메뉴 건너뛰기




Volumn 13, Issue 6, 2008, Pages 606-613

Anxiety is associated with reduced central serotonin transporter availability in unmedicated patients with unipolar major depression: A [ 11C]DASB PET study

Author keywords

BDI; Negative mood states; PET; Serotonin transporter; STAI; Thalamus

Indexed keywords

AMINO 4 (2 DIMETHYLAMINOMETHYLPHENYLSULFANYL) BENZONITRILE C 11; RADIOLIGAND; SEROTONIN TRANSPORTER;

EID: 43949111033     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4002149     Document Type: Article
Times cited : (112)

References (51)
  • 1
    • 0031010706 scopus 로고    scopus 로고
    • Fluoxetine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with major depression or with obsessive compulsive disorder
    • Meltzer H, Bastani B, Jayathilake K, Maes M. Fluoxetine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with major depression or with obsessive compulsive disorder. Neuropsychopharmacology 1997; 17: 1-11.
    • (1997) Neuropsychopharmacology , vol.17 , pp. 1-11
    • Meltzer, H.1    Bastani, B.2    Jayathilake, K.3    Maes, M.4
  • 3
    • 0028980784 scopus 로고
    • Beta-CIT SPECT demonstrates blockade of 5HT-uptake sites by citalopram in the human brain in vivo
    • Pirker W, Asenbaum S, Kasper S, Walter H, Angelberger P, Koch G et al. Beta-CIT SPECT demonstrates blockade of 5HT-uptake sites by citalopram in the human brain in vivo. J Neural Transm Gen Sect 1995; 100: 247-256.
    • (1995) J Neural Transm Gen Sect , vol.100 , pp. 247-256
    • Pirker, W.1    Asenbaum, S.2    Kasper, S.3    Walter, H.4    Angelberger, P.5    Koch, G.6
  • 4
    • 0017296144 scopus 로고
    • Serotonin depression' - a biochemical subgroup within the affective disorders?
    • Asberg M, Thoren P, Traskman L, Bertilsson L, Ringberger V. 'Serotonin depression' - a biochemical subgroup within the affective disorders? Science 1976; 191: 478-480.
    • (1976) Science , vol.191 , pp. 478-480
    • Asberg, M.1    Thoren, P.2    Traskman, L.3    Bertilsson, L.4    Ringberger, V.5
  • 8
    • 0034652809 scopus 로고    scopus 로고
    • 123I]-beta-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder
    • 123I]-beta-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder. Biol Psychiatry 2000; 47: 482-489.
    • (2000) Biol Psychiatry , vol.47 , pp. 482-489
    • Willeit, M.1    Praschak-Rieder, N.2    Neumeister, A.3    Pirker, W.4    Asenbaum, S.5    Vitouch, O.6
  • 10
    • 4544334735 scopus 로고    scopus 로고
    • Depletion and restoration of endogenous monoamines affects β-CIT binding to serotonin but not dopamine transporters in non-human primates
    • Heinz A, Jones DW, Zajicek K, Gorey JG, Juckel G, Higley JD et al. Depletion and restoration of endogenous monoamines affects β-CIT binding to serotonin but not dopamine transporters in non-human primates. J Neural Transm 2004; 68(Suppl): 29-38.
    • (2004) J Neural Transm , vol.68 , Issue.SUPPL. , pp. 29-38
    • Heinz, A.1    Jones, D.W.2    Zajicek, K.3    Gorey, J.G.4    Juckel, G.5    Higley, J.D.6
  • 11
    • 0031848037 scopus 로고    scopus 로고
    • In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates
    • Heinz A, Higley JD, Gorey JG, Saunders RC, Jones DW, Hommer D et al. In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates. Am J Psychiatry 1998; 155: 1023-1028.
    • (1998) Am J Psychiatry , vol.155 , pp. 1023-1028
    • Heinz, A.1    Higley, J.D.2    Gorey, J.G.3    Saunders, R.C.4    Jones, D.W.5    Hommer, D.6
  • 13
    • 0028285393 scopus 로고
    • Whole-body biodistribution, radiation absorbed dose and brain SPECT imaging with iodine-123-beta-CIT in healthy human subjects
    • Seibyl JP, Wallace E, Smith EO, Stabin M, Baldwin RM, Zoghbi S et al. Whole-body biodistribution, radiation absorbed dose and brain SPECT imaging with iodine-123-beta-CIT in healthy human subjects. J Nucl Med 1994; 35: 764-770.
    • (1994) J Nucl Med , vol.35 , pp. 764-770
    • Seibyl, J.P.1    Wallace, E.2    Smith, E.O.3    Stabin, M.4    Baldwin, R.M.5    Zoghbi, S.6
  • 15
    • 0033972410 scopus 로고    scopus 로고
    • Imaging serotonin and dopamine transporters with 123I-beta-CIT SPECT: Binding kinetics and effects of normal aging
    • Pirker W, Asenbaum S, Hauk M, Kandlhofer S, Tauscher J, Willeit M et al. Imaging serotonin and dopamine transporters with 123I-beta-CIT SPECT: binding kinetics and effects of normal aging. J Nucl Med 2000; 41: 36-44.
    • (2000) J Nucl Med , vol.41 , pp. 36-44
    • Pirker, W.1    Asenbaum, S.2    Hauk, M.3    Kandlhofer, S.4    Tauscher, J.5    Willeit, M.6
  • 17
    • 30044435499 scopus 로고    scopus 로고
    • Lower serotonin transporter binding potential in the human brain during major depressive episodes
    • Parsey RV, Hastings RS, Oquendo MA, Huang YY, Simpson N, Arcement J et al. Lower serotonin transporter binding potential in the human brain during major depressive episodes. Am J Psychiatry 2006; 163: 52-58.
    • (2006) Am J Psychiatry , vol.163 , pp. 52-58
    • Parsey, R.V.1    Hastings, R.S.2    Oquendo, M.A.3    Huang, Y.Y.4    Simpson, N.5    Arcement, J.6
  • 21
    • 4444332553 scopus 로고    scopus 로고
    • Hummerich R, Reischl G, Ehrlichmann W, Machulla HJ, Heinz A, Schloss P. DASB - in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as a PET tracer. J Neurochem 2004; 90: 1218-1226.
    • Hummerich R, Reischl G, Ehrlichmann W, Machulla HJ, Heinz A, Schloss P. DASB - in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as a PET tracer. J Neurochem 2004; 90: 1218-1226.
  • 22
    • 10044278067 scopus 로고    scopus 로고
    • Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: Effects of major depressive episodes and severity of dysfunctional attitudes
    • Meyer JH, Houle S, Sagrati S, Carella A, Hussey DF, Ginovart N et al. Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes. Arch Gen Psychiatry 2004; 61: 1271-1279.
    • (2004) Arch Gen Psychiatry , vol.61 , pp. 1271-1279
    • Meyer, J.H.1    Houle, S.2    Sagrati, S.3    Carella, A.4    Hussey, D.F.5    Ginovart, N.6
  • 23
    • 34247137134 scopus 로고    scopus 로고
    • Imaging the serotonin transporter during major depressive disorder and antidepressant treatment
    • Meyer JH. Imaging the serotonin transporter during major depressive disorder and antidepressant treatment. J Psychiatry Neurosci 2007; 32: 86-102.
    • (2007) J Psychiatry Neurosci , vol.32 , pp. 86-102
    • Meyer, J.H.1
  • 25
    • 0006463359 scopus 로고    scopus 로고
    • Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
    • Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
    • (1996) Science , vol.274 , pp. 1527-1531
    • Lesch, K.P.1    Bengel, D.2    Heils, A.3    Sabol, S.Z.4    Greenberg, B.D.5    Petri, S.6
  • 26
    • 0034176712 scopus 로고    scopus 로고
    • Serotonin transporter genotype interacts with in vivo protein expression and chronic alcohol intake
    • Heinz A, Jones DW, Mazzanti C, Goldman D, Ragan P, Hommer D et al. Serotonin transporter genotype interacts with in vivo protein expression and chronic alcohol intake. Biol Psychiatry 2000; 47: 643-649.
    • (2000) Biol Psychiatry , vol.47 , pp. 643-649
    • Heinz, A.1    Jones, D.W.2    Mazzanti, C.3    Goldman, D.4    Ragan, P.5    Hommer, D.6
  • 30
    • 43949138443 scopus 로고    scopus 로고
    • First MB, Spitzer RL, Gibbon M, Williams J. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition With Psychotic Screen. Biometrics Research, New York State Psychiatric Institute: New York, 2001.
    • First MB, Spitzer RL, Gibbon M, Williams J. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition With Psychotic Screen. Biometrics Research, New York State Psychiatric Institute: New York, 2001.
  • 36
    • 3142659486 scopus 로고    scopus 로고
    • 11C]DASB and application in a remote-controlled high yield synthesis
    • 11C]DASB and application in a remote-controlled high yield synthesis. Radiochim Acta 2004; 92: 341-344.
    • (2004) Radiochim Acta , vol.92 , pp. 341-344
    • Solbach, C.1    Reischl, G.2    Machulla, H.-J.3
  • 39
    • 33745684629 scopus 로고    scopus 로고
    • Effect of spatial smoothing on t-maps: Arguments for going back from t-maps to masked contrast images
    • Reimold M, Slifstein M, Heinz A, Müller-Schauenburg W, Bares R. Effect of spatial smoothing on t-maps: arguments for going back from t-maps to masked contrast images. J Cereb Blood Flow Metab 2006; 26: 751-759.
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 751-759
    • Reimold, M.1    Slifstein, M.2    Heinz, A.3    Müller-Schauenburg, W.4    Bares, R.5
  • 40
    • 0026608959 scopus 로고
    • Neurotransmitter actions in the thalamus and cerebral cortex
    • McCormick DA. Neurotransmitter actions in the thalamus and cerebral cortex. J Clin Neurophysiol 1992; 9: 212-223.
    • (1992) J Clin Neurophysiol , vol.9 , pp. 212-223
    • McCormick, D.A.1
  • 43
    • 0036703989 scopus 로고    scopus 로고
    • Serotonin clearance in vivo is altered to a greater extent by antidepressant- induced downregulation of the serotonin transporter than by acute blockade of this transporter
    • Benmansour S, Owens WA, Cecchi M, Morilak DA, Frazer A. Serotonin clearance in vivo is altered to a greater extent by antidepressant- induced downregulation of the serotonin transporter than by acute blockade of this transporter. J Neurosci 2002; 22: 6766-6772.
    • (2002) J Neurosci , vol.22 , pp. 6766-6772
    • Benmansour, S.1    Owens, W.A.2    Cecchi, M.3    Morilak, D.A.4    Frazer, A.5
  • 44
    • 0037135137 scopus 로고    scopus 로고
    • Serotonin transporter genetic variation and the response of the human amygdala
    • Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297: 400-403.
    • (2002) Science , vol.297 , pp. 400-403
    • Hariri, A.R.1    Mattay, V.S.2    Tessitore, A.3    Kolachana, B.4    Fera, F.5    Goldman, D.6
  • 46
    • 16644400562 scopus 로고    scopus 로고
    • Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
    • Heinz A, Braus DF, Smolka MN, Wrase J, Puls I, Hermann D et al. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 2005; 8: 20-21.
    • (2005) Nat Neurosci , vol.8 , pp. 20-21
    • Heinz, A.1    Braus, D.F.2    Smolka, M.N.3    Wrase, J.4    Puls, I.5    Hermann, D.6
  • 47
    • 0031473315 scopus 로고    scopus 로고
    • Neonatal administration of the selective serotonin reuptake inhibitor Lu 10-134-C increases forced swimming-induced immobility in adult rats: A putative animal model of depression?
    • Hansen HH, Sanchez C, Meier E. Neonatal administration of the selective serotonin reuptake inhibitor Lu 10-134-C increases forced swimming-induced immobility in adult rats: a putative animal model of depression? J Pharmacol Exp Ther 1997; 283: 1333-1341.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1333-1341
    • Hansen, H.H.1    Sanchez, C.2    Meier, E.3
  • 48
    • 22844433107 scopus 로고    scopus 로고
    • 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression
    • Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8: 828-834.
    • (2005) Nat Neurosci , vol.8 , pp. 828-834
    • Pezawas, L.1    Meyer-Lindenberg, A.2    Drabant, E.M.3    Verchinski, B.A.4    Munoz, K.E.5    Kolachana, B.S.6
  • 51
    • 0035023028 scopus 로고    scopus 로고
    • Spillmann MK, Van der Does AJ, Rankin MA, Vuolo RD, Alpert JE, Nierenberg AA et al. Tryptophan depletion in SSRI-recovered depressed outpatients. Psychopharmacology 2001; 155: 123-127.
    • Spillmann MK, Van der Does AJ, Rankin MA, Vuolo RD, Alpert JE, Nierenberg AA et al. Tryptophan depletion in SSRI-recovered depressed outpatients. Psychopharmacology 2001; 155: 123-127.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.