus 로고
    • Expression patterns of retinoblastoma protein in Parkinson disease
    • K.L. Jordan-Sciutto Expression patterns of retinoblastoma protein in Parkinson disease J. Neuropathol. Exp. Neurol. 62 2003 68 74
    • (2003) J. Neuropathol. Exp. Neurol. , vol.62 , pp. 68-74
    • Jordan-Sciutto, K.L.1
  • 35
    • 0029768093 scopus 로고    scopus 로고
    • Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death
    • T. Ohshima Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death Proc. Natl. Acad. Sci. U. S. A. 93 1996 11173 11178
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 11173-11178
    • Ohshima, T.1
  • 36
    • 0035966018 scopus 로고    scopus 로고
    • Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology
    • T. Rashid Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology J. Biol. Chem. 276 2001 49043 49052
    • (2001) J. Biol. Chem. , vol.276 , pp. 49043-49052
    • Rashid, T.1
  • 37
    • 0031018336 scopus 로고    scopus 로고
    • Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality
    • T. Chae Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality Neuron 18 1997 29 42
    • (1997) Neuron , vol.18 , pp. 29-42
    • Chae, T.1
  • 38
    • 0034611632 scopus 로고    scopus 로고
    • Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase
    • Y.T. Kwon Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase Curr. Biol. 10 2000 363 372
    • (2000) Curr. Biol. , vol.10 , pp. 363-372
    • Kwon, Y.T.1
  • 40
    • 0034079916 scopus 로고    scopus 로고
    • nck5a interaction with synaptic proteins in bovine brain
    • nck5a interaction with synaptic proteins in bovine brain J. Cell. Biochem. 78 2000 151 159
    • (2000) J. Cell. Biochem. , vol.78 , pp. 151-159
    • Rosales, J.L.1
  • 41
    • 0033540078 scopus 로고    scopus 로고
    • Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
    • J.A. Bibb Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons Nature 402 1999 669 671
    • (1999) Nature , vol.402 , pp. 669-671
    • Bibb, J.A.1
  • 42
    • 0027978170 scopus 로고
    • P35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
    • L.H. Tsai p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 Nature 371 1994 419 423
    • (1994) Nature , vol.371 , pp. 419-423
    • Tsai, L.H.1
  • 43
    • 0028858467 scopus 로고
    • An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator
    • D. Tang An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator J. Biol. Chem. 270 1995 26897 26903
    • (1995) J. Biol. Chem. , vol.270 , pp. 26897-26903
    • Tang, D.1
  • 44
    • 0033710860 scopus 로고    scopus 로고
    • Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth
    • L.R. Zukerberg Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth Neuron 26 2000 633 646
    • (2000) Neuron , vol.26 , pp. 633-646
    • Zukerberg, L.R.1
  • 45
    • 0242353366 scopus 로고    scopus 로고
    • Cdk7 functions as a cdk5 activating kinase in brain
    • J. Rosales Cdk7 functions as a cdk5 activating kinase in brain Cell. Physiol. Biochem. 13 2003 285 296
    • (2003) Cell. Physiol. Biochem. , vol.13 , pp. 285-296
    • Rosales, J.1
  • 46
    • 0034786018 scopus 로고    scopus 로고
    • nck5a complex
    • nck5a complex Mol. Cell 8 2001 657 669
    • (2001) Mol. Cell , vol.8 , pp. 657-669
    • Tarricone, C.1
  • 47
    • 0033540060 scopus 로고    scopus 로고
    • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    • G.N. Patrick Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Nature 402 1999 615 622
    • (1999) Nature , vol.402 , pp. 615-622
    • Patrick, G.N.1
  • 48
    • 0034682414 scopus 로고    scopus 로고
    • Neurotoxicity induces cleavage of p35 to p25 by calpain
    • M.S. Lee Neurotoxicity induces cleavage of p35 to p25 by calpain Nature 405 2000 360 364
    • (2000) Nature , vol.405 , pp. 360-364
    • Lee, M.S.1
  • 49
    • 0032859938 scopus 로고    scopus 로고
    • Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death
    • A. Alvarez Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death FEBS Lett. 459 1999 421 426
    • (1999) FEBS Lett. , vol.459 , pp. 421-426
    • Alvarez, A.1
  • 50
    • 0037431130 scopus 로고    scopus 로고
    • Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis
    • X. Gong Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis Neuron 38 2003 33 46
    • (2003) Neuron , vol.38 , pp. 33-46
    • Gong, X.1
  • 51
    • 17744368458 scopus 로고    scopus 로고
    • Deregulation of Cdk5 in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions
    • M.D. Nguyen Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions Neuron 30 2001 135 147
    • (2001) Neuron , vol.30 , pp. 135-147
    • Nguyen, M.D.1
  • 52
    • 0036703779 scopus 로고    scopus 로고
    • Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model
    • B. Bu Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model J. Neurosci. 22 2002 6515 6525
    • (2002) J. Neurosci. , vol.22 , pp. 6515-6525
    • Bu, B.1
  • 53
    • 0036259186 scopus 로고    scopus 로고
    • Controversies over p25 in Alzheimer's disease
    • K.C. Nguyen Controversies over p25 in Alzheimer's disease J. Alzheimers Dis. 4 2002 123 126
    • (2002) J. Alzheimers Dis. , vol.4 , pp. 123-126
    • Nguyen, K.C.1
  • 54
    • 0345405447 scopus 로고    scopus 로고
    • Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
    • J.C. Cruz Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles Neuron 40 2003 471 483
    • (2003) Neuron , vol.40 , pp. 471-483
    • Cruz, J.C.1
  • 55
    • 0141542665 scopus 로고    scopus 로고
    • Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors
    • J. Wang Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors Nat. Neurosci. 6 2003 1039 1047
    • (2003) Nat. Neurosci. , vol.6 , pp. 1039-1047
    • Wang, J.1
  • 56
    • 0036312755 scopus 로고    scopus 로고
    • Cdk5 phosphorylates p53 and regulates its activity
    • J. Zhang Cdk5 phosphorylates p53 and regulates its activity J. Neurochem. 81 2002 307 313
    • (2002) J. Neurochem. , vol.81 , pp. 307-313
    • Zhang, J.1
  • 57
    • 0030249597 scopus 로고    scopus 로고
    • Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity
    • P.A. Trimmer Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity Neurodegeneration 5 1996 233 239
    • (1996) Neurodegeneration , vol.5 , pp. 233-239
    • Trimmer, P.A.1
  • 58
    • 0036469286 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3
    • B.S. Li Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3 EMBO J. 21 2002 324 333
    • (2002) EMBO J. , vol.21 , pp. 324-333
    • Li, B.S.1
  • 59
    • 0028828550 scopus 로고
    • Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5
    • J.P. Brion, and A.M. Couck Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5 Am. J. Pathol. 147 1995 1465 1476
    • (1995) Am. J. Pathol. , vol.147 , pp. 1465-1476
    • Brion, J.P.1    Couck, A.M.2
  • 60
    • 0030749732 scopus 로고    scopus 로고
    • nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease
    • nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease Acta Neuropathol. (Berl.) 94 1997 153 157
    • (1997) Acta Neuropathol. (Berl.) , vol.94 , pp. 153-157
    • Nakamura, S.1
  • 61
    • 0031564837 scopus 로고    scopus 로고
    • Increased expression of cyclin-dependent kinase 5 in induced apoptotic neuron death in rat substantia nigra
    • C. Henchcliffe, and R.E. Burke Increased expression of cyclin-dependent kinase 5 in induced apoptotic neuron death in rat substantia nigra Neurosci. Lett. 230 1997 41 44
    • (1997) Neurosci. Lett. , vol.230 , pp. 41-44
    • Henchcliffe, C.1    Burke, R.E.2
  • 62
    • 0034972511 scopus 로고    scopus 로고
    • Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo
    • M. Neystat Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo J. Neurochem. 77 2001 1611 1625
    • (2001) J. Neurochem. , vol.77 , pp. 1611-1625
    • Neystat, M.1
  • 63
    • 0037224933 scopus 로고    scopus 로고
    • Ectopic expression of cell cycle markers in models of induced programmed cell death in dopamine neurons of the rat substantia nigra pars compacta
    • B.F. El-Khodor Ectopic expression of cell cycle markers in models of induced programmed cell death in dopamine neurons of the rat substantia nigra pars compacta Exp. Neurol. 179 2003 17 27
    • (2003) Exp. Neurol. , vol.179 , pp. 17-27
    • El-Khodor, B.F.1
  • 64
    • 0031031008 scopus 로고    scopus 로고
    • GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine
    • J.L. Tseng GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine J. Neurosci. 17 1997 325 333
    • (1997) J. Neurosci. , vol.17 , pp. 325-333
    • Tseng, J.L.1
  • 65
    • 0037147762 scopus 로고    scopus 로고
    • Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: Feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease
    • T.J. Collier Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease J. Comp. Neurol. 442 2002 320 330
    • (2002) J. Comp. Neurol. , vol.442 , pp. 320-330
    • Collier, T.J.1
  • 66
    • 0035818540 scopus 로고    scopus 로고
    • C-Jun mediates axotomy-induced dopamine neuron death in vivo
    • S.J. Crocker c-Jun mediates axotomy-induced dopamine neuron death in vivo Proc. Natl. Acad. Sci. U. S. A. 98 2001 13385 13390
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 13385-13390
    • Crocker, S.J.1
  • 67
    • 0038380524 scopus 로고    scopus 로고
    • Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease
    • S.J. Crocker Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease J. Neurosci. 23 2003 4081 4091
    • (2003) J. Neurosci. , vol.23 , pp. 4081-4091
    • Crocker, S.J.1
  • 68
    • 0031054972 scopus 로고    scopus 로고
    • Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein
    • K.Y. Lee Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein J. Biol. Chem. 272 1997 5622 5626
    • (1997) J. Biol. Chem. , vol.272 , pp. 5622-5626
    • Lee, K.Y.1
  • 69
    • 0030957684 scopus 로고    scopus 로고
    • A novel cdc2-related protein kinase expressed in the nervous system
    • M.A. Lazzaro A novel cdc2-related protein kinase expressed in the nervous system J. Neurochem. 69 1997 348 364
    • (1997) J. Neurochem. , vol.69 , pp. 348-364
    • Lazzaro, M.A.1
  • 70
    • 0028924026 scopus 로고
    • PITSLRE protein kinase activity is associated with apoptosis
    • J.M. Lahti PITSLRE protein kinase activity is associated with apoptosis Mol. Cell. Biol. 15 1995 1 11
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1-11
    • Lahti, J.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.