Acute Occupancy of Brain Serotonin Transporter by Sertraline as Measured by [11C]DASB and Positron Emission Tomography

Biological Psychiatry

Volumn 59, Issue 9, 2006, Pages 821-828

  Parsey, Ramin V ^a,b   Kent, Justine M ^a,b   Oquendo, Maria A ^a,b   Richards, Misty C ^b   Pratap, Mali ^a,b   Cooper, Thomas B ^b   Arango, Victoria ^a,b   Mann, J John ^a,b  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

cerebellum; PET; reference region; SSRI

Indexed keywords

DRUG METABOLITE; N,N DIMETHYL 2 (2 AMINO 4 CYANOPHENYLTHIO)BENZYLAMINE C 11; NORSERTRALINE; RADIOPHARMACEUTICAL AGENT; SEROTONIN; SEROTONIN TRANSPORTER; SERTRALINE; UNCLASSIFIED DRUG;

ADULT; ARTERY; ARTICLE; AUTOPSY; AUTORADIOGRAPHY; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; FEMALE; HUMAN; HUMAN EXPERIMENT; INFUSION; MALE; MEASUREMENT; NORMAL HUMAN; OUTCOME ASSESSMENT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PSYCHIATRIC TREATMENT; QUANTITATIVE ANALYSIS; SEROTONIN BRAIN LEVEL; STEADY STATE; UNSPECIFIED SIDE EFFECT; VOLUNTEER;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AUTORADIOGRAPHY; BENZYLAMINES; BRAIN; BRAIN MAPPING; CARBON ISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMIPRAMINE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; POSTMORTEM CHANGES; REFERENCE VALUES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; TIME FACTORS; TISSUE DISTRIBUTION; TRITIUM;

EID: 33645100049     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.08.010     Document Type: Article

References (50)

1. Abi-Dargham A., Simpson N., Kegeles L., Parsey R., Hwang D.R., Anjilvel S., et al. PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756. Synapse 32 (1999) 93-109
2. Arango V., Underwood M.D., Gubbi A.V., and Mann J.J. Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res 688 (1995) 121-133
3. Belanger M.J., Simpson N.R., Wang T., Van Heertum R.L., Mann J.J., and Parsey R.V. Biodistribution and radiation dosimetry of [(11)C]DASB in baboons. Nucl Med Biol 31 (2004) 1097-1102
4. Benmansour S., Cecchi M., Morilak D.A., Gerhardt G.A., Javors M.A., Gould G.G., et al. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. J Neurosci 19 (1999) 10494-10501
5. Blier P., and de Montigny C. Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders. Neuropsychopharmacology 21 (1999) 91S-98S
6. Bogetto F., Albert U., and Maina G. Sertraline treatment of obsessive-compulsive disorder. efficacy and tolerability of a rapid titration regimen. Eur Neuropsychopharmacol 12 (2002) 181-186
7. Carrasco J.L., Diaz-Marsa M., and Saiz-Ruiz J. Sertraline in the treatment of mixed anxiety and depression disorder. J Affect Disord 59 (2000) 67-69
8. Carson R.E. PET paramter estimation using llinear integration methods. bias and variability consideration. Quantification of brain function: tracer kinetics and image analysis in brain PET: proceedings of Brain PET '93 Akita: Quantification of Brain Function, Akita, Japan, 29-31 May (1993), Excerpta Medica, Amsterdam; New York 499-507
9. Duvernoy H. The human brain. Surface, three-dimensional sectional anatomy and MRI (1991), Sringer-Verlag Wien, New York
10. Fabre L.F., Abuzzahab F.S., Amin M., Claghorn J.L., Mendels J., Petrie W.M., et al. Sertraline safety and efficacy in major depression. a double-blind fixed-dose comparison with placebo. Biol Psychiatry 38 (1995) 592-602
11. First Sr. M.B., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders (1997), American Psychiatric Press, Washington D.C
12. Frankle W.G., Huang Y., Hwang D.R., Talbot P.S., Slifstein M., Van Heertum R., et al. Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans. J Nucl Med 45 (2004) 682-694
13. Ginovart N., Wilson A.A., Meyer J.H., Hussey D., and Houle S. Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter. modeling strategies. J Cereb Blood Flow Metab 21 (2001) 1342-1353
14. Houle S., Ginovart N., Hussey D., Meyer J.H., and Wilson A.A. Imaging the serotonin transporter with positron emission tomography. initial human studies with [11C]DAPP and [11C]DASB. Eur J Nucl Med 27 (2000) 1719-1722
15. Ichise M., Liow J.S., Lu J.Q., Takano A., Model K., Toyama H., et al. Linearized reference tissue parametric imaging methods. application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab 23 (2003) 1096-1112
16. Jenkinson M., and Smith S. A global optimisation method for robust affine registration of brain images. Med Image Anal 5 (2001) 143-156
17. Kates W.R., Abrams M.T., Kaufmann W.E., Breiter S.N., and Reiss A.L. Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiat Res Neuroimag 75 (1997) 31-48
18. Kent J.M., Coplan J.D., Lombardo I., Hwang D.R., Huang Y., Mawlawi O., et al. Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia. a positron emission tomography study with [(11)C]McN 5652. Psychopharmacology (Berl) 164 (2002) 341-348
19. Killiany R.J., Moss M.B., Nicholson T., Jolesz F., and Sandor T. An interactive procedure for extracting features of the brain from magnetic resonance images. The lobes. Human Brain Mapping 5 (1997) 355-363
20. Kish S.J., Furukawa Y., Chang L.J., Tong J., Ginovart N., Wilson A., et al. Regional distribution of serotonin transporter protein in postmortem human brain Is the cerebellum a SERT-free brain region?. Nucl Med Biol 32 (2005) 123-128
21. Kretzschmar M., Brust P., Zessin J., Cumming P., Bergmann R., and Johannsen B. Autoradiographic imaging of the serotonin transporter in the brain of rats and pigs using S-([18F]fluoromethyl)-(+)-McN5652. Eur Neuropsychopharmacol 13 (2003) 387-397
22. Kronig M.H., Apter J., Asnis G., Bystritsky A., Curtis G., Ferguson J., et al. Placebo-controlled, multicenter study of sertraline treatment for obsessive-compulsive disorder. J Clin Psychopharmacol 19 (1999) 172-176
23. Laruelle M., Abi-Dargham A., al-Tikriti M.S., Baldwin R.M., Zea-Ponce Y., Zoghbi S.S., et al. SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors in nonhuman primates: II. Equilibrium analysis of constant infusion experiments and correlation with in vitro parameters. J Cereb Blood Flow Metab 14 (1994) 453-465
24. Lemieux L., Hammers A., Mackinnon T., and Liu R.S. Automatic segmentation of the brain and intracranial cerebrospinal fluid in T1-weighted volume MRI scans of the head, and its application to serial cerebral and intracranial volumetry. Magn Reson Med 49 (2003) 872-884
25. Logan J., Fowler J.S., Volkow N.D., Wang G.J., Ding Y.S., and Alexoff D.L. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab 16 (1996) 834-840
26. Mawlawi O., Martinez D., Slifstein M., Broft A., Chatterjee R., Hwang D.R., et al. Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D(2) receptor parameter measurements in ventral striatum. J Cereb Blood Flow Metab 21 (2001) 1034-1057
27. Meyer J.H., Wilson A.A., Ginovart N., Goulding V., Hussey D., Hood K., et al. Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression. a [(11)C]DASB PET imaging study. Am J Psychiatry 158 (2001) 1843-1849
28. Meyer J.H., Wilson A.A., Sagrati S., Hussey D., Carella A., Potter W.Z., et al. Serotonin Transporter Occupancy of Five Selective Serotonin Reuptake Inhibitors at Different Doses. An [(11)C]DASB Positron Emission Tomography Study. Am J Psychiatry 161 (2004) 826-835
29. Mintun M.A., Raichle M.E., Kilbourn M.R., Wooten G.F., and Welch M.J. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 15 (1984) 217-227
30. Ogden R.T. On estimation of kinetic parameters in graphical analysis of PET imaging data. Statistics in Medicine 22 (2003) 3557-3568
31. Ogden R.T., Parsey R.V., and Mann J.J. Likelihood approach to parameter estimation in Logan graphical analaysis. Neuroimage 16 (2002) S73
32. Parsey RV, Hastings RS, Oquendo MA, Huang Y, Simpson N, Arcement J, et al (in press): [11C]McN5652 Binding to the Serotonin Transporter in Human Brain: Lower Binding During a Major Depressive Episode. Am J Psychiatry.
33. Parsey R.V., Kegeles L.S., Hwang D.R., Simpson N., Abi-Dargham A., Mawlawi O., et al. In vivo quantification of brain serotonin transporters in humans using [11C]McN 5652. J Nucl Med 41 (2000) 1465-1477
34. Parsey R.V., Ogden R.T., and Mann J.J. Determination of Volume of Distribution using Likelihood Estimation in Graphical Analysis. Elimination of Estimation Bias. J Cereb Blood Flow Metab 23 (2003) 1471-1478
35. Parsey R.V., Slifstein M., Hwang D.R., Abi-Dargham A., Simpson N., Mawlawi O., et al. Validation and reproducibility of measurement of 5-HT1A receptor parameters with [carbonyl-11C]WAY-100635 in humans. comparison of arterial and reference tisssue input functions. J Cereb Blood Flow Metab 20 (2000) 1111-1133
36. Preskorn S.H. Pharmacokinetics of antidepressants. why and how they are relevant to treatment. J Clin Psychiatry 54 Suppl:14-34; discussion (1993) 55-56
37. Preskorn S.H., and Lane R.M. Sertraline 50 mg daily. the optimal dose in the treatment of depression. Int Clin Psychopharmacol 10 (1995) 129-141
38. Ravindran A.V., Guelfi J.D., Lane R.M., and Cassano G.B. Treatment of dysthymia with sertraline. a double-blind, placebo-controlled trial in dysthymic patients without major depression. J Clin Psychiatry 61 (2000) 821-827
39. Sheikh J.I., Lauderdale S.A., and Cassidy E.L. Efficacy of sertraline for panic disorder in older adults. a preliminary open-label trial. Am J Geriatr Psychiatry 12 (2004) 230
40. Shelton R.C. The dual-action hypothesis. does pharmacology matter?. J Clin Psychiatry 65 Suppl 17 (2004) 5-10
41. Slifstein M., and Laruelle M. Effects of statistical noise on graphic analysis of PET neuroreceptor studies. J Nucl Med 41 (2000) 2083-2088
42. Suckow R.F., Zhang M.F., and Cooper T.B. Sensitive and selective liquid-chromatographic assay of fluoxetine and norfluoxetine in plasma with fluorescence detection after precolumn derivatization. Clin Chem 38 (1992) 1756-1761
43. Suhara T., Takano A., Sudo Y., Ichimiya T., Inoue M., Yasuno F., et al. High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography. Arch Gen Psychiatry 60 (2003) 386-391
44. Szabo Z., McCann U.D., Wilson A.A., Scheffel U., Owonikoko T., Mathews W.B., et al. Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various experimental conditions. J Nucl Med 43 (2002) 678-692
45. Talairach J., and Tournoux P. Co-planar stereotactic atlas of the human brain. Three-dimensional proportional system: an approach of cerebral imaging (1988), Theime Medical Publisher, New York
46. Tatsumi M., Groshan K., Blakely R.D., and Richelson E. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 340 (1997) 249-258
47. Watson C.C., Newport D., and Casey M.E. A single scatter simulation technique for scatter correction in 3D PET, Fully three-dimensional image reconstruction in radiology and nuclear medicine (1995), Aix-les-bains, France pp 215-219
48. Wilkinson G.R. Chapter 1: Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination. In: Hardman J.G., Limbird L.E., and Gilman A.G. (Eds). The Pharmacological Basis of Therapeutics. 10 ed. (2001) McGraw-Hill, pp 23
49. Wilson A.A., Ginovart N., Hussey D., Meyer J., and Houle S. In vitro and in vivo characterisation of [11C]-DASB. a probe for in vivo measurements of the serotonin transporter by positron emission tomography. Nucl Med Biol 29 (2002) 509-515
50. Wilson A.A., Ginovart N., Schmidt M., Meyer J.H., Threlkeld P.G., and Houle S. Novel radiotracers for imaging the serotonin transporter by positron emission tomography. synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines. J Med Chem 43 (2000) 3103-3110