Fish somatostatin sst3 receptor: Comparison of radioligand and GTPγS binding, adenylate cyclase and phospholipase C activities reveals different agonist-dependent pharmacological signatures

Autonomic and Autacoid Pharmacology

Volumn 25, Issue 1, 2005, Pages 1-16

  Siehler, S ^a   Nunn, C ^a   Zupanc, G K H ^b,d   Hoyer, D ^a,c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d JACOBS UNIVERSITY BREMEN   (Germany)

Author keywords

Adenylate cyclase; Agonist dependent receptor trafficking; CCL39 Chinese hamster lung fibroblast cells; Fish somatostatin receptor 3; Guanosine 5 O (3 thio) triphosphate; Guanylylimidodiphosphate; Inositol phosphate; Somatostatin

Indexed keywords

ADENYLATE CYCLASE; CGP 23996; CORTISTATIN 14 [10 TYROSINE]; DEXTRO PHENYLALANYLPHENYLALANYLTYROSYL DEXTRO TRYPTOPHYLLYSYLVALYLPHENYLALANYL DEXTRO [3 (2 NAPHTHYL)ALANINAMIDE]; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE DERIVATIVE; GUANYLYLIMIDODIPHOSPHATE; IODINE 125; OCTREOTIDE[3 TYROSINE]; PERTUSSIS TOXIN; PHOSPHOLIPASE C; RADIOLIGAND; RECOMBINANT RECEPTOR; SOMATOSTATIN 28; SOMATOSTATIN 28 [8 LEUCINE 22 DEXTRO TRYPTOPHAN 25 TYROSINE]; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR 2; SOMATOSTATIN RECEPTOR 3; SOMATOSTATIN RECEPTOR 5; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; DRUG DERIVATIVE; INOSITOL PHOSPHATE; RADIOACTIVE IODINE; SOMATOSTATIN; SOMATOSTATIN RECEPTOR; SULFUR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FISH; LIGAND BINDING; NONHUMAN; PROTEIN FAMILY; RECEPTOR DENSITY; RECEPTOR INTRINSIC ACTIVITY; SECOND MESSENGER; ANIMAL; BINDING SITE; CELL LINE; CRICETULUS; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; GENETICS; HAMSTER; HUMAN; LUNG; METABOLISM; METHODOLOGY; PATHOLOGY; PHYSIOLOGY; RADIOASSAY;

ADENYLATE CYCLASE; ANIMALS; BINDING SITES; CELL LINE; CRICETINAE; CRICETULUS; FIBROBLASTS; FISHES; FORSKOLIN; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANYLYL IMIDODIPHOSPHATE; HUMANS; INOSITOL PHOSPHATES; IODINE RADIOISOTOPES; LUNG; PHOSPHOLIPASE C; RADIOLIGAND ASSAY; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; SULFUR ISOTOPES;

EID: 12944249387     PISSN: 14748665     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1474-8673.2004.00325.x     Document Type: Article

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