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Volumn 105, Issue 5, 2008, Pages 1970-1978

Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degeneration

Author keywords

Lactacystin; Neuroprotection; Neurorestoration; Rasagiline; Selegiline; Ubiquitin proteasome system

Indexed keywords

LACTACYSTIN; PROTEASOME INHIBITOR; RASAGILINE; SELEGILINE;

EID: 43549107707     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05330.x     Document Type: Article
Times cited : (55)

References (46)
  • 1
    • 0036677312 scopus 로고    scopus 로고
    • Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan
    • Akao Y., Maruyama W., Shimizu S., Yi H., Nakagawa Y., Shamoto-Nagai M., Youdim M. B., Tsujimoto Y. Naoi M. (2002) Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan. J. Neurochem. 82 (4 913 923.
    • (2002) J. Neurochem. , vol.82 , Issue.4 , pp. 913-923
    • Akao, Y.1    Maruyama, W.2    Shimizu, S.3    Yi, H.4    Nakagawa, Y.5    Shamoto-Nagai, M.6    Youdim, M.B.7    Tsujimoto, Y.8    Naoi, M.9
  • 2
    • 1542317394 scopus 로고    scopus 로고
    • Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline
    • Am O. B., Amit T. Youdim M. B. (2004) Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline. Neurosci. Lett. 355 (3 169 172.
    • (2004) Neurosci. Lett. , vol.355 , Issue.3 , pp. 169-172
    • Am, O.B.1    Amit, T.2    Youdim, M.B.3
  • 3
    • 34848906324 scopus 로고    scopus 로고
    • Aminoindan and hydroxyaminoindan, metabolites of rasagiline and ladostigil, respectively, exert neuroprotective properties in vitro
    • Bar-Am O., Amit T. Youdim M. B. (2007). Aminoindan and hydroxyaminoindan, metabolites of rasagiline and ladostigil, respectively, exert neuroprotective properties in vitro. J. Neurochem. 103, 500 508.
    • (2007) J. Neurochem. , vol.103 , pp. 500-508
    • Bar-Am, O.1    Amit, T.2    Youdim, M.B.3
  • 5
    • 24644441649 scopus 로고    scopus 로고
    • Neuroprotection by rasagiline: A new therapeutic approach to Parkinson's disease?
    • Blandini F. (2005) Neuroprotection by rasagiline: a new therapeutic approach to Parkinson's disease? CNS Drug Rev. 11 (2 183 194.
    • (2005) CNS Drug Rev. , vol.11 , Issue.2 , pp. 183-194
    • Blandini, F.1
  • 6
    • 23044514579 scopus 로고    scopus 로고
    • Clinical pharmacology of rasagiline: A novel, second-generation propargylamine for the treatment of Parkinson disease
    • Chen J. J. Swope D. M. (2006) Clinical pharmacology of rasagiline: a novel, second-generation propargylamine for the treatment of Parkinson disease. J. Clin. Pharmacol. 45 (8 878 894.
    • (2006) J. Clin. Pharmacol. , vol.45 , Issue.8 , pp. 878-894
    • Chen, J.J.1    Swope, D.M.2
  • 7
    • 0034065822 scopus 로고    scopus 로고
    • Ubiquitin-mediated proteolysis: Biological regulation via destruction
    • Ciechanover A., Orian A. Schwartz A. L. (2000) Ubiquitin-mediated proteolysis: biological regulation via destruction. Bioessays 22 (5 442 451.
    • (2000) Bioessays , vol.22 , Issue.5 , pp. 442-451
    • Ciechanover, A.1    Orian, A.2    Schwartz, A.L.3
  • 8
    • 33644652951 scopus 로고    scopus 로고
    • Proteasome regulation of oxidative stress in aging and age-related diseases of the CNS
    • Ding Q., Dimayuga E. Keller J. N. (2006) Proteasome regulation of oxidative stress in aging and age-related diseases of the CNS. Antioxid. Redox Signal. 8 (1-2 163 172.
    • (2006) Antioxid. Redox Signal. , vol.8 , Issue.12 , pp. 163-172
    • Ding, Q.1    Dimayuga, E.2    Keller, J.N.3
  • 10
    • 0141753018 scopus 로고    scopus 로고
    • Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition
    • Fornai F., Lenzi P., Gesi M. et al. (2003) Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition. J. Neurosci. 23 (26 8955 8966.
    • (2003) J. Neurosci. , vol.23 , Issue.26 , pp. 8955-8966
    • Fornai, F.1    Lenzi, P.2    Gesi, M.3
  • 11
    • 10444238568 scopus 로고    scopus 로고
    • Similarities between methamphetamine toxicity and proteasome inhibition
    • Fornai F., Lenzi P., Gesi M. et al. (2004) Similarities between methamphetamine toxicity and proteasome inhibition. Ann. NY Acad. Sci. 1025, 162 170.
    • (2004) Ann. NY Acad. Sci. , vol.1025 , pp. 162-170
    • Fornai, F.1    Lenzi, P.2    Gesi, M.3
  • 13
    • 0037321610 scopus 로고    scopus 로고
    • Attenuation of methamphetamine induced dopaminergic neurotoxicity by flupirtine: Microdialysis study on dopamine release and free radical generation
    • Gassen M., Lamensdorf I., Armony T., Finberg J. P. Youdim M. B. (2003) Attenuation of methamphetamine induced dopaminergic neurotoxicity by flupirtine: microdialysis study on dopamine release and free radical generation. J. Neural. Transm. 110 (2 171 182.
    • (2003) J. Neural. Transm. , vol.110 , Issue.2 , pp. 171-182
    • Gassen, M.1    Lamensdorf, I.2    Armony, T.3    Finberg, J.P.4    Youdim, M.B.5
  • 14
    • 0035171590 scopus 로고    scopus 로고
    • Novel aspects of dopamine oxidative metabolism (confounding outcomes take place of certainties)
    • Gesi M., Santinami A., Ruffoli R., Conti G. Fornai F. (2001) Novel aspects of dopamine oxidative metabolism (confounding outcomes take place of certainties). Pharmacol. Toxicol. 89 (5 217 224.
    • (2001) Pharmacol. Toxicol. , vol.89 , Issue.5 , pp. 217-224
    • Gesi, M.1    Santinami, A.2    Ruffoli, R.3    Conti, G.4    Fornai, F.5
  • 15
    • 0033794522 scopus 로고    scopus 로고
    • Stereology, morphometry, and mapping: The whole is greater than the sum of its parts
    • Glaser J. R. Glaser E. M. (2000) Stereology, morphometry, and mapping: the whole is greater than the sum of its parts. J. Chem. Neuroanat. 20, 115 126.
    • (2000) J. Chem. Neuroanat. , vol.20 , pp. 115-126
    • Glaser, J.R.1    Glaser, E.M.2
  • 16
    • 19944428747 scopus 로고    scopus 로고
    • Gene expression profiling of parkinsonian substantia nigra pars compacta; Alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes
    • Grunblatt E., Mandel S., Jacob-Hirsch J. et al. (2004) Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes. J. Neural. Transm. 111 (12 1543 1573.
    • (2004) J. Neural. Transm. , vol.111 , Issue.12 , pp. 1543-1573
    • Grunblatt, E.1    Mandel, S.2    Jacob-Hirsch, J.3
  • 19
    • 0035894104 scopus 로고    scopus 로고
    • Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome
    • Lee M., Hyun D. H., Marshall K. A., Ellerby L. M., Bredesen D. E., Jenner P. Halliwell B. (2001) Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome. Free Radic. Biol. Med. 31 (12 1550 1559.
    • (2001) Free Radic. Biol. Med. , vol.31 , Issue.12 , pp. 1550-1559
    • Lee, M.1    Hyun, D.H.2    Marshall, K.A.3    Ellerby, L.M.4    Bredesen, D.E.5    Jenner, P.6    Halliwell, B.7
  • 20
    • 33344461775 scopus 로고    scopus 로고
    • Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease
    • McNaught K. S. Olanow C. W. (2006) Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease. Neurobiol. Aging 27 (4 530 545.
    • (2006) Neurobiol. Aging , vol.27 , Issue.4 , pp. 530-545
    • McNaught, K.S.1    Olanow, C.W.2
  • 21
    • 3042794162 scopus 로고    scopus 로고
    • Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
    • McNaught K. S., Perl D. P., Brownell A. L. Olanow C. W. (2003) Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann. Neurol. 56 (1 149 162.
    • (2003) Ann. Neurol. , vol.56 , Issue.1 , pp. 149-162
    • McNaught, K.S.1    Perl, D.P.2    Brownell, A.L.3    Olanow, C.W.4
  • 22
    • 0041920820 scopus 로고    scopus 로고
    • D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine-induced dopaminergic neurotoxicity
    • Muralikrishnan D., Samantaray S. Mohanakumar K. P. (2003) D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced dopaminergic neurotoxicity. Synapse 50 (1 7 13.
    • (2003) Synapse , vol.50 , Issue.1 , pp. 7-13
    • Muralikrishnan, D.1    Samantaray, S.2    Mohanakumar, K.P.3
  • 23
    • 34248524384 scopus 로고    scopus 로고
    • Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: Possible implications of glial cells
    • Nagatsu T. Sawada M. (2006) Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: possible implications of glial cells. J. Neural Transm. Suppl. 71, 53 65.
    • (2006) J. Neural Transm. Suppl. , vol.71 , pp. 53-65
    • Nagatsu, T.1    Sawada, M.2
  • 24
    • 33845994064 scopus 로고    scopus 로고
    • P53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition
    • Nair V. D., McNaught K. S., Gonzalez-Maeso J., Sealfon S. C. Olanow C. W. (2006) p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. J. Biol. Chem. 281 (51 39550 39560.
    • (2006) J. Biol. Chem. , vol.281 , Issue.51 , pp. 39550-39560
    • Nair, V.D.1    McNaught, K.S.2    Gonzalez-Maeso, J.3    Sealfon, S.C.4    Olanow, C.W.5
  • 25
    • 33744980931 scopus 로고    scopus 로고
    • Rationale for considering that propargylamines might be neuroprotective in Parkinson's disease
    • Olanow C. W. (2006) Rationale for considering that propargylamines might be neuroprotective in Parkinson's disease. Neurology 66 (10 Suppl. 4 S69 S79.
    • (2006) Neurology , vol.66 , Issue.104
    • Olanow, C.W.1
  • 26
    • 33646686620 scopus 로고    scopus 로고
    • Selegiline slows the progression of the symptoms of Parkinson disease
    • Swedish Parkinson Study Group (
    • Palhagen S., Heinonen E., Hagglund J., Kaugesaar T., Maki-Ikola O., Palm R. Swedish Parkinson Study Group (2006) Selegiline slows the progression of the symptoms of Parkinson disease. Neurology 66 (8 1200 1206.
    • (2006) Neurology , vol.66 , Issue.8 , pp. 1200-1206
    • Palhagen, S.1    Heinonen, E.2    Hagglund, J.3    Kaugesaar, T.4    Maki-Ikola, O.5    Palm, R.6
  • 27
    • 2342655732 scopus 로고    scopus 로고
    • A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease
    • Parkinson Study Group (
    • Parkinson Study Group (2004) A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease. Arch. Neurol. 61 (4 561 566.
    • (2004) Arch. Neurol. , vol.61 , Issue.4 , pp. 561-566
  • 28
    • 20144381356 scopus 로고    scopus 로고
    • Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition
    • Rideout H. J., Lang-Rollin I. C., Savalle M. Stefanis L. (2005) Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition. J. Neurochem. 93 (5 1304 1313.
    • (2005) J. Neurochem. , vol.93 , Issue.5 , pp. 1304-1313
    • Rideout, H.J.1    Lang-Rollin, I.C.2    Savalle, M.3    Stefanis, L.4
  • 29
    • 33751078859 scopus 로고    scopus 로고
    • Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism
    • Sagi Y., Mandel S., Amit T. Youdim M. B. (2007) Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism. Neurobiol. Dis. 25 (1 35 44.
    • (2007) Neurobiol. Dis. , vol.25 , Issue.1 , pp. 35-44
    • Sagi, Y.1    Mandel, S.2    Amit, T.3    Youdim, M.B.4
  • 30
    • 0031711714 scopus 로고    scopus 로고
    • DATATOP: A decade of neuroprotective inquiry. Parkinson Study Group. Deprenyl and tocopherol antioxidative therapy of Parkinsonism
    • Shoulson I. (1998) DATATOP: a decade of neuroprotective inquiry. Parkinson Study Group. Deprenyl and tocopherol antioxidative therapy of Parkinsonism. Ann. Neurol. 44 (3 Suppl. 1 S160 S166.
    • (1998) Ann. Neurol. , vol.44 , Issue.31
    • Shoulson, I.1
  • 31
    • 0037501731 scopus 로고    scopus 로고
    • Update on Parkinson disease
    • Siderowf A. Stern M. (2003) Update on Parkinson disease. Ann. Intern. Med. 138 (8 651 658.
    • (2003) Ann. Intern. Med. , vol.138 , Issue.8 , pp. 651-658
    • Siderowf, A.1    Stern, M.2
  • 32
    • 0347635418 scopus 로고    scopus 로고
    • Neuroprotection by monoamine oxidase B inhibitors: A therapeutic strategy for Parkinson's disease?
    • Tabakman R., Lecht S. Lazarovici P. (2004) Neuroprotection by monoamine oxidase B inhibitors: a therapeutic strategy for Parkinson's disease? Bioessays 26 (1 80 90.
    • (2004) Bioessays , vol.26 , Issue.1 , pp. 80-90
    • Tabakman, R.1    Lecht, S.2    Lazarovici, P.3
  • 33
    • 0036229947 scopus 로고    scopus 로고
    • Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells
    • Tatton W. G., Chalmers-Redman R. M., Ju W. J., Mammen M., Carlile G. W., Pong A. W. Tatton N. A. (2002) Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells. J. Pharmacol. Exp. Ther. 301 (2 753 764.
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , Issue.2 , pp. 753-764
    • Tatton, W.G.1    Chalmers-Redman, R.M.2    Ju, W.J.3    Mammen, M.4    Carlile, G.W.5    Pong, A.W.6    Tatton, N.A.7
  • 35
    • 33750358311 scopus 로고    scopus 로고
    • Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety
    • Weinreb O., Amit T., Bar-Am O., Sagi Y., Mandel S. Youdim M. B. (2006) Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety. J. Neural Transm. Suppl. 70, 457 465.
    • (2006) J. Neural Transm. Suppl. , vol.70 , pp. 457-465
    • Weinreb, O.1    Amit, T.2    Bar-Am, O.3    Sagi, Y.4    Mandel, S.5    Youdim, M.B.6
  • 36
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • West M. J., Slomianka L. Gundersen H. J. (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 231 (4 482 497.
    • (1991) Anat. Rec. , vol.231 , Issue.4 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.3
  • 37
    • 33745676834 scopus 로고    scopus 로고
    • Amphetamine-induced locomotor activity is reduced in mice following MPTP treatment but not following selegiline/MPTP treatment
    • West B. D., Shughrue P. J., Vanko A. E., Ransom R. W. Kinney G. G. (2006) Amphetamine-induced locomotor activity is reduced in mice following MPTP treatment but not following selegiline/MPTP treatment. Pharmacol. Biochem. Behav. 84 (1 158 161.
    • (2006) Pharmacol. Biochem. Behav. , vol.84 , Issue.1 , pp. 158-161
    • West, B.D.1    Shughrue, P.J.2    Vanko, A.E.3    Ransom, R.W.4    Kinney, G.G.5
  • 38
    • 30444437749 scopus 로고    scopus 로고
    • Monoamine oxidase: Isoforms and inhibitors in Parkinson's disease and depressive illness
    • Youdim M. B. Bakhle Y. S. (2006) Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness. Br. J. Pharmacol. 147 (Suppl. 1 S287 S296.
    • (2006) Br. J. Pharmacol. , vol.147 , Issue.1
    • Youdim, M.B.1    Bakhle, Y.S.2
  • 39
    • 0036162584 scopus 로고    scopus 로고
    • Rat striatal monoamine oxidase-B inhibition by L-deprenyl and rasagiline: Its relationship to 2-phenylethylamine-induced stereotypy and Parkinson's disease
    • Youdim M. B. Tipton K. F. (2002) Rat striatal monoamine oxidase-B inhibition by L-deprenyl and rasagiline: its relationship to 2-phenylethylamine-induced stereotypy and Parkinson's disease. Parkinsonism Relat Disord. 8 (4 247 253.
    • (2002) Parkinsonism Relat Disord. , vol.8 , Issue.4 , pp. 247-253
    • Youdim, M.B.1    Tipton, K.F.2
  • 40
    • 0034941767 scopus 로고    scopus 로고
    • The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo
    • Youdim M. B., Wadia A., Tatton W. Weinstock M. (2001) The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo. Ann. NY Acad. Sci. 939, 450 458.
    • (2001) Ann. NY Acad. Sci. , vol.939 , pp. 450-458
    • Youdim, M.B.1    Wadia, A.2    Tatton, W.3    Weinstock, M.4
  • 41
    • 1642318304 scopus 로고    scopus 로고
    • Neuroprotective action of rasagiline is dependent of rasagiline is dependent on activation of Bcl-2, PKC and proteasome complex and inhibition of mitochondrial permeability transition (PT)
    • Youdim M. B., Maruyama W. Naoi M. (2002) Neuroprotective action of rasagiline is dependent of rasagiline is dependent on activation of Bcl-2, PKC and proteasome complex and inhibition of mitochondrial permeability transition (PT). Neural Plast. 9 (2 125 126.
    • (2002) Neural Plast. , vol.9 , Issue.2 , pp. 125-126
    • Youdim, M.B.1    Maruyama, W.2    Naoi, M.3
  • 42
    • 0642345197 scopus 로고    scopus 로고
    • The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline
    • Youdim M. B., Amit T., Falach-Yogev M., Am O. B., Maruyama W. Naoi M. (2003) The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline. Biochem. Pharmacol. 66 (8 1635 1641.
    • (2003) Biochem. Pharmacol. , vol.66 , Issue.8 , pp. 1635-1641
    • Youdim, M.B.1    Amit, T.2    Falach-Yogev, M.3    Am, O.B.4    Maruyama, W.5    Naoi, M.6
  • 43
    • 23144441835 scopus 로고    scopus 로고
    • Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline
    • Youdim M. B., Maruyama W. Naoi M. (2005) Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline. Drugs Today (Barc.) 41, 369 391.
    • (2005) Drugs Today (Barc.) , vol.41 , pp. 369-391
    • Youdim, M.B.1    Maruyama, W.2    Naoi, M.3
  • 45
    • 20544465100 scopus 로고    scopus 로고
    • Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration
    • Zhang X., Xie W., Qu S., Pan T., Wang X. Le W. (2005) Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration. Biochem. Biophys. Res. Commun. 333 (2 544 549.
    • (2005) Biochem. Biophys. Res. Commun. , vol.333 , Issue.2 , pp. 544-549
    • Zhang, X.1    Xie, W.2    Qu, S.3    Pan, T.4    Wang, X.5    Le, W.6
  • 46
    • 36849044036 scopus 로고    scopus 로고
    • Novel brain permeable iron chelators prevent lactacystin induced ubiquitin-proteasome inhibition and degeneration of nigrostriatal dopamine neurons
    • Zhu W., Wenjie Xie, Pan T., Xu P., Fridkin M., Zheng H., Jankovic J., Youdim M. B. Le W. (2007) Novel brain permeable iron chelators prevent lactacystin induced ubiquitin-proteasome inhibition and degeneration of nigrostriatal dopamine neurons. FESAB J. 21 (14 3835 3844.
    • (2007) FESAB J. , vol.21 , Issue.14 , pp. 3835-3844
    • Zhu, Xie.1    Pan, T.2    Xu, P.3    Fridkin, M.4    Zheng, H.5    Jankovic, J.6    Youdim, M.B.7    Le, W.8


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