MSFTZ, a flavanone derivative, induces human hepatoma cell apoptosis via a reactive oxygen species- and caspase-dependent mitochondrial pathway

Journal of Pharmacology and Experimental Therapeutics

Volumn 325, Issue 3, 2008, Pages 758-765

  Ying, Meidan ^a   Tu, Chongxing ^a   Ying, Huazhou ^b   Hu, Yongzhou ^b   He, Qiaojun ^a   Yang, Bo ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CHLORO 4 METHYLSULFONYLPHENYL) 4' CHLORO 3ALPHA,4 DIETHOXYFLAVANE[4,3 D] D1,9B 1,2,3 THIADIAZOLINE; ACETYLCYSTEINE; CASPASE; CASPASE 3; CASPASE 9; FLAVONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STRESS; TUMOR VOLUME; TUMOR XENOGRAFT;

ACETYLCYSTEINE; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BENZOPYRANS; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; FLAVANONES; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM TRANSPLANTATION; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; THIADIAZOLES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 44249113075     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.135657     Document Type: Article

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