Sapphyrins induce apoptosis in hematopoietic tumor-derived cell lines and show in vivo antitumor activity

Molecular Cancer Therapeutics

Volumn 4, Issue 6, 2005, Pages 968-976

  Naumovski, Louie ^a   Ramos, Jason ^a   Sirisawad, Mint ^a   Chen, Jun ^a   Thiemann, Patti ^a   Lecane, Philip ^a   Magda, Darren ^a   Wang, Zhong ^a   Cortez, Cecilia ^a   Boswell, Garry ^a   Cho, Dong Gyu ^b   Sessler, Jonathan ^b   Miller, Richard ^a  

^a PHARMACYCLICS INC   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CYTOCHROME C; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE P38; PCI 2000; PCI 2010; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PORPHYRIN; PROTEIN BCL 2; SAPPHYRIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HEMATOPOIETIC CELL; IN VIVO STUDY; LEUKEMIA; LYMPHOMA; MITOCHONDRION; MOUSE; MYELOMA; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT;

ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CYTOCHROMES C; CYTOPLASM; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA; LYMPHOMA; MICE; MICE, NUDE; MITOCHONDRIA; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PORPHYRINS; PROTO-ONCOGENE PROTEINS C-BCL-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 21344450769     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-04-0339     Document Type: Article

References (22)

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