RAP250 is a coactivator in the transforming growth factor β signaling pathway that interacts with Smad2 and Smad3

Journal of Biological Chemistry

Volumn 283, Issue 14, 2008, Pages 8995-9001

  Antonson, Per ^a   Jakobsson, Tomas ^a   Almlöf, Tova ^a   Guldevall, Karolin ^a   Steffensen, Knut R ^a   Gustafsson, Jan Åke ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; BIOCHEMISTRY; CELL CULTURE; FLOW INTERACTIONS; GROWTH (MATERIALS); PEPTIDES; PROTEINS; SIGNALING; TRANSCRIPTION; TRANSCRIPTION FACTORS;

BIOLOGICAL PROCESSES; BRIDGING MECHANISMS; CDNA LIBRARIES; DO-MAINS; HYBRID SYSTEMS; INTRACELLULAR MEDIATORS; LIVER X RECEPTORS; MECHANISM OF ACTIONS; MOUSE EMBRYONIC FIBROBLASTS; NOVEL PROTEINS; NUCLEAR RECEPTORS; SIGNALING PATHWAYS; SYNERGISTIC EFFECTS; TARGET GENES; TRANSFORMING GROWTH FACTORS; WILD TYPES;

PIGMENTS;

ABC TRANSPORTER G1; LIVER X RECEPTOR; RAP250 PROTEIN; REGULATOR PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCG1 PROTEIN, HUMAN; ABCG1 PROTEIN, MOUSE; CELL RECEPTOR; COMPLEMENTARY DNA; DNA BINDING PROTEIN; LIPOPROTEIN; NCOA6 PROTEIN, HUMAN; NCOA6 PROTEIN, MOUSE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERINE PROTEINASE INHIBITOR; SERPINE1 PROTEIN, HUMAN; SERPINE2 PROTEIN, MOUSE; SIGNAL PEPTIDE; SMAD2 PROTEIN, HUMAN; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN, HUMAN; SMAD3 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE EXPRESSION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; CELL STRAIN U937; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; EMBRYO (ANATOMY); GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; TWO HYBRID SYSTEM;

AMINO ACID MOTIFS; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; FIBROBLASTS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPROTEINS; MICE; MICE, KNOCKOUT; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SERPINS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TWO-HYBRID SYSTEM TECHNIQUES; U937 CELLS;

EID: 44049101411     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707203200     Document Type: Article

References (44)

1. Lonard, D. M., and O'Malley, B. W. (2006) Cell 125, 411-414
2. Roberts, C. W., and Orkin, S. H. (2004) Nat. Rev. Cancer 4, 133-142
3. Hermanson, O., Glass, C. K., and Rosenfeld, M. G. (2002) Trends Endocrinol. Metab. 13, 55-60
4. Malik, S., and Roeder, R. G. (2005) Trends Biochem. Sci. 30, 256-263
5. Savkur, R. S., and Burris, T. P. (2004) J. Pept. Res. 63, 207-212
6. Puigserver, P., and Spiegelman, B. M. (2003) Endocr. Rev. 24, 78-90
7. Ito, M., and Roeder, R. G. (2001) Trends Endocrinol. Metab. 12, 127-134
8. Mahajan, M. A., and Samuels, H. H. (2005) Endocr. Rev. 26, 583-597
9. Caira, F., Antonson, P., Pelto-Huikko, M., Treuter, E., and Gustafsson, J.-Å. (2000) J. Biol. Chem. 275, 5308-5317
10. Lee, S. K., Jung, S. Y., Kim, Y. S., Na, S. Y., Lee, Y. C., and Lee, J. W. (2001) Mol. Endocrinol. 15, 241-254
11. Ko, L., Cardona, G. R., and Chin, W. W. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6212-6217
12. Mahajan, M. A., and Samuels, H. H. (2000) Mol. Cell. Biol. 20, 5048-5063
13. Zhu, Y., Qi, C., Cao, W. Q., Yeldandi, A. V., Rao, M. S., and Reddy, J. K. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 10380-10385
14. Ju, B. G., Lunyak, V. V., Perissi, V., Garcia-Bassets, I., Rose, D. W., Glass, C. K., and Rosenfeld, M. G. (2006) Science 312, 1798-1802
15. Kuang, S. Q., Liao, L., Zhang, H., Pereira, F. A., Yuan, Y., DeMayo, F. J., Ko, L., and Xu, J. (2002) J. Biol. Chem. 277, 45356-45360
16. Antonson, P., Schuster, G. U., Wang, L., Rozell, B., Holter, E., Flodby, P., Treuter, E., Holmgren, L., and Gustafsson, J.-Å. (2003) Mol. Cell. Biol. 23, 1260-1268
17. Zhu, Y. J., Crawford, S. E., Stellmach, V., Dwivedi, R. S., Rao, M. S., Gonzalez, F. J., Qi, C., and Reddy, J. K. (2003) J. Biol. Chem. 278, 1986-1990
18. Mahajan, M. A., Das, S., Zhu, H., Tomic-Canic, M., and Samuels, H. H. (2004) Mol. Cell. Biol. 24, 4994-5004
19. Kim, S. W., Park, K., Kwak, E., Choi, E., Lee, S., Ham, J., Kang, H., Kim, J. M., Hwang, S. Y., Kong, Y. Y., Lee, K., and Lee, J. W. (2003) Mol. Cell. Biol. 23, 3583-3592
20. Steffensen, K. R., and Gustafsson, J.-Å. (2006) Future Lipidol. 1, 181-189
21. Argmann, C. A., Van Den Diepstraten, C. H., Sawyez, C. G., Edwards, J. Y., Hegele, R. A., Wolfe, B. M., and Huff, M. W. (2001) Arterioscler. Thromb. Vasc. Biol. 21, 2011-2018
22. Panousis, C. G., Evans, G., and Zuckerman, S. H. (2001) J. Lipid Res. 42, 856-863
23. Singh, N. N., and Ramji, D. P. (2006) Arterioscler. Thromb. Vasc. Biol. 26, 1323-1329
24. Nakao, A., Imamura, T., Souchelnytskyi, S., Kawabata, M., Ishisaki, A., Oeda, E., Tamaki, K., Hanai, J., Heldin, C. H., Miyazono, K., and ten Dijke, P. (1997) EMBO J. 16, 5353-5362
25. Alberti, S., Schuster, G., Parini, P., Feltkamp, D., Diczfalusy, U., Rudling, M., Angelin, B., Björkhem, I., Pettersson, S., and Gustafsson, J.-Å. (2001) J. Clin. Investig. 107, 565-573
26. Collins, J. L., Fivush, A. M., Watson, M. A., Galardi, C. M., Lewis, M. C., Moore, L. B., Parks, D. J., Wilson, J. G., Tippin, T. K., Binz, J. G., Plunket, K. D., Morgan, D. G., Beaudet, E. J., Whitney, K. D., Kliewer, S. A., and Willson, T. M. (2002) J. Med. Chem. 45, 1963-1966
27. Schultz, J. R., Tu, H., Luk, A., Repa, J. J., Medina, J. C., Li, L., Schwendner, S., Wang, S., Thoolen, M., Mangelsdorf, D. J., Lustig, K. D., and Shan, B. (2000) Genes Dev. 14, 2831-2838
28. Moustakas, A., Souchelnytskyi, S., and Heldin, C.-H. (2001) J. Cell Sci. 114, 4359-4369
29. Shi, Y., and Massague, J. (2003) Cell 113, 685-700
30. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J. M. (1998) EMBO J. 17, 3091-3100
31. Hua, X., Liu, X., Ansari, D. O., and Lodish, H. F. (1998) Genes Dev. 12, 3084-3095
32. Janknecht, R., Wells, N. J., and Hunter, T. (1998) Genes Dev. 12, 2114-2119
33. Feng, X. H., Zhang, Y., Wu, R. Y., and Derynck, R. (1998) Genes Dev. 12, 2153-2163
34. Kato, Y., Habas, R., Katsuyama, Y., Näär, A. M., and He, X. (2002) Nature 418, 641-646
35. Heery, D. M., Kalkhoven, E., Hoare, S., and Parker, M. G. (1997) Nature 387, 733-736
36. Torchia, J., Rose, D. W., Inostroza, J., Kamei, Y., Westin, S., Glass, C. K., and Rosenfeld, M. G. (1997) Nature 387, 677-684
37. Plevin, M. J., Mills, M. M., and Ikura, M. (2005) Trends Biochem. Sci. 30, 66-69
38. McInerney, E. M., Rose, D. W., Flynn, S. E., Westin, S., Mullen, T. M., Krones, A., Inostroza, J., Torchia, J., Nolte, R. T., Assa-Munt, N., Milburn, M. V., Glass, C. K., and Rosenfeld, M. G. (1998) Genes Dev. 12, 3357-3368
39. Wu, G., Chen, Y. G., Ozdamar, B., Gyuricza, C. A., Chong, P. A., Wrana, J. L., Massague, J., and Shi, Y. (2000) Science 287, 92-97
40. Randall, R. A., Germain, S., Inman, G. J., Bates, P. A., and Hill, C. S. (2002) EMBO J. 21, 145-156
41. Derynck, R., Zhang, Y., and Feng, X. H. (1998) Cell 95, 737-740
42. Matsuda, T., Yamamoto, T., Muraguchi, A., and Saatcioglu, F. (2001) J. Biol. Chem. 276, 42908-42914
43. Yanagisawa, J., Yanagi, Y., Masuhiro, Y., Suzawa, M., Watanabe, M., Kashiwagi, K., Toriyabe, T., Kawabata, M., Miyazono, K., and Kato, S. (1999) Science 283, 1317-1321
44. Li, Q., Chu, M. J., and Xu, J. (2007) Mol. Cell. Biol. 27, 8073-8086